Results 71 to 80 of about 34,616 (236)

Holistic bone developing microenvironment engineered apoptotic extracellular vesicles recapitulate multidimensional developmental signatures in adult and senile bone repair

Interdisciplinary Medicine, EarlyView.
The developing bone was identified as an M2a‐like macrophage driven immune microenvironment with multidimensional developmental signatures. hME‐ApoEVs were successfully fabricated via stimulating the M2a‐like developing microenvironment in vitro and confirmed its recapitulation of developmental features.
Xiaoran Yu, Jieyun Xu, Yuan Zhao, Xinyu Guo, Hongcheng Chen, Junlong Xue, Yong Ao, Linjun Zhang, Xiaomeng Gao, Xueli Mao, Songtao Shi, Zetao Chen   +11 more
wiley   +1 more source

A Novel Germline Mutation of the APC Gene: A Case Report of Familial Adenomatous Polyposis Requiring Repeated Endoscopic Resections for Gastroduodenal Polyps

The Korean Journal of Helicobacter and Upper Gastrointestinal Research, 2016
Familial adenomatous polyposis (FAP) is a precancerous clinical entity, which is characterized by the development of numerous adenomatous polyps throughout the colon and rectum.
Jun Hui Lee, Joon Weon Jang, Byung-Wook Kim, Eun Su Park, Sang Yong Kim   +4 more
doaj   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium [PDF]

, 2016
Aberrant Wnt signaling within breast cancer is associated with poor prognosis, but regulation of this pathway in breast tissue remains poorly understood and the consequences of immediate or long-term dysregulation remain elusive.
A Grigoriadis, A Imbert, A R Clarke, A Tanaka, AC Lesko, AI Khramtsov, AK Rajasekaran, AM Hassanein, AM Thompson, AR Moser, B Mann, BM Gumbiner, C Curtis, C S Daly, Cancer Genome Atlas N, CR Jarrett, CV Dang, D Sarrió, DJ Liao, DM Roberts, E López-Knowles, FC Geyer, G T Williams, H Clevers, H Clevers, H Clevers, I Van der Auwera, J H Van Es, J Quist, J Schneikert, J Watkins, JH van Es, JI Herschkowitz, JI Yook, JN Hutchinson, JS Michaelson, K Aoki, K Bray, K Furuuchi, K R Reed, K Umeda, K Wang, KY Ho, L D Ordonez, M Dolled-Filhart, M Jönsson, M Kashiwaba, M Reichert, M van der Meer, MM Suzuki, OJ Sansom, P Shaw, PW Schlosshauer, RA Neese, RC Gallagher, RS Chapman, S Irshad, S Khalil, S Mohinta, S Nelson, S Selbert, SB Sobottka, SJ Zardawi, SY Lin, TA Chan, TA DiMeo, TC He, TL Yang, TM Williams, Y Ahmed, Y Ando-Akatsuka, Z Jin, ZJ Wang   +72 more
core   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Perekondlik adenomatoosne polüpoos: ülevaade ja ühe perekonna haigusjuht [PDF]

, 2015
Perekondlik adenomatoosne polüpoos ( familial adenomatous polyposis, FAP) on kõige sagedasem päriliku polüpoosi sündroom ning haigusega kaasneb väga suur risk haigestuda jämesoolevähki.
Laidre, Piret, Mirka, Gerli, Raime, Kairi, Roomere, Hanno, Soplepmann, Jaan, Uibo, Oivi, Yakoreva, Maria, Õunap, Katrin   +7 more
core   +2 more sources

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

A Novel Germline Mutation in Exon 15 of the APC Gene in Attenuated Familial Adenomatous Polyposis: A Report of Two Cases

Gut and Liver, 2013
Attenuated familial adenomatous polyposis (AFAP) is a variant of familial adenomatous polyposis with fewer than one hundred colorectal polyps and a later age of onset of the cancer. Here, we report two cases of AFAP within family members.
doaj   +1 more source

Glucose Metabolism Regulating Colorectal Cancer Initiation and Progression

Cancer Science, EarlyView.
Drugs and compounds targeting glycolysis in CRC and the mechanisms by which these drugs inhibit their respective targets. ABSTRACT Colorectal cancer (CRC) is one of the most common types of invasive cancer worldwide, which has the characteristics of poor curative effect and poor prognosis. Increasing evidence suggests that hyperactivated glucose uptake
Meiyi Lin, Junpeng Cui
wiley   +1 more source

Intramucosal Colon Cancer Developing in an Inverted Hyperplastic Polyp

Gut and Liver, 2013
Attenuated familial adenomatous polyposis (AFAP) is a variant of familial adenomatous polyposis with fewer than one hundred colorectal polyps and a later age of onset of the cancer. Here, we report two cases of AFAP within family members.
doaj   +1 more source