Adenosine-Metabolizing Enzymes, Adenosine Kinase and Adenosine Deaminase, in Cancer [PDF]
Biomolecules, 2022 The immunosuppressive effect of adenosine in the microenvironment of a tumor is well established. Presently, researchers are developing approaches in immune therapy that target inhibition of adenosine or its signaling such as CD39 or CD73 inhibiting ...
Galina Zhulai +3 more
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Adenosine Kinase on Deoxyribonucleic Acid Methylation: Adenosine Receptor-Independent Pathway in Cancer Therapy [PDF]
Frontiers in Pharmacology, 2022 Methylation is an important mechanism contributing to cancer pathology. Methylation of tumor suppressor genes and oncogenes has been closely associated with tumor occurrence and development.
Hao-Yun Luo +5 more
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Case Report: Adenosine kinase deficiency diagnosed 10 years after liver transplantation: Novel phenotypic insights [PDF]
Frontiers in Pediatrics, 2022 Adenosine kinase (ADK) deficiency is a rare inborn error of methionine and adenosine metabolism. So far, a total of 27 patients with ADK deficiency have been reported.
Patryk Lipiński +7 more
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Adenosine kinase deficiency presenting with tortuous cervical arteries: A risk factor for recurrent stroke [PDF]
JIMD Reports, 2021 Adenosine kinase (ADK) deficiency is a very rare inborn error of methionine and adenosine metabolism. It is characterized by developmental delay, hypotonia, epilepsy, facial dysmorphism, failure to thrive, transient liver dysfunction with cholestasis ...
José A. Paz +9 more
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Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase. [PDF]
PLoS ONE, 2019 Cordycepin is an efficient component of Cordyceps spp, a traditional Chinese medicine widely used for healthcare in China, and has been recently acted as a strong anticancer agent for clinic.
Feng Huang +4 more
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Adenosine Kinase Inhibition Prevents Severe Acute Pancreatitis via Suppressing Inflammation and Acinar Cell Necroptosis [PDF]
Frontiers in Cell and Developmental Biology, 2022 Background: Inflammatory disorder and acinar cell death contribute to the initiation and progression of severe acute pancreatitis (SAP). Adenosine kinase (ADK) has potential effects on both inflammation and cell death.
Shukun Sun +32 more
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Corrigendum: Adenosine kinase on deoxyribonucleic acid methylation: Adenosine receptor-independent pathway in cancer therapy [PDF]
Frontiers in Pharmacology, 2023 Hao-Yun Luo +5 more
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Therapeutic potential of adenosine kinase inhibition-Revisited. [PDF]
Pharmacol Res Perspect, 2019 AbstractAdenosine (ADO) is an endogenous protective regulator that restores cellular energy balance in response to tissue trauma. Extracellular ADO has a half‐life of the order of seconds thus restricting its actions to tissues and cellular sites where it is released.
Jarvis MF.
europepmc +4 more sources
Metabolic Aspects of Adenosine Functions in the Brain
Frontiers in Pharmacology, 2021 Adenosine, acting both through G-protein coupled adenosine receptors and intracellularly, plays a complex role in multiple physiological and pathophysiological processes by modulating neuronal plasticity, astrocytic activity, learning and memory, motor ...
Mercedes Garcia-Gil +5 more
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Mycobacterial adenosine kinase is not a typical adenosine kinase [PDF]
FEBS Letters, 2009 Adenosine kinase (AK) is only found in eukaryotes. Recently, a Mycobacterium tuberculosis (MTub) protein exhibiting greater sequence similarity to ribokinases (RK) was identified as AK. We have expressed AKs from MTub, human and Chinese hamster (CH) cells in Escherichia coli and also AK from human and MTub in AK‐deficient CH cells. While both E.
Park, Jae, Singh, Bhag, Gupta, Radhey S.
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