Results 1 to 10 of about 70 (70)
Adenosine-Metabolizing Enzymes, Adenosine Kinase and Adenosine Deaminase, in Cancer [PDF]
Biomolecules, 2022 The immunosuppressive effect of adenosine in the microenvironment of a tumor is well established. Presently, researchers are developing approaches in immune therapy that target inhibition of adenosine or its signaling such as CD39 or CD73 inhibiting antibodies or adenosine A2A receptor antagonists.
Galina Zhulai +3 more
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Developmental Role of Adenosine Kinase in the Cerebellum [PDF]
eneuro, 2021 AbstractAdenosine acts as a neuromodulator and metabolic regulator of the brain through receptor dependent and independent mechanisms. In the brain, adenosine is tightly controlled through its metabolic enzyme adenosine kinase (ADK), which exists in a cytoplasmic (ADK-S) and nuclear (ADK-L) isoform.
Hoda Gebril +6 more
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Mycobacterial adenosine kinase is not a typical adenosine kinase [PDF]
FEBS Letters, 2009 Adenosine kinase (AK) is only found in eukaryotes. Recently, a Mycobacterium tuberculosis (MTub) protein exhibiting greater sequence similarity to ribokinases (RK) was identified as AK. We have expressed AKs from MTub, human and Chinese hamster (CH) cells in Escherichia coli and also AK from human and MTub in AK‐deficient CH cells. While both E.
Bhag Singh, Jae Park, Radhey S. Gupta
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The antiinflammatory effects of an adenosine kinase inhibitor are mediated by adenosine [PDF]
Arthritis & Rheumatism, 1995 AbstractObjective. The acute antiinflammatory effects of methotrexate are mediated, at least in part, by increased extracellular adenosine concentrations at inflamed sites. This observation suggests that other agents that increase extracellular adenosine concentrations might also reduce inflammation.
Dwight Naime +2 more
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Upregulation of Adenosine Kinase in Rasmussen Encephalitis [PDF]
Journal of Neuropathology & Experimental Neurology, 2013 Rasmussen encephalitis (RE) is a rare neurologic disorder of childhood characterized by unihemispheric inflammation, progressive neurologic deficits, and intractable focal epilepsy. The pathogenesis of RE is still enigmatic. Adenosine is a key endogenous signaling molecule with anticonvulsive and anti-inflammatory effects, and our previous work ...
Yuguang Guan +9 more
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Adenosine Dysfunction and Adenosine Kinase in Epileptogenesis [PDF]
The Open Neuroscience Journal, 2010 Traditionally, epilepsy has been considered to be a disorder of neuronal dysfunction. Based on this dogma, drug development efforts have largely focused on neurocentric model systems to screen for compounds that affect the function of neurons. Unfortunately, about 30% of all patients with epilepsy - or more than 20 million worldwide - are refractory to
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Adenosine Kinase Deficiency: Report and Review [PDF]
Neuropediatrics, 2018 AbstractAdenosine kinase (ADK) deficiency (OMIM [online mendelian inheritance in man]: 614300) is an autosomal recessive disorder of adenosine and methionine metabolism, with a unique clinical phenotype, mainly involving the central nervous system and dysmorphic features.
Alhusani, Alhanouf +4 more
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Properties of rat heart adenosine kinase [PDF]
Biochemical Journal, 1984 Adenosine kinase was purified 870-fold from rat heart by a combination of gel filtration and affinity chromatography. The preparation was free of purine-metabolizing enzymes that could interfere in the assay of the kinase. A study of the properties of the purified enzyme showed that it is activated by Na+ and K+, it possesses a broad pH optimum between
E A Newsholme, M N Fisher
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The adenosine kinase hypothesis of epileptogenesis [PDF]
Progress in Neurobiology, 2008 Current therapies for epilepsy are largely symptomatic and do not affect the underlying mechanisms of disease progression, i.e. epileptogenesis. Given the large percentage of pharmacoresistant chronic epilepsies, novel approaches are needed to understand and modify the underlying pathogenetic mechanisms.
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Working memory and the homeostatic control of brain adenosine by adenosine kinase [PDF]
Neuroscience, 2012 The neuromodulator adenosine maintains brain homeostasis and regulates complex behaviour via activation of inhibitory and excitatory adenosine receptors (ARs) in a brain region-specific manner. AR antagonists such as caffeine have been shown to ameliorate cognitive impairments in animal disease models but their effects on learning and memory in normal ...
Detlev Boison +5 more
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