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A1 Adenosine Receptors in Human Neutrophils
1998Adenosine is an ubiquitous nucleoside that mediates several important physiological effects, trough the binding of three pharmacologically distinct receptor subtypes, named A1 A2 and A 3 .1 Adenosine receptor subtypes has been distinguished on the basis of the effect of adenosine on the cellular content of cAMP: occupancy of A2 adenosine receptors ...
MARTINI, CLAUDIA +7 more
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Adenosine attenuates calcium paradox injury: role of adenosine A1 receptor
American Journal of Physiology-Cell Physiology, 1995The present study was conducted to test the hypothesis that adenosine attenuates the Ca2+ paradox (PD) injury via stimulation of adenosine A1 receptors linked to Gi proteins in the isolated rat heart. Treatment of adenosine reduced maximum lactate dehydrogenase release and ATP loss compared with regular Ca2+ PD.
J. Suleiman, M. Ashraf
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Evidence of A1 Adenosine Receptor on Epidydimal Bovine Spermatozoa
Archives of Biochemistry and Biophysics, 19953H-R-phenylisopropyladenosine (PIA) was used to characterize adenosine receptors on bovine epidydimal spermatozoa membranes. Dypiridamole, an adenosine uptake inhibitor, did not effect the radioligand binding, indicating an external site for the interaction of adenosine with spermatozoa.
MINELLI, Alba +3 more
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Desensitization of A1 Adenosine Receptors
1995It is well known that exposure of sensitive cells to receptor agonists can cause a progressive reduction in their capacity to respond to this and related agonists. This phenomenon has been observed with cells expressing receptors from different superfamilies, and has been termed desensitization, refractoriness,tolerance, or tachyphylaxis [1].
Edmund Hoppe, Martin J. Lohse
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Adenosine receptors on human leukocytes IV. characterization of an A1/Ri receptor
International Journal of Clinical & Laboratory Research, 1992Adenosine (10(-9)-10(-6) mol/l) and R-phenylisopropyladenosine (10(-9)-10(-7) mol/l) partially inhibited the intracellular accumulation of cyclic AMP induced by isoproterenol, prostaglandin E1, histamine and 5'-N-ethylcarboxamidoadenosine in lymphocytes.
Gianni Marone +4 more
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Xanthine derivatives as antagonists at A1 and A2 adenosine receptors
Naunyn-Schmiedeberg's Archives of Pharmacology, 1985A variety of alkylxanthines has been comparatively examined as antagonists of A1 adenosine receptors in rat fat cells, rat and bovine cerebral cortex and of A2 adenosine receptors in human platelets. With few exceptions all xanthine derivatives with 7-position substituents such as diprophylline, proxyfylline, pentoxifylline and etofylline were less ...
Martin J. Lohse +2 more
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Cardiovascular and Renal Effects of Blocking A1 Adenosine Receptors
Journal of Cardiovascular Pharmacology, 1993The primary objective of this study was to test the hypothesis that endogenous adenosine/A1 receptor interactions participate in the normal regulation of the cardiovascular system and kidneys. In anesthetized rats, we examined the effects of pharmacologically equivalent doses of DPCPX and FK453 (two structurally dissimilar A1 receptor antagonists) and ...
William A. Herzer +2 more
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Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-vornhagen +2 more
exaly