Results 191 to 200 of about 127,904 (323)

Adenosine receptor down-regulation and insulin resistance following prolonged incubation of adipocytes with an A1 adenosine receptor agonist.

, 1987
A Green
openalex   +1 more source

Agonists for the adenosine A1 receptor with tunable residence time. A Case for nonribose 4-amino-6-aryl-5-cyano-2-thiopyrimidines.

Journal of Medicinal Chemistry, 2014
Julien Louvel, D. Guo, M. Agliardi, Tamara A. M. Mocking, R. Kars, T. P. Pham, Lizi Xia, H. de Vries, J. Brussee, L. Heitman, A. IJzerman   +10 more
semanticscholar   +1 more source

Glabridin‐Gold(I) Complex as a Novel Immunomodulatory Agent Targeting TrxR and MAPK Pathways for Synergistic Enhancement of Antitumor Immunity

Advanced Science, Volume 12, Issue 41, November 6, 2025.
Complex 6d could promote tumor immunogenicity by targeting thioredoxin reductase (TrxR) and remodel immunosuppressive microenvironment by the mitogen‐activated protein kinase (MAPK) pathway inhibition simultaneously. This study provides a novel approach to develop metal immunomodulatory agents by designing gold complexes incorporating natural products,
Zhaoran Wang, Meiyu Wang, Qiong Chen, Mengshi Wang, Fuwei Li, Lin Lv, Zhenfan Wen, Zhongren Xu, Yixia Yang, Chunyang Bi, Wukun Liu   +10 more
wiley   +1 more source

A Chemical Biological Approach to Study G Protein-Coupled Receptors: Labeling the Adenosine A₁ Receptor Using an Electrophilic Covalent Probe. [PDF]

ACS Chem Biol, 2022
Beerkens BLH, Koç Ç, Liu R, Florea BI, Le Dévédec SE, Heitman LH, IJzerman AP, van der Es D.   +7 more
europepmc   +1 more source

Evaluation of chemical constituents of Rooibos (Aspalathus linearis) and Honeybush (Cyclopia intermedia) as adenosine A1/A2A receptor ligands [PDF]

, 2023
L. Gouws, Helena D. Janse van Rensburg, Gisella Terre’Blanche, Mietha M. Van der Walt   +3 more
openalex   +1 more source

Adenosine A1 receptor activation attenuates cardiac hypertrophy and fibrosis in response to α1‐adrenoceptor stimulation in vivo

British Journal of Pharmacology, 2015
S. Puhl, A. Kazakov, A. Müller, Peter Fries, D. Wagner, M. Böhm, Christoph Maack, Y. Devaux   +7 more
semanticscholar   +1 more source

Mechanism and role of regulated cell death in tumor immunity and immunotherapy

Cancer Communications, Volume 45, Issue 11, Page 1456-1495, November 2025.
Abstract Cancer immune checkpoint inhibitors (ICIs) have brought breakthroughs, but only about one‐third of cancer patients benefit from ICIs. In recent years, targeting non‐apoptotic regulated cell death (RCD) subtypes, such as ferroptosis, necroptosis, autophagy, cuproptosis, and pyroptosis, has emerged as a novel strategy in cancer therapy due to ...
Jingwen Hu, Yan Li, Bingjie Lian, Yitao Mao, Luqing Zhao   +4 more
wiley   +1 more source

Adenosine A₁ receptor antagonist-induced facilitation of postsynaptic AMPA currents in pyramidal neurons of the rat hippocampal CA2 area. [PDF]

Purinergic Signal, 2023
Kawamura M, Sekino Y.
europepmc   +1 more source

The Second Extracellular Loop of the Adenosine A1 Receptor Mediates Activity of Allosteric Enhancers

Molecular Pharmacology, 2014
Dylan P Kennedy, F. McRobb, S. Leonhardt, M. Purdy, H. Figler, Melissa A. Marshall, M. Chordia, R. Figler, J. Linden, R. Abagyan, M. Yeager   +10 more
semanticscholar   +1 more source

Cardiovascular Safety of VIAN‐c4551, an Antiangiogenic Peptide Derived From Vasoinhibin

Drug Development Research, Volume 86, Issue 7, November 2025.
ABSTRACT Vasoinhibin is a potent antiangiogenic protein that blocks the activation of endothelial nitric oxide synthase (eNOS) in response to vascular endothelial growth factor, bradykinin, and acetylcholine (ACh). In this regard, VIAN‐c4551, a new synthetic vasoinhibin analog, has therapeutic potential for targeting angiogenesis in oncology and ...
Miguel A. García‐González, Alejandro D. Miguel‐Martínez, Abimael González‐Hernández, Magdalena Zamora, Elva Adán‐Castro, Xarubet Ruíz‐Herrera, María A. Carbajo‐Mata, Jakob Triebel, Thomas Bertsch, José G. Lopez‐Lopez, Gonzalo Martínez de la Escalera, Juan Pablo Robles, Carmen Clapp, Carlos M. Villalón   +13 more
wiley   +1 more source