Results 11 to 20 of about 165,863 (254)

Rapid Eye Movement Sleep Deprivation Combined With Fluoxetine Protects Against Depression-Induced Damage and Apoptosis in Rat Hippocampi via A1 Adenosine Receptor

Frontiers in Psychiatry, 2021
Background: Rapid eye movement sleep deprivation (REMSD) and fluoxetine affect depression, yet the detailed molecular mechanisms were not clear.Methods: Rat depression chronic unpredictable stress was constructed, and the body weight of rats was measured.
Xuan Ju, Shengdong Wang, Pan Yan, Chunyan Zhu, Xiwen Hu, Jiezheng Dong, Zhonglin Tan   +6 more
doaj   +1 more source

Adenosinergic depression of glutamatergic transmission in the entorhinal cortex of juvenile rats via reduction of glutamate release probability and the number of releasable vesicles. [PDF]

PLoS ONE, 2013
Adenosine is an inhibitory neuromodulator that exerts antiepileptic effects in the brain and the entorhinal cortex (EC) is an essential structure involved in temporal lobe epilepsy.
Shouping Wang, Lalitha Kurada, Nicholas I Cilz, Xiaotong Chen, Zhaoyang Xiao, Hailong Dong, Saobo Lei   +6 more
doaj   +1 more source

Metformin promotes angiogenesis and functional recovery in aged mice after spinal cord injury by adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway

Neural Regeneration Research, 2023
Treatment with metformin can lead to the recovery of pleiotropic biological activities after spinal cord injury. However, its effect on spinal cord injury in aged mice remains unclear.
Jin-Yun Zhao, Xiao-Long Sheng, Cheng-Jun Li, Tian Qin, Run-Dong He, Guo-Yu Dai, Yong Cao, Hong-Bin Lu, Chun-Yue Duan, Jian-Zhong Hu   +9 more
doaj   +1 more source

The antiinflammatory effects of an adenosine kinase inhibitor are mediated by adenosine [PDF]

Arthritis & Rheumatism, 1995
AbstractObjective. The acute antiinflammatory effects of methotrexate are mediated, at least in part, by increased extracellular adenosine concentrations at inflamed sites. This observation suggests that other agents that increase extracellular adenosine concentrations might also reduce inflammation.
B N, Cronstein, D, Naime, G, Firestein
openaire   +2 more sources

Calcineurin Contributes to the Enhancing Effect of Adenosine on Nerve Growth Factor-Induced Neurite Outgrowth via the Decreased Duration of p38 Mitogen-Activated Protein Kinase Phosphorylation

Journal of Pharmacological Sciences, 2004
Adenosine enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. We found that adenosine increases NGF-induced phosphorylation of extracellular signal-regulated kinase (ERK), but decreases the duration of phosphorylation of p38 ...
Yoshikage Muroi, Toshiaki Ishii, Kentarou Teramoto, Masatoshi Hori, Masakazu Nishimura   +4 more
doaj   +1 more source

Crystal structures of T. b. rhodesiense adenosine kinase complexed with inhibitor and activator: implications for catalysis and hyperactivation. [PDF]

PLoS Neglected Tropical Diseases, 2011
BACKGROUND: The essential purine salvage pathway of Trypanosoma brucei bears interesting catalytic enzymes for chemotherapeutic intervention of Human African Trypanosomiasis.
Sabine Kuettel, Jason Greenwald, Dirk Kostrewa, Shaheen Ahmed, Leonardo Scapozza, Remo Perozzo   +5 more
doaj   +1 more source

Cellular Uptake and Intracellular Phosphorylation of GS-441524: Implications for Its Effectiveness against COVID-19

Viruses, 2021
GS-441524 is an adenosine analog and the parent nucleoside of the prodrug remdesivir, which has received emergency approval for treatment of COVID-19. Recently, GS-441524 has been proposed to be effective in the treatment of COVID-19, perhaps even being ...
Henrik Berg Rasmussen, Gesche Jürgens, Ragnar Thomsen, Olivier Taboureau, Kornelius Zeth, Poul Erik Hansen, Peter Riis Hansen   +6 more
doaj   +1 more source

Adenosine Dysfunction and Adenosine Kinase in Epileptogenesis [PDF]

The Open Neuroscience Journal, 2010
Traditionally, epilepsy has been considered to be a disorder of neuronal dysfunction. Based on this dogma, drug development efforts have largely focused on neurocentric model systems to screen for compounds that affect the function of neurons. Unfortunately, about 30% of all patients with epilepsy - or more than 20 million worldwide - are refractory to
openaire   +2 more sources

The Good, the Bad, and the Deadly: Adenosinergic Mechanisms Underlying Sudden Unexpected Death in Epilepsy

Frontiers in Neuroscience, 2021
Adenosine is an inhibitory modulator of neuronal excitability. Neuronal activity results in increased adenosine release, thereby constraining excessive excitation.
Benton Purnell, Madhuvika Murugan, Raja Jani, Detlev Boison, Detlev Boison, Detlev Boison   +5 more
doaj   +1 more source

Adenosine stimulates the basolateral 50 pS K+ channel in renal proximal tubule via adenosine-A1 receptor

Frontiers in Physiology, 2023
Background: The basolateral potassium channels play an important role in maintaining the membrane transport in the renal proximal tubules (PT) and adenosine receptors have been shown to regulate the trans-epithelial Na+ absorption in the PT.
Hao Liu, Qi Sun, Zheng Ding, Wensen Shi, Wen-Hui Wang, Chengbiao Zhang   +5 more
doaj   +1 more source