Results 81 to 90 of about 34,616 (236)

Availability Of Dental Anomaly Phenotype In Individuals With Familial Adenomatous Polyposis [PDF]

, 2014
Background: Mutations in the APC gene cause familial adenomatous polyposis (FAP), an autosomal dominant colorectal cancer predisposition associated with the development of hundreds to thousands of adenomatous colorectal polyps beginning in childhood or ...
Lewis, Andrea M
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Low-level APC mutational mosaicism is the underlying cause in a substantial fraction of unexplained colorectal adenomatous polyposis cases

, 2015
BACKGROUND: In 30-50% of patients with colorectal adenomatous polyposis, no germline mutation in the known genes APC, causing familial adenomatous polyposis, MUTYH, causing MUTYH-associated polyposis, or POLE or POLD1, causing polymerase-proofreading ...
Adam, R., Aretz, S., Becker, T., Drichel, D., Hoffmann, P., Holinski-Feder, E., Holzapfel, S., Horpaopan, S., Kerick, M., Kirfel, J., Kristiansen, G., Laner, A., Lifton, R., Nöthen, M., Perner, S., Peters, S., Schweiger, M., Spier, I., Timmermann, B., Zhao, B.   +19 more
core   +1 more source

Wnt signalling in intestinal stem cells: lessons from mice and flies [PDF]

, 2018
Adult stem cells play critical roles in the basal maintenance of tissue integrity, also known as homeostasis, and in tissue regeneration following damage. The highly conserved Wnt signalling pathway is a key regulator of stem cell fate.
Carroll, Lynsey, Cordero, Julia, Perochon, Jessica   +2 more
core   +2 more sources

Targeting Inflammation and Immune Regulation in Chronic Inflammation Associated Cancers

Cancer Science, EarlyView.
Chronic inflammation sustains activation of key inflammatory pathways, including Nuclear factor kappa B (NF‐κB), Interleukin‐6‐signal transducer and activator of transcription 3 (IL6‐STAT3), Phosphoinositide 3‐kinase/Akt (PI3K/Akt), and Wingless/β‐catenin (Wnt/β‐catenin) signaling. This promotes immune dysregulation through the expansion and functional
Lawan Rabiu, Mengzhu Chinn, Feng Chen, Yerkezhan Yerkinkazhina, Yuan Tian, Wei‐Guo Zhu   +5 more
wiley   +1 more source

The fluctuation of APC gene in WNT signaling with adenine deletion of adenomatous polyposis coli, is associated in colorectal cancer

Journal of Coloproctology, 2020
Colorectal cancer is one of the most important malignancies in the classification of gastrointestinal cancers. One of the predisposing factors at molecular level for this cancer is via WNT signaling which is associated with the vast numbers of different ...
Seyedeh Elham Norollahi, Seyed Mohammad Taghi Hamidian, Zeynab Khazaee Kohpar, Rezvan Azadi, Pooya Rostami, Sogand Vahidi, Sahar Ghazanfari, Farnaz Azar Shabe, Roya Khaksar, Ali Akbar Samadani   +9 more
doaj   +1 more source

Beyond the chaos: How architecture structures tumour biology

The FEBS Journal, EarlyView.
Tissue architecture shapes tumour initiation and progression through multiple interconnected layers continuously remodelled over time. This review outlines how physical forces, biochemical cues, cellular niches and systemic influences contribute to tumour evolution.
Lea Dörner, Catrin Lutz, Stefan Prekovic, Hendrik A. Messal   +3 more
wiley   +1 more source

Progression of duodenal adenomatosis in familial adenomatous polyposis: due to ageing of subjects and advances in technology [PDF]

, 2011
Familial adenomatous polyposis patients are at risk of duodenal cancer. Surveillance is indicated and the extent of duodenal polyposis is quantified by the Spigelman staging system.
Elisabeth M. H. Mathus-Vliegen, Karam S. Boparai, Evelien Dekker, Nan van Geloven   +3 more
core   +2 more sources

The Role of Wnt Signaling in Age‐Related Alveolar Bone Loss and Regeneration

Journal of Periodontal Research, EarlyView.
The graphical abstract summarizes key signaling pathways involved in bone formation and resorption associated with Wnt signaling across young and aged long bone and jaw tissues. Levels of evidence are indicated as robust, moderate, or emerging, reflecting the current experimental support in each context.
Hsiao H. Sung, Navya Chalamalasetty, Ali Alzainal, Hanlong Liu, Lexuan Wang, Pietra Colacrai Arikita, Ivy C. X. Wei, Hom‐Lay Wang, M. H. J. van den Bosch, Michelle S. Caird, Peter M. van der Kraan, Kenneth M. Kozloff, Esmeralda Blaney Davidson   +12 more
wiley   +1 more source

Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization

Cell Reports, 2017
Adenomatous polyposis coli (APC) is a polarity regulator and tumor suppressor associated with familial adenomatous polyposis and colorectal cancer development.
Sonia Agüera-González, Oliver T. Burton, Elena Vázquez-Chávez, Céline Cuche, Floriane Herit, Jérôme Bouchet, Rémi Lasserre, Iratxe del Río-Iñiguez, Vincenzo Di Bartolo, Andrés Alcover   +9 more
doaj   +1 more source

Recognition and management of hereditary colorectal cancer syndromes [PDF]

, 2009
Over 1,900 colorectal tumors will arise in association with a hereditary colorectal cancer syndrome in Spain in 2009. The genetic defects responsible for the most common syndromes have been discovered in recent years. Genetic testing
Herraiz-Bayod, M.J. (Maite J.), Muñoz-Navas, M. (Miguel)   +1 more
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