Frontiers in Cellular Neuroscience, 2022 Adenine nucleotides, such as adenosine triphosphate (ATP), adenosine diphosphate (ADP), as well as the nucleoside adenosine are important modulators of neuronal function by engaging P1 and P2 purinergic receptors.
Charlotte Schubert +8 more
doaj +1 more source
Inadequate response to adenosine infusion during cardiac stress magnetic resonance imaging
Annals of Cardiac Anaesthesia, 2022 Aim: To determine the factors associated with an inadequate response to adenosine infusion during cardiac stress magnetic resonance imaging (MRI). Study Design: It is a retrospective cohort study. Introduction: Stress cardiac MRI is a highly accurate and
Slomi Gupta +6 more
doaj +1 more source
Metabolic and functional consequences of cytosolic 5′-nucleotidase-IA overexpression in neonatal rat cardiomyocytes [PDF]
, 2003 Adenosine exerts a spectrum of energy-preserving actions on the heart negative chronotropic effects. The pathways leading to adenosine formation have remained controversial.
Curto, Maria de Los Angeles +3 more
core +1 more source
Clinical benefit of adenosine as an adjunct to reperfusion in ST-elevation myocardial infarction patients: An updated meta-analysis of randomized controlled trials [PDF]
, 2015 Background: Adenosine administered as an adjunct to reperfusion can reduce coronary no-reflow and limit myocardial infarct (MI) size in ST-segment elevation myocardial infarction (STEMI) patients. Whether adjunctive adenosine therapy can improve clinical
Bulluck, Heerajnarain +5 more
core +2 more sources
Purinergic Signaling in the Pathophysiology and Treatment of Huntington’s Disease
Frontiers in Neuroscience, 2021 Huntington’s disease (HD) is a devastating, progressive, and fatal neurodegenerative disorder inherited in an autosomal dominant manner. This condition is characterized by motor dysfunction (chorea in the early stage, followed by bradykinesia, dystonia ...
Melissa Talita Wiprich +4 more
doaj +1 more source
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1998 ABSTRACT:Background:Adenosine is a powerful natural vasodilator that participates in the control of cerebral and meningeal blood flow. In this context, it could be involved in the pathophysiology of migraine, since it was previously reported that intravenous adenosine can precipitate crises in migraine patients.Methods:We have investigated circulating ...
R. Gola +9 more
openaire +3 more sources
Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R [PDF]
, 2015 Adenosine is a widespread neuromodulator within the CNS and its extracellular level is increased during hypoxia or intense synaptic activity, modulating pre- and postsynaptic sites.
BERTOLLINI, Cristina +7 more
core +1 more source
Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities
Frontiers in Pharmacology, 2020 The outbreak of the novel coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) requires urgent clinical interventions.
Jonathan D. Geiger +4 more
doaj +1 more source
Ultraslow water-mediated transmembrane interactions regulate the activation of A$_{\text{2A}}$ adenosine receptor [PDF]
Biophys. J. (2016) vol. 111, 1180-1191, 2016 Water molecules inside G-protein coupled receptor have recently been spotlighted in a series of crystal structures. To decipher the dynamics and functional roles of internal waters in GPCR activity, we studied A$_{\text{2A}}$ adenosine receptor using $\mu$sec-molecular dynamics simulations.
arxiv +1 more source
Adenosine, ‘pertussis-sensitive’ G-proteins, and K+ conductance in central mammalian neurones under energy deprivation [PDF]
, 1989 There is a striking similarity between the effects of adenosine and of hypoxia or glucose depletion on membrane potential and conductance of hippocampal neurones in tissue slices of rat brain.
A. Spuler +15 more
core +1 more source