Results 251 to 260 of about 396,665 (375)

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Development and Characterization of Adeno-Associated Virus-Loaded Coaxial Electrospun Scaffolds for Potential Viral Vector Delivery. [PDF]

Polymers (Basel)
Zhang H, Zhou B, Dong W, Song Y, Hu Q, Zhang H, Yu M, Zhu G, Sun Y, Feng J.   +9 more
europepmc   +1 more source

Role for highly regulated rep gene expression in adeno-associated virus vector production

, 1997
Jian Li, R J Samulski, Xiangwei Xiao
openalex   +1 more source

Single‐component cationic polyethylenimine thermogel for sustained and localized gene delivery to combat multi‐drug resistant cancer

BMEMat, EarlyView.
A cationic thermogelling copolymer employing branched PEI‐25 kDa as the sole hydrophilic segment can be facilely complexed with plasmid by physical mixing in the sol phase. Spontaneous gelation is achieved via self‐assembly after injection due to physiological temperature. Sustained and localized release of plasmid from the cationic PEI‐thermogel leads
Qianyu Lin, Minting Liu, Lingjie Ke, Nicholas Wei Xun Ong, Joey Hui Min Wong, Cally Owh, Valerie Ow, Belynn Sim, Yi Jian Boo, Jason Y. C. Lim, Yunlong Wu, Xian Jun Loh   +11 more
wiley   +1 more source

A synthetic platform for developing recombinant adeno-associated virus type 8 producer cell lines. [PDF]

Biotechnol Prog
Lin YC, Kuo HJ, Lu M, Mahl T, Aslanidi G, Hu WS.   +5 more
europepmc   +1 more source

Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence, and readministration

, 1997
C. Halbert, T. A. Standaert, Moira L. Aitken, Ian E. Alexander, David W. Russell, A. Dusty Miller   +5 more
openalex   +1 more source

Iterative hybrid model based optimization of rAAV production

Biotechnology Progress, EarlyView.
Abstract Changes in serotype or genetic payload of recombinant adeno associated virus (rAAVs) gene therapies require adapting the transfection conditions of the upstream HEK293 cultivations. This study adopts an iterative model‐based experiment design approach, where increasing data availability is leveraged to evolve models of different complexity ...
Claudio Müller, Gerald Siegwart, Susanne Heider, Michael Sokolov, Angela Botros, Alexandra Umprecht, Moritz von Stosch, Mariano Nicolas Cruz Bournazou   +7 more
wiley   +1 more source

Recruitment of wild-type and recombinant adeno-associated virus into adenovirus replication centers

, 1996
Matthew D. Weitzman, Krishna J. Fisher, James M. Wilson   +2 more
openalex   +1 more source

Continuous purification of a parvovirus using two aqueous two‐phase extraction steps

Biotechnology Progress, EarlyView.
Abstract Aqueous two‐phase systems (ATPS) are a liquid–liquid extraction method that offers low‐cost, continuous‐adaptable virus purification. A two‐step ATPS using polyethylene glycol (PEG) and sodium citrate that recovered 66% of infectious porcine parvovirus with 2.0 logs of protein removal and 1.0 logs of DNA removal in batch has now been run ...
Natalie M. Nold, Sheridan Waldack, Grace James, Trisha Colling, Lynn Manchester, Taravat Sarvari, Amanda Bekkala, Seth A. Kriz, Madison Baldwin, Emily Agustin‐Mazariegos, Michael J. Betenbaugh, Caryn L. Heldt   +11 more
wiley   +1 more source

My Pathway to Adeno-Associated Virus and Adeno-Associated Virus Gene Therapy: A Personal Perspective

Human Gene Therapy, 2020
openaire   +3 more sources