The FEBS Journal, Volume 292, Issue 7, Page 1558-1572, April 2025.Breast cancer is a complex disease significantly influenced by estrogen receptors (ERs) and the extracellular matrix (ECM), both of which are critical in shaping tumor behavior. ERα and ERβ modulate cancer progression and therapeutic response with their interactions intricately linked to ECM dynamics.
Sylvia Mangani +4 more
wiley +1 more source
Dynamic allosteric networks drive adenosine A1 receptor activation and G-protein coupling. [PDF]
Elife, 2023 Maria-Solano MA, Choi S.
europepmc +1 more source
Involvement of adenosine A1 receptors in systemic inflammation and altered vascular reactivity in allergic mice [PDF]
, 2008 Epidemiological studies have established that people who have lung diseases such as asthma and COPD are likely to develop adverse cardiovascular events. While the reason for this has not been elucidated, it is believed that inflammation could be the key ...
Ponnoth, Dovenia S.
core +1 more source
Interplay between metabotropic glutamate type 4 and adenosine type 1 receptors modulate synaptic transmission in the cerebellar cortex [PDF]
The synapses between parallel fibers and Purkinje cells play a pivotal role in cerebellar function. They are intricately governed by a variety of presynaptic receptors, notably by type 4 metabotropic glutamate (mGlu4) receptors and type 1 adenosine (A1 ...
Bossi, Simon +2 more
core +2 more sources
Harnessing nucleotide metabolism and immunity in cancer: a tumour microenvironment perspective
The FEBS Journal, Volume 292, Issue 9, Page 2155-2172, May 2025.This review explores how changes in nucleotide metabolism affect the tumour microenvironment and immune responses in cancer. Here, we discuss the dual role of nucleotide metabolism in promoting cancer cell growth and shaping immune suppression. We highlight how therapies targeting nucleotide pathways can enhance immunotherapy efficacy, offering new ...
Hadil Suleiman +5 more
wiley +1 more source
Clues from a missense mutation of the adenosine A1 receptor gene associated with early-onset Parkinson's disease. [PDF]
Neural Regen Res, 2023 Ferré S, Pardo L, Ciruela F.
europepmc +1 more source
Design and synthesis of new fluorescent probes for A2B adenosine receptor. [PDF]
, 2014 Adenosine is an endogenous purine nucleoside that plays a key role in numerous important physiological functions through interactions with specific cell-surface G-protein-coupled receptors (GPCRs), which are classified into four subtypes, namely A1, A2A,
MORETTI, ELEONORA
core
The FEBS Journal, EarlyView.Decidualization is the process by which human endometrial stromal cells undergo morphological and functional changes to prepare the uterus for embryo implantation and support pregnancy. Our study identifies the phosphatidic acid‐Src‐FAK‐RhoA/ROCK signaling pathway as a critical regulator of the cytoskeletal alterations required for this transformation.
Hyeon‐Jeong Jun +5 more
wiley +1 more source
Derivatives of MOPS: promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition
The FEBS Journal, EarlyView.The SARS‐CoV/CoV‐2 genome encodes non‐structural protein 3, which contains a ‘Macro domain’. This protein domain exhibits antagonistic activity against interferon signaling, which disrupts the host innate immune response and can thus mediate viral escape, highlighting its therapeutic potential.
Oney Ortega Granda +5 more
wiley +1 more source
Adenosine A1 receptor ligands bind to α-synuclein: implications for α-synuclein misfolding and α-synucleinopathy in Parkinson's disease. [PDF]
Transl Neurodegener, 2022 Jakova E +4 more
europepmc +1 more source