Phosphatemia is an Independent Prognostic Factor in Amyotrophic Lateral Sclerosis
Annals of Neurology, EarlyView.Objective The objective of this study was to evaluate the prognostic value of several muscle damage biomarkers. Methods Data from Piemonte and Valle d'Aosta Amyotrophic Lateral Sclerosis (PARALS) were considered for this study. Survival was defined as the time from diagnosis to death, tracheostomy, or the censoring date.
Rosario Vasta +18 more
wiley +1 more source
New Transferrin Receptor‐Targeting Conjugate Effectively Delivers DNA to Mouse Brain
Angewandte Chemie, EarlyView.We present a novel RNA aptamer targeting the transferrin receptor (TfR), conjugated with DSPE lipid, which achieves remarkably efficient brain uptake, reaching brain‐to‐serum ratios as high as 6.5. Through fluorescence imaging and polymerase‐chain reaction analyses, we verify that this new conjugate successfully delivers a substantial amount of DNA ...
Min‐sun Song +8 more
wiley +2 more sources
The Effects of Storage Conditions and Homogenisation Buffers on the Measurement of SOD, CAT and ADA Enzyme Activities in Cattle Liver. [PDF]
Vet Med SciBalkan BM +5 more
europepmc +1 more source
The Comprehensive Roadmap Toward Malaria Elimination Using Graphene and its Promising 2D Analogs
Advanced NanoBiomed Research, EarlyView.Material based on a diversity of graphene with chemical properties of strong strength, high mobility, high transparency, good heat conductivity, biocompatibility, and chemical stability, advanced devices demonstrating antimalarial characteristics can be used for malaria treatment at different stages of malaria development from the injection of ...
Fangzhou He +11 more
wiley +1 more source
Ribozyme‐Catalyzed Site‐Specific Labeling of RNA Using O6‐alkylguanine SNAP‐Tag Substrates
Angewandte Chemie, EarlyView.SNAPR is a ribozyme that repurposes O6‐benzylguanine SNAP‐tag substrates for site‐specific labeling of RNA with bioorthogonal alkyne and azide functional groups, fluorophores or photocrosslinkers. The N1A‐alkylated RNA products were converted to N6A‐modified RNA by Dimroth rearrangement.
Manisha B. Walunj +3 more
wiley +2 more sources
The Organogermanium Compound 3-(trihydroxygermyl)propanoic Acid Exerts Anti-Inflammatory Effects via Adenosine-NR4A2 Signaling. [PDF]
Int J Mol SciAzumi J +5 more
europepmc +1 more source
Advanced NanoBiomed Research, EarlyView.Lanthanide‐based luminescence nanothermometry holds multifaceted potential for nanomedical applications, yet despite significant research advances, clinical translation of the engineered nanomaterials is still controversial and widely disputed. This is related to crucial nanotoxicological aspects that must be addressed at the preclinical level ...
Simona Premcheska +2 more
wiley +1 more source
Adenosine A1 receptor agonist alleviates cerebral ischemia/reperfusion injury by inhibiting Nrf2/NLRP3 signaling‑mediated pyroptosis. [PDF]
Exp Ther MedMing Q, Li Z, Tan J, Li Y.
europepmc +1 more source
Advanced NanoBiomed Research, EarlyView.Cancer cell membrane‐based nanoparticles (CCM‐NPs) and cancer cell‐derived small extracellular vesicles (CsEVs) are emerging as promising drug delivery systems for targeted cancer treatment. Advances in nanotechnology have paved the way for innovative drug delivery systems that enhance the effectiveness of cancer treatment.
Wei Zhang +4 more
wiley +1 more source
Structural Basis for the Catalytic Mechanism of ATP‐Dependent Diazotase CmaA6
Angewandte Chemie, EarlyView.Several diazotases have been reported in recent years, but the detailed catalytic mechanism is unclear. From X‐ray crystallography and Cryo‐EM analysis, we obtained the structure of a diazotase CmaA6, which synthesizes 3‐diazocoumaric acid. Kinetic analysis and computational analysis indicated that CmaA6 catalyzes diazotization via an unprecedented ...
Seiji Kawai +5 more
wiley +2 more sources