Suppressing microtubule detyrosination augments adeno-associated virus 2 endosomal escape and gene delivery. [PDF]
J Cell SciTripathi S +5 more
europepmc +1 more source
The Amino Acid Linker between the Endonuclease and Helicase Domains of Adeno-Associated Virus Type 5 Rep Plays a Critical Role in DNA-Dependent Oligomerization [PDF]
, 2011 Jenna E. Maggin +4 more
openalex +1 more source
AAV Assembled Capsids Are Produced in Cells Blocked From Cell Cycle Progression
Biotechnology and Bioengineering, EarlyView.ABSTRACT Adeno‐associated virus (AAV) is a promising delivery system for gene therapy. However, current manufacturing of AAV suffers from very low yields compared to other biotherapeutics. The AAV dose per patient ranges between 1011and 1015 viral genomes (vg), requiring an average of 10 to 30 L production/dose.
Alaka Mullick +8 more
wiley +1 more source
Heterogeneity in an adeno-associated virus transfection-based production process limits the production efficiency. [PDF]
Sci RepLadd B +5 more
europepmc +1 more source
Generation of light-producing somatic-transgenic mice using adeno-associated virus vectors [PDF]
, 2020 al., et +2 more
core +1 more source
Optimization of CEST MRI Reporter Protein Design Using Cation‐Pi Networks
Chemistry – A European Journal, EarlyView.A novel engineering approach can produce reporter proteins for cell and viral therapy tracking with unique magnetic resonance imaging (MRI) signatures, detectable with chemical exchange saturation transfer (CEST). We discover how cation‐π interactions between amino acid groups can help us fine‐tune magnetic resonance properties for noninvasive ...
David E. Korenchan +8 more
wiley +1 more source
Tropism and Retinal Transduction Efficiency of Adeno-Associated Virus Serotypes in Mice. [PDF]
Invest Ophthalmol Vis SciWu W, McRae J, Brown A, Agbaga MP.
europepmc +1 more source
159. Recombinant Adeno-Associated Virus Vectors Effectively Immunize Rabbits Via Intramuscular and Intranasal Routes [PDF]
, 2007 openalex +1 more source