Results 51 to 60 of about 103,074 (260)

TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity

mAbs, 2022
Cluster of differentiation 38 (CD38) is an ecto-enzyme expressed primarily on immune cells that metabolizes nicotinamide adenine dinucleotide (NAD+) to adenosine diphosphate ribose or cyclic ADP-ribose and nicotinamide.
Harshad S. Ugamraj, Kevin Dang, Laure-Hélène Ouisse, Benjamin Buelow, Eduardo N. Chini, Giulia Castello, James Allison, Starlynn C Clarke, Laura M. Davison, Roland Buelow, Rong Deng, Suhasini Iyer, Ute Schellenberger, Sankar N. Manika, Shipra Bijpuria, Astrid Musnier, Anne Poupon, Maria Cristina Cuturi, Wim van Schooten, Pranjali Dalvi   +19 more
doaj   +1 more source

Adjunctive therapies to reduce thrombotic events in patients with a history of myocardial infarction : role of vorapaxar [PDF]

, 2015
© 2015 Farag et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) LicenseAcute myocardial infarction (AMI) is generally attributed to coronary atherothrombotic ...
Farag, Mohamed, Gorog, Diana A, Patel, Hiten   +2 more
core   +3 more sources

Enzymid dephosphorylation of adenosine diphosphate phosphoglyceric acid [PDF]

Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects, 1964
Abstract An enzyme from muscle which acts on adenosine diphosphate phosphoglyceric acid and leads to the hydrolysis of the phosphate group at the 2-position of the glyceric acid moiety has been studied. The enzyme is strongly stimulated by inorgamoc pyrophosphate. This action is very specific. The enzyme also acts on 2,3-diphosphoglycerate.
Zancan, Glaci T., Recondo, Eduardo F., Leloir, Luis Federico   +2 more
openaire   +4 more sources

Динамические способности и управление качеством [PDF]

, 2008
BACKGROUND: Mechanical ventilation can induce organ injury associated with overwhelming inflammatory responses. Excessive activation of poly(adenosine diphosphate-ribose) polymerase enzyme following massive DNA damage may aggravate inflammatory responses.
Chiang, Shyh Ren, Della Corte, Francesco, Haitsma, Jack J., Juco, Jonathan W., Kuiper, Jan W., Plötz, Frans B., Slutsky, Arthur S., Uhlig, Stefan, Vaschetto, Rosanna, Zhang, Haibo   +9 more
core   +2 more sources

Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase [PDF]

, 2007
This research was supported by the German Academic Exchange Service (DAAD), the Wellcome Trust (TKS and WNH as Trust Senior Research fellows), the Biotechnology and Biological Science Research Council (Structural Proteomics of Rational Targets) and the ...
Hunter, William N., Sgraja, Tanja, Smith, Terry K   +2 more
core   +2 more sources

Targeted LC-MS profiling reveals dysregulated glycolytic flux and TCA cycle stalling in POAG plasma

Scientific Reports
Glaucoma is the leading cause of irreversible blindness. Primary open-angle glaucoma (POAG) is the most common form globally and has been linked to mitochondrial dysfunction and energy deficiency.
Yizhen Tang, Xuanqi Zhang, Xiaoxiao Chen, Jiayong Li, Minyue Xie, Qianru Wu, Yinghan Zhang, Chi-wai Do, Xinghuai Sun   +8 more
doaj   +1 more source

P2 purinoceptors signaling in fibroblasts of rat subcutaneous tissue [PDF]

, 2011
Mestrado em Biologia Molecular e CelularO tecido conjuntivo parece estar envolvido na génese de diversas condições patológicas. O aumento da rigidez do tecido conjuntivo, resultante da fibrose, pode constituir um factor importante no mecanismo patogénico
Reis, Carla Patrícia da Silva e Sousa
core   +1 more source

ATPase mechanism of the 5'-3' DNA helicase, RecD2: evidence for a pre-hydrolysis conformation change [PDF]

, 2013
The superfamily 1 helicase, RecD2, is a monomeric, bacterial enzyme with a role in DNA repair, but with 5'-3' activity unlike most enzymes from this superfamily. Rate constants were determined for steps within the ATPase cycle of RecD2 in the presence of
Bae, Bird, Boulé, Brune, Brune, Cao, Chisty, Christopher P. Toseland, Cremo, Dillingham, Gu, Henn, Henn, Hiratsuka, Ivessa, Jameson, Leatherbarrow, Lohman, Manosas, Martin R. Webb, Moore, Nixon, Okoh, Rocha, Saikrishnan, Singleton, Slatter, Soultanas, Toseland, Toseland, Toseland, Toseland, Wang, Webb, Webb   +34 more
core   +1 more source

IS THE SYNTAX SCORE SUFFICIENT TO ASSESS THE RISK FOR PATIENTS UNDERGOING ELECTIVE PERCUTANEOUS CORONARY INTERVENTIONS?

Атеротромбоз, 2017
The article presents a comparative evaluation of the current clinical angiographic scales in the risk stratification for patients with stable coronary artery disease undergoing elective percutaneous coronary interventions.
E. S. Novikova, A. L. Komarov, E. V. Gus’kova, O. O. Shakhmatova, A. D. Deyev, A. B. Dobrovolsky, A. N. Samko, E. P. Panchenko   +7 more
doaj   +1 more source

Validation of a Fast and Simple HPLC-UV Method for the Quantification of Adenosine Phosphates in Human Bronchial Epithelial Cells

Molecules, 2021
A new HPLC method for the simultaneous quantitative analysis of adenosine triphosphate (ATP), adenosine diphosphate (ADP), and adenosine monophosphate (AMP) was developed and validated.
Ana Teresa Juarez-Facio, Violaine Martin de Lagarde, Christelle Monteil, Jean-Marie Vaugeois, Cécile Corbiere, Tiphaine Rogez-Florent   +5 more
doaj   +1 more source