Clinical benefit of adenosine as an adjunct to reperfusion in ST-elevation myocardial infarction patients: An updated meta-analysis of randomized controlled trials [PDF]
, 2015 Background: Adenosine administered as an adjunct to reperfusion can reduce coronary no-reflow and limit myocardial infarct (MI) size in ST-segment elevation myocardial infarction (STEMI) patients. Whether adjunctive adenosine therapy can improve clinical
Bulluck, Heerajnarain +5 more
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A2AR Adenosine Signaling Suppresses Natural Killer Cell Maturation in the Tumor Microenvironment.
Cancer Research, 2018 Extracellular adenosine is a key immunosuppressive metabolite that restricts activation of cytotoxic lymphocytes and impairs antitumor immune responses.
A. Young +16 more
semanticscholar +1 more source
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1998 ABSTRACT:Background:Adenosine is a powerful natural vasodilator that participates in the control of cerebral and meningeal blood flow. In this context, it could be involved in the pathophysiology of migraine, since it was previously reported that intravenous adenosine can precipitate crises in migraine patients.Methods:We have investigated circulating ...
R. Gola +9 more
openaire +3 more sources
Metabolic and functional consequences of cytosolic 5′-nucleotidase-IA overexpression in neonatal rat cardiomyocytes [PDF]
, 2003 Adenosine exerts a spectrum of energy-preserving actions on the heart negative chronotropic effects. The pathways leading to adenosine formation have remained controversial.
Curto, Maria de Los Angeles +3 more
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Ultraslow water-mediated transmembrane interactions regulate the activation of A$_{\text{2A}}$ adenosine receptor [PDF]
Biophys. J. (2016) vol. 111, 1180-1191, 2016 Water molecules inside G-protein coupled receptor have recently been spotlighted in a series of crystal structures. To decipher the dynamics and functional roles of internal waters in GPCR activity, we studied A$_{\text{2A}}$ adenosine receptor using $\mu$sec-molecular dynamics simulations.
arxiv +1 more source
Adenosine, ‘pertussis-sensitive’ G-proteins, and K+ conductance in central mammalian neurones under energy deprivation [PDF]
, 1989 There is a striking similarity between the effects of adenosine and of hypoxia or glucose depletion on membrane potential and conductance of hippocampal neurones in tissue slices of rat brain.
A. Spuler +15 more
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A protein binding assay for adenosine 3':5'-cyclic monophosphate.
Proceedings of the National Academy of Sciences of the United States of America, 1970 A simple and sensitive assay for adenosine 3':5'-cyclic monophosphate (cAMP) has been developed that is based on competition for protein binding of the nucleotide, presumably to a cAMP-dependent protein kinase.
A. Gilman
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Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R [PDF]
, 2015 Adenosine is a widespread neuromodulator within the CNS and its extracellular level is increased during hypoxia or intense synaptic activity, modulating pre- and postsynaptic sites.
BERTOLLINI, Cristina +7 more
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Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome
Nature Communications, 2019 Potentiation of neutrophil extracellular trap (NET) release is one mechanism by which antiphospholipid antibodies (aPL Abs) effect thrombotic events in patients with antiphospholipid syndrome (APS).
R. Ali +12 more
semanticscholar +1 more source
Role of Adenosine in Epilepsy and Seizures.
Journal of Caffeine and Adenosine Research, 2020 Adenosine is an endogenous anticonvulsant and neuroprotectant of the brain. Seizure activity produces large quantities of adenosine, and it is this seizure-induced adenosine surge that normally stops a seizure.
F. Tescarollo +8 more
semanticscholar +1 more source