Results 61 to 70 of about 559,924 (346)

An unexpected response to adenosine [PDF]

Netherlands Heart Journal, 2014
Rhythm puzzle—answer The ECG shown in Fig. 1 is a narrow complex tachycardia with a frequency of 270 beats/min. Contradictory to expectations, the administration of adenosine resulted not in conversion of the arrhythmia, but in this accelerated rhythm, making an AV(N)RT unlikely.
R. G. Tieleman, J. M. ter Maaten
openaire   +5 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Inadequate response to adenosine infusion during cardiac stress magnetic resonance imaging

Annals of Cardiac Anaesthesia, 2022
Aim: To determine the factors associated with an inadequate response to adenosine infusion during cardiac stress magnetic resonance imaging (MRI). Study Design: It is a retrospective cohort study. Introduction: Stress cardiac MRI is a highly accurate and
Slomi Gupta, Parimala Prasanna Simha, Naveen G Singh, P S Nagaraja, Ashita Barthur, Kartik Ganga, V Prabhakar   +6 more
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Aspectos relevantes de la S-adenosilhomocisteína hidrolasa relacionados con el metabolismo de la S-adenosilhomocisteína Relevant aspects of S-adenosylhomocysteine hydrolase related to the metabolism of S-adenosylhomocysteine

Revista Cubana de Investigaciones Biomédicas, 2006
Se realizó una revisión de la S-adenosil metionina, considerado como el donante fundamental de grupos metilo en el organismo. Por una reacción de transmetilación es obtenida la S-adenosil homocisteína, que es un potente inhibidor de transmetilasas ...
Yelamy Travieso González, Pavel Mustelier Zamora, Zonia Martínez Benítez, Aimé Posada García   +3 more
doaj  

Research progress on adenosine in central nervous system diseases

CNS Neuroscience & Therapeutics, 2019
As an endogenous neuroprotectant agent, adenosine is extensively distributed and is particularly abundant in the central nervous system (CNS). Under physiological conditions, the concentration of adenosine is low intra‐ and extracellularly, but increases
Yingjiao Liu, Jiao Chen, Xun Li, Xin Zhou, Yaomei Hu, Shi-Feng Chu, Ye Peng, N. Chen   +7 more
semanticscholar   +1 more source

Adenosine and anergy

Autoimmunity, 2007
T cells must integrate multiple environmental cues when deciding whether to mount an immunogenic or tolerogenic response. Since not all self-reactive T cells are eliminated during thymic development, mechanisms of peripheral tolerance such as T cell anergy contribute to preventing autoimmunity. Recent studies have implicated extracellular adenosine and
Paul E. Zarek, Jonathan D. Powell
openaire   +3 more sources

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Profiling the effect of low frequency mechanical vibration on the metabolic and oxidative stress responses of A431 carcinoma

FEBS Open Bio, EarlyView.
20 Hz mechanical vibration induced A431 cancer cells' apoptosis without such effect on other healthy cell lines of L929 and C2C12. Lowered glucose consumption is observed specifically in A431. The expressions of ROS, HMGB1, and HSP1 levels initially increase and subsequently decrease in the cancer cell line, as opposed to L929 and C2C12, which ...
Wresti L. Anggayasti, Chikahiro Imashiro, Takashi Morikura, Shogo Miyata, Akira Funahashi, Kenjiro Takemura   +5 more
wiley   +1 more source

Neuronal Adenosine A1 Receptor is Critical for Olfactory Function but Unable to Attenuate Olfactory Dysfunction in Neuroinflammation

Frontiers in Cellular Neuroscience, 2022
Adenine nucleotides, such as adenosine triphosphate (ATP), adenosine diphosphate (ADP), as well as the nucleoside adenosine are important modulators of neuronal function by engaging P1 and P2 purinergic receptors.
Charlotte Schubert, Kristina Schulz, Simone Träger, Anna-Lena Plath, Asina Omriouate, Sina C. Rosenkranz, Fabio Morellini, Manuel A. Friese, Daniela Hirnet   +8 more
doaj   +1 more source