Results 41 to 50 of about 559,924 (346)
Adenosine and Adenosine Receptors: Advances in Atrial Fibrillation
Biomedicines, 2022 Atrial fibrillation (AF) is the most common arrhythmia in the world. Because the key to developing innovative therapies that limit the onset and the progression of AF is to fully understand the underlying molecular mechanisms of AF, the aim of the present narrative review is to report the most recent advances in the potential role of the adenosinergic ...
Baptiste Maille +12 more
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General anesthesia or conscious sedation in paroxysmal atrial fibrillation catheter ablation
Biomedical Papers, 2021 Background. Catheter ablation of paroxysmal atrial fibrillation (AF) can be performed under general anesthesia or conscious sedation. The influence of type of anesthesiology care on procedural characteristics and ablation outcome in patients in whom ...
Ondrej Moravec +10 more
doaj +1 more source
Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome
Nature Communications, 2019 Potentiation of neutrophil extracellular trap (NET) release is one mechanism by which antiphospholipid antibodies (aPL Abs) effect thrombotic events in patients with antiphospholipid syndrome (APS).
R. Ali +12 more
semanticscholar +1 more source
Adenosine Dysfunction and Adenosine Kinase in Epileptogenesis [PDF]
The Open Neuroscience Journal, 2010 Traditionally, epilepsy has been considered to be a disorder of neuronal dysfunction. Based on this dogma, drug development efforts have largely focused on neurocentric model systems to screen for compounds that affect the function of neurons. Unfortunately, about 30% of all patients with epilepsy - or more than 20 million worldwide - are refractory to
openaire +3 more sources
Purinergic Signaling in the Pathophysiology and Treatment of Huntington’s Disease
Frontiers in Neuroscience, 2021 Huntington’s disease (HD) is a devastating, progressive, and fatal neurodegenerative disorder inherited in an autosomal dominant manner. This condition is characterized by motor dysfunction (chorea in the early stage, followed by bradykinesia, dystonia ...
Melissa Talita Wiprich +4 more
doaj +1 more source
Journal of Experimental Medicine, 1997 Apoptosis and necrosis are considered conceptually and morphologically distinct forms of cell death. Here, we report that demise of human T cells caused by two classic apoptotic triggers (staurosporin and CD95 stimulation) changed from apoptosis to ...
M. Leist +4 more
semanticscholar +1 more source
Role of Adenosine in Epilepsy and Seizures.
Journal of Caffeine and Adenosine Research, 2020 Adenosine is an endogenous anticonvulsant and neuroprotectant of the brain. Seizure activity produces large quantities of adenosine, and it is this seizure-induced adenosine surge that normally stops a seizure.
F. Tescarollo +8 more
semanticscholar +1 more source
Frontiers in Immunology, 2019 Tumor microenvironments are rich in extracellular nucleotides that can be metabolized by ectoenzymes to produce adenosine, a nucleoside involved in controlling immune responses.
Alberto L. Horenstein +6 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2021 Adenosine, a major neuromodulator in the central nervous system (CNS), is involved in a variety of regulatory functions such as the sleep/wake cycle.
Jiexin Cao +2 more
doaj +1 more source
Frontiers in Neuroscience, 2019 Histone methylation/demethylation plays an important modulatory role in chromatin restructuring, RNA transcription and is essential for controlling a plethora of biological processes.
Eric Murillo-Rodríguez +23 more
doaj +1 more source