Results 191 to 200 of about 116,785 (352)

Producing high-quantity and high-quality recombinant adeno-associated virus by low-cis triple transfection

Hao Liu, Yue Zhang, Mitchell Yip, Lingzhi Ren, Jialing Liang, X. Chen, Nan Liu, Ailing Du, Jiaming Wang, Hao Chang, Hyejin Oh, Chen Zhou, Ruxiao Xing, Mengyao Xu, Peiyi Guo, Dominic J. Gessler, Jun Xie, Phillip W.L. Tai, Guangping Gao, Dan Wang   +19 more
openalex   +1 more source

Adeno-Associated Virus-Based Gene Therapy for Lafora Disease in <i>Epm2b</i>-Deficient Mice. [PDF]

Int J Mol Sci
Zafra-Puerta L, Iglesias-Cabeza N, Sanz P, García-Gimeno MA, Sánchez-Martín G, Sánchez MP, Serratosa JM.   +6 more
europepmc   +1 more source

Suppressing microtubule detyrosination augments adeno-associated virus 2 endosomal escape and gene delivery. [PDF]

J Cell Sci
Tripathi S, Huda S, Kar J, Chandra D, Jayandharan GR, Mohan N.   +5 more
europepmc   +1 more source

An adeno-associated virus vector.

Uirusu, 1987
openaire   +3 more sources

Intravenous Adeno-Associated Virus Serotype 8 Encoding Urocortin-2 Provides Sustained Augmentation of Left Ventricular Function in Mice

, 2013
Mei Hua Gao, Ning Lai, Atsushi Miyanohara, Jan M. Schilling, Jorge Suárez, Tong Tang, Tracy Guo, Ruoying Tang, Jay Parikh, Dimosthenis Giamouridis, Wolfgang Dillmann, Hemal H. Patel, David M. Roth, Nancy D. Dalton, H. Kirk Hammond   +14 more
openalex   +1 more source

Adaptive Machine Learning Framework for Optimizing the Affinity Purification of Adeno‐Associated Viral Vectors

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Adeno‐associated viral (AAV) vectors for gene therapy are becoming integral to modern medicine, providing therapeutic options for diseases once deemed incurable. Currently, viral vector purification is a critical bottleneck in the gene therapy industry, impacting product efficacy and safety as well as accessibility and cost to patients ...
Kelvin P. Idanwekhai, Shriarjun Shastry, Morgan R. Hurst, Arianna Minzoni, Eduardo Barbieri, Luke Remmler, Eugene N. Muratov, Michael A. Daniele, Stefano Menegatti, Alexander Tropsha   +9 more
wiley   +1 more source

Heterogeneity in an adeno-associated virus transfection-based production process limits the production efficiency. [PDF]

Sci Rep
Ladd B, Tunmats S, Gräslund T, Daramola O, Rockberg J, Chotteau V.   +5 more
europepmc   +1 more source

A case study showing the role of hydrophobicity variants and other enriched mAb proteoforms on filterability through a virus filter with productivity improvement measures

Biotechnology Progress, EarlyView.
Abstract A rapid assessment of manufacturability for drug candidates is crucial for advancing a prospective biotherapeutic from a candidate to a bulk drug substance. A lot‐to‐lot approach to manufacturability is adopted where each biologic batch is assessed for manufacturability as a bulk, unfractionated pool.
Solomon Isu, Derek Silva, Melissa Holstein, Angela Lewandowski, Kristina Cunningham, Adam Sokolnicki, Bala Raghunath   +6 more
wiley   +1 more source

TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia

CNS Neuroscience &Therapeutics, EarlyView., 2023
Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi, Decheng Ren, Fan Yuan, Zhou Zhang, Daizhan Zhou, Xin Yi, Lei Ji, Keyi Li, Fengping Yang, Xi Wu, Xingwang Li, Yifeng Xu, Yun Liu, Peng Wang, Changqun Cai, Chuanxin Liu, Qian Ma, Lin He, Yi Shi, Guang He   +19 more
wiley   +1 more source

Insights into Adeno-Associated Virus Capsid Charge Heterogeneity. [PDF]

Anal Chem
Wu J, Draper BE, Jarrold MF, Heger CD.
europepmc   +1 more source