Results 11 to 20 of about 115,653 (351)

Virus Binding and Internalization Assay for Adeno-associated Virus

Bio-Protocol, 2017
The binding and internalization of adeno-associated virus (AAV) is an important determinant of viral infectivity and tropism. The ability to dissect these two tightly connected cellular processes would allow better understanding and provide insight on ...
Garrett Berry, Victor Tse
doaj   +4 more sources

Protein Carrier Adeno-Associated Virus. [PDF]

ACS Nano
Adeno-associated virus (AAV) has emerged as a leading platform for gene therapy, enabling the delivery of therapeutic DNA to target cells. However, the potential of AAV to deliver protein payloads has been unexplored. In this study, we engineered a protein carrier AAV (pcAAV) to package and deliver proteins by inserting binding domains on the interior ...
Hoffmann MD, Sorensen RJ, Extross A, He Y, Schmidt D.   +4 more
europepmc   +3 more sources

Infectious Entry Pathway of Adeno-Associated Virus and Adeno-Associated Virus Vectors [PDF]

Journal of Virology, 2000
ABSTRACT We have investigated the infectious entry pathway of adeno-associated virus (AAV) and recombinant AAV vectors by assessing AAV-mediated gene transfer and by covalently conjugating fluorophores to AAV and monitoring entry by fluorescence microscopy.
J S, Bartlett, R, Wilcher, R J, Samulski
openaire   +2 more sources

Surface immobilization of hexa-histidine-tagged adeno-associated viral vectors for localized gene delivery. [PDF]

, 2010
Adeno-associated viral (AAV) vectors, which are undergoing broad exploration in clinical trials, have significant promise for therapeutic gene delivery because of their safety and delivery efficiency.
Bethi, SR, Gujraty, K, Jang, J-H, Kane, RS, Koerber, JT, Schaffer, DV   +5 more
core   +5 more sources

Transduction of Salivary Gland Acinar Cells with a Novel AAV Vector 44.9

Molecular Therapy: Methods & Clinical Development, 2020
The loss of salivary gland function caused by radiation therapy of the head and neck or autoimmune disease such as Sjögren’s syndrome is a serious condition that affects a patient’s quality of life. Due to the combined exocrine and endocrine functions of
Giovanni Di Pasquale, Paola Perez Riveros, Muhibullah Tora, Tayyab Sheikh, Aran Son, Leyla Teos, Brigitte Grewe, William D. Swaim, Sandra Afione, Changyu Zheng, Shyh-Ing Jang, Akiko Shitara, Ilias Alevizos, Roberto Weigert, John A. Chiorini   +14 more
doaj   +1 more source

Clinical and laboratory evaluation of sicca complaints: distinctive aspects of primary, secondary and non-Sjogren syndrome

Advances in Rheumatology, 2022
Background Sjögren Syndrome (SS) is a systemic autoimmune disease with a wide spectrum of manifestations that can lead to misdiagnosis. This study describes and compares demographic, clinical, serological, and histopathological data from subjects with SS
Fabíola Reis de Oliveira, Ana Carolina F. Motta, Carolina Maria Módulo, Denny Marcos Garcia, John A. Chiorini, Paulo Louzada-Junior, Eduardo Melani Rocha   +6 more
doaj   +1 more source

Impact of multiplicity of infection and baculovirus co-infection ratio on recombinant adeno-associated virus vector production in insect cells. [PDF]

Front Bioeng Biotechnol
Schrama M, de Jong LA, Kint S, Puri P, Hoeksema F, Pijlman GP, van Oers MM, Wijffels RH, Martens DE.   +8 more
europepmc   +3 more sources

The landscape of viral associations in human cancers [PDF]

, 2020
Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential ...
Alawi, Malik, Borozan, Ivan, Brewer, Daniel S, Cooper, Colin S, Desai, Nikita, Eils, Roland, Ferretti, Vincent, Grundhoff, Adam, Iskar, Murat, Lichter, Peter, Moch, Holger, PCAWG Consortium, PCAWG Pathogens, Sültmann, Holger, Zapatka, Marc   +14 more
core   +3 more sources

Progress in the use of adeno-associated viral vectors for gene therapy [PDF]

, 2004
The development of safe and efficient gene transfer vectors is crucial for the success of gene therapy trials. A viral vector system promising to meet these requirements is based on the apathogenic adeno-associated virus (AAV-2), a member of the ...
Braun-Falco, M., Buning, H., Hallek, M.
core   +1 more source

Adeno-associated Virus DNA Replication [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 1979
ABSTRACT. A model for the replication of adeno-associated virus (AAV) DNA is presented. The AAV genome is a linear single-stranded DNA molecule which contains a 145 nucleotide inverted terminal repetition of which the first 125 nucleotides form a palindromic sequence.
K I, Berns, W W, Hauswirth, K H, Fife, E, Lusby   +3 more
openaire   +2 more sources