Results 171 to 180 of about 34,973 (226)

Synthesis of Simple Adenosine Diphosphate Ribose Analogues

Nucleosides, Nucleotides and Nucleic Acids, 2008
[See figures]. The synthesis of analogues of adenosine diphosphate ribose and acetylated adenosine diphosphate ribose, modified at the northern pentose, is reported. The stereochemistry at the acetylated centers was chosen to minimize acetyl migration and dictated the overall synthetic strategy.
Olivier P Chevallier, Marie E Migaud
exaly   +4 more sources

Isopolar Phosphonate Analogue of Adenosine Diphosphate Ribose

Organic Letters, 2004
[structure: see text] The synthesis of the bisphosphonate ADP-ribose, in which acetylene has replaced the oxygen of the pyrophosphate linkage, is reported.
Migaud, Marie, Van Derpoorten, K.
openaire   +4 more sources

Changes in poly(adenosine diphosphate-ribose) and poly(adenosine diphosphate-ribose) polymerase in synchronous HeLa cells

Biochemistry, 1976
An antibody has been prepared which is highly specific for poly(adenosine diphosphate-ribose). Neither poly(A), DNA, nor a variety of adenine-containing nucleosides or nucleotides were effective in competing with poly(ADP-ribose) for binding to the antibody. Of all compounds tested, only adenosine diphosphate-ribose competed for binding to the antibody.
W R, Kidwell, M G, Mage
openaire   +3 more sources

Poly(adenosine diphosphate ribose)

Progress in Nucleic Acid Research and Molecular Biology, 1982
Publisher Summary This chapter discusses the higher-order structure of poly(adenosine diphosphate ribose) [poly(ADPR)], poly(ADPR) polymerase purification and its properties, and molecular mechanisms of histone- and elongation-factor (EF-2)-ADP-ribosylation.
P, Mandel, H, Okazaki, C, Niedergang
openaire   +3 more sources

HPLC analysis of cyclic adenosine diphosphate ribose and adenosine diphosphate ribose: determination of NAD+ metabolites in hippocampal membranes.

The Italian journal of biochemistry, 1995
Cyclic adenosine diphosphate-ribose (cADPR) and ADPR were separated by high-performance liquid chromatography (HPLC) on a CarboPac PA-1 column at strong basic pH and quantitated by a pulsed amperometric detector. Although this HPLC method was quite sensitive and highly reproducible, it did not allow the separation of cADPR from guanosine monophosphate (
G. CASABONA, L. STURIALE, M. R. LEPISCOPO, G. RACITI, A. FAZZIO, SARPIETRO, MARIA GRAZIA, A. A. GENAZZANI, A. CAMBRIA, F. NICOLETTI   +8 more
openaire   +6 more sources

Synthesis of a Bioreversibly Masked Lipophilic Adenosine Diphosphate Ribose Derivative

ChemBioChem, 2017
AbstractThe design of a bioreversibly protected lipophilic sugar nucleotide as a potential membrane‐permeable precursor of adenosine diphosphate ribose (ADPR) is described. ADPR is the most potent activator of the transient receptor potential melastatin 2 (TRPM2) ion channel.
Katharina, Pahnke, Chris, Meier
openaire   +3 more sources

Cyclic aristeromycin diphosphate ribose: A potent and poorly hydrolysable Ca2+-mobilising mimic of cyclic adenosine diphosphate ribose

FEBS Letters, 1996
Cyclic aristeromycin diphosphate ribose, a carbocyclic analogue of cyclic adenosine diphosphate ribose, was synthesised using a chemo-enzymatic route involving activation of aristeromycin 5′-phosphate by diphenyl phosphochloridate.
Antony Galione, Barry V L Potter
exaly   +2 more sources

Olaparib maintenance therapy in patients with platinum‐sensitive, relapsed serous ovarian cancer and a BRCA mutation: Overall survival adjusted for postprogression poly(adenosine diphosphate ribose) polymerase inhibitor therapy

Cancer, 2016
Charlie Gourley, Michael Friedlander, Gordon Rustin   +2 more
exaly   +2 more sources

Poly(adenosine diphosphate‐ribose) polymerase inhibitor combinations in first‐line metastatic castrate‐resistant prostate cancer setting: a systematic review and meta‐analysis

BJU International, 2023
To compare radiographic progression‐free survival (rPFS), overall survival (OS), and treatment‐emergent adverse events (TEAEs) among patients with metastatic castrate‐resistant prostate cancer (mCRPC) receiving a combination of first‐line poly(adenosine ...
R. Sayyid, Z. Klaassen, A. Berlin, Soumyajit Roy, L. Brandão, Rui M. Bernardino, Julian Chavarriaga, D. Jiang, D. Spratt, N. Fleshner, C. Wallis   +10 more
semanticscholar   +1 more source

Inositol trisphosphate and cyclic adenosine diphosphate-ribose increase quantal transmitter release at frog motor nerve terminals: possible involvement of smooth endoplasmic reticulum

Neuroscience, 1999
The release of chemical transmitter from nerve terminals is critically dependent on a transient increase in intracellular Ca2+.6,25 The increase in Ca2+ may be due to influx of Ca2+ from the extracellular fluid15 or release of Ca2+ from intracellular ...
E Brailoiu, Michael D Miyamoto
exaly   +2 more sources