Results 1 to 10 of about 31,304 (262)

Adenosine stimulates the basolateral 50 pS K+ channel in renal proximal tubule via adenosine-A1 receptor [PDF]

Frontiers in Physiology, 2023
Background: The basolateral potassium channels play an important role in maintaining the membrane transport in the renal proximal tubules (PT) and adenosine receptors have been shown to regulate the trans-epithelial Na+ absorption in the PT.
Hao Liu, Qi Sun, Zheng Ding, Wensen Shi, Wen-Hui Wang, Chengbiao Zhang   +5 more
doaj   +2 more sources

Immunolocalization of A1 Adenosine Receptors in Mammalian Spermatozoa [PDF]

Journal of Histochemistry & Cytochemistry, 2000
The presence of A1 adenosine receptors (A1AR) in mammalian spermatozoa was previously demonstrated by radiochemical and immunochemical detection. This study was performed to investigate the cellular location of the A1AR to determine whether these receptors were somehow connected with ecto-adenosine deaminase and to evaluate their function in calcium ...
Alba Minelli, Cinzia Allegrucci, Paola Piomboni, Roberta Mannucci, C. Lluís, Rafael Franco   +5 more
openalex   +5 more sources

Small molecule allosteric modulation of the adenosine A1 receptor [PDF]

Frontiers in Endocrinology, 2023
G protein-coupled receptors (GPCRs) represent the target for approximately a third of FDA-approved small molecule drugs. The adenosine A1 receptor (A1R), one of four adenosine GPCR subtypes, has important (patho)physiological roles in humans.
Anh T. N. Nguyen, Quan L. Tran, Jo-Anne Baltos, Samantha M. McNeill, Diep T. N. Nguyen, Lauren T. May   +5 more
doaj   +2 more sources

Long-term adenosine A1 receptor activation-induced sortilin expression promotes α-synuclein upregulation in dopaminergic neurons [PDF]

Neural Regeneration Research, 2020
Prolonged activation of adenosine A1 receptor likely leads to damage of dopaminergic neurons and subsequent development of neurodegenerative diseases.
Yun-Cheng Lv, An-Bo Gao, Jing Yang, Li-Yuan Zhong, Bo Jia, Shu-Hui Ouyang, Le Gui, Tian-Hong Peng, Sha Sun, Francisco S Cayabyab   +9 more
doaj   +2 more sources

Investigation of adenosine A1 receptor-mediated β-arrestin 2 recruitment using a split-luciferase assay. [PDF]

Front Pharmacol, 2023
Saecker L, Häberlein H, Franken S.
europepmc   +3 more sources

Adenosine Deaminase and A1 Adenosine Receptors Internalize Together following Agonist-induced Receptor Desensitization [PDF]

Journal of Biological Chemistry, 1998
A1 adenosine receptors (A1Rs) and adenosine deaminase (ADA; EC 3.5.4. 4) interact on the cell surface of DDT1MF-2 smooth muscle cells. The interaction facilitates ligand binding and signaling via A1R, but it is not known whether it has a role in homologous desensitization of A1Rs. Here we show that chronic exposure of DDT1MF-2 cells to the A1R agonist,
Carlos A. Saura, Josefa Mallol, Enric I. Canela, Carmen Lluís, Rafael Franco   +4 more
openalex   +5 more sources

Adenosine A1 Receptor Agonist 2-chloro-N6-cyclopentyladenosine and Hippocampal Excitability During Brain Development in Rats [PDF]

Frontiers in Pharmacology, 2019
Objective: The adenosinergic system may influence excitability in the brain. Endogenous and exogenous adenosine has anticonvulsant activity presumably by activating A1 receptors.
Petr Fabera, Petr Fabera, Martina Parizkova, Martina Parizkova, Libor Uttl, Libor Uttl, Katerina Vondrakova, Katerina Vondrakova, Hana Kubova, Grygoriy Tsenov, Grygoriy Tsenov, Pavel Mares   +11 more
doaj   +2 more sources

Adenosine A1 receptor (ADORA1) [PDF]

Science-Business eXchange, 2011

openalex   +3 more sources

Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation. [PDF]

Cell Rep Med
Zhu W, Hong Y, Tong Z, He X, Li Y, Wang H, Gao X, Song P, Zhang X, Wu X, Tan Z, Huang W, Liu Z, Bao Y, Ma J, Zheng N, Xie C, Ke X, Zhou W, Jia W, Li M, Zhong J, Sheng L, Li H.   +23 more
europepmc   +4 more sources

Dynamic allosteric networks drive adenosine A₁ receptor activation and G-protein coupling. [PDF]

Elife, 2023
Maria-Solano MA, Choi S.
europepmc   +3 more sources