PLAGL1 overexpression exacerbates type 1 diabetes by inducing β-cell apoptosis via oxidative stress-dependent dual DNA damage and cGAS/STING pathway activation. [PDF]
J Diabetes InvestigABSTRACT Background Type 1 diabetes mellitus (T1DM) arises from autoimmune destruction of pancreatic β‐cells. Pleomorphic adenoma gene‐like 1 (PLAGL1) overexpression has been linked to β‐cell apoptosis, but molecular mechanisms remain incompletely understood.
Li C +6 more
europepmc +3 more sources
CT and MRI Manifestations of Pancreatic Hemangioma: A Literature Review and a New Case Report. [PDF]
Clin Case RepABSTRACT Pancreatic hemangioma is an extremely rare benign tumor occurring in the pancreas. Preoperative diagnosis is challenging due to its lack of specificity in clinical manifestations and imaging examinations. A pancreatic lesion was found during physical examination of a 54‐year‐old woman who had no symptoms of abdominal discomfort.
Zhang J, Chen J, Zou D, Cao X.
europepmc +2 more sources
An Often Missed Cause of Chronic Pancreatitis: A Case Report on the Rare Presentation of Primary Hyperparathyroidism. [PDF]
Clin Case RepABSTRACT A 30‐year‐old woman with recurrent pancreatitis and nephrolithiasis was diagnosed with chronic calcific pancreatitis linked to primary hyperparathyroidism (PHPT). Following decompression of the pancreas and parathyroidectomy, her symptoms resolved and PTH levels normalized.
Ibraheem K +5 more
europepmc +2 more sources
New Insight on Insulinoma Treatment in a Pet Rat—A Case Report
Animals, 2022 Insulinomas are insulin-producing tumors of pancreatic beta cells that cause hypoglycemia. They are extremely common in ferrets but have also been reported in guinea pigs and rats.
Agata Godlewska +3 more
doaj +1 more source
Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion. [PDF]
PLoS Biology, 2007 Tumors develop through multiple stages, implicating multiple effectors, but the tools to assess how candidate genes contribute to stepwise tumor progression have been limited. We have developed a novel system in which progression of phenotypes in a mouse
Yi-Chieh Nancy Du +3 more
doaj +1 more source
Serous Microcystic Adenoma of Pancreas: A Case Series from a Tertiary Care Centre in Southern India [PDF]
Journal of Clinical and Diagnostic Research, 2017 Serous microcystic adenoma is a rare exocrine tumour of the cystic neoplasm of pancreas seen predominantly in the elderly population. The first patient was a 56-year-old diabetic woman with abdominal pain, constipation and loss of weight since two ...
K Rajasree Varma +3 more
doaj +1 more source
An interesting case of malignant paraganglioma of the mandible with calvarial metastasis
Journal of Indian Academy of Oral Medicine and Radiology, 2018 Paraganglioma is a rare neuroendocrine tumor arising from the neuroectodermally derived paraganglionic cells scattered throughout the body. Other neuroendocrine tumors include carcinoids, islet cell tumors, medullary carcinoma of thyroid, melanoma ...
Ravi Prakash Sasankoti Mohan +3 more
doaj +1 more source
Hypoglycaemic crisis induced by non-islet cell tumours in two dogs
Veterinární Medicína, 2019 Two dogs were admitted for the diagnosis and treatment of neoplasia (a hepatic and a mammary tumour, respectively), lethargy, quadriparesis and abnormal mentation with hypoglycaemia.
Hakhyun Kim +3 more
doaj +1 more source
Expression of transcription factors in MEN1-associated pancreatic neuroendocrine tumors
Endocrinology, Diabetes & Metabolism Case Reports, 2017 MEN1-associated pancreatic neuroendocrine tumors (pNETs) may potentially express distinct hormones, but the mechanism has not been elucidated. Transcription factors such as MafA and Pdx1 have been identified to lead to beta cell differentiation, while ...
Yasutaka Takeda +10 more
doaj +1 more source
Latent autoimmune diabetes of adulthood: case report
Clinical Diabetes and Endocrinology, 2017 Background Primary care clinicians will see a higher incidence of type 2 diabetes in adult patients, and the diagnosis and management of an initial presentation of type 1 diabetes can pose challenges to clinicians who see it less frequently.
Cristen P. Page +2 more
doaj +1 more source