Results 21 to 30 of about 745,257 (254)

Interaction of renin–angiotensin system and adenosine monophosphate–activated protein kinase signaling pathway in renal carcinogenesis of uninephrectomized rats

Tumor Biology, 2017
Renin–angiotensin system and adenosine monophosphate–activated protein kinase signaling pathway both play important roles in carcinogenesis, but the interplay of renin–angiotensin system and adenosine monophosphate–activated protein kinase in ...
Ke-Ke Yang, Yi Sui, Hui-Rong Zhou, Hai-Lu Zhao   +3 more
doaj   +1 more source

A depletable pool of adenosine in area CA1 of the rat hippocampus [PDF]

, 2001
Adenosine plays a major modulatory and neuroprotective role in the mammalian CNS. During cerebral metabolic stress, such as hypoxia or ischemia, the increase in extracellular adenosine inhibits excitatory synaptic transmission onto vulnerable neurons via
Darren Caldwell, Caldwell, Darren, Feruza Nuritova, Bruno G. Frenguelli, Dale, Nicholas, Pearson, Tim, Nuritova, Feruza, Frenguelli, Bruno G., Tim Pearson, Nicholas Dale   +9 more
core   +1 more source

Role of cGMP as second messenger of adenosine in the inhibition of renin release [PDF]

, 1988
Adenosine is known to be a potent inhibitor of renin release from the kidneys. The aim of this study was to investigate the transmembrane signalling avenue that the second messenger of adenosine causes inhibition of renal renin release.
Kurtz, Armin, Della Bruna, Roberto, Della Bruna, R., Bauer, Christian, Pfeilschifter, Josef, Pfeilschifter, J.   +5 more
core   +1 more source

Evidence for coordinated induction and repression of ecto-5'-nucleotidase (CD73) and the A2a adenosine receptor in a human B cell line [PDF]

, 2003
In the human B cell line P493-6 two mitogenic signals, the EpsteinBarr virus nuclear antigen 2 (EBNA2) and myc, can be independently regulated by means of an estrogen receptor fusion construct or an inducible expression vector, respectively.
Kempkes, B., W. Gutensohn, Napieralski, R., Gutensohn, W., R. Napieralski, B. Kempkes   +5 more
core   +1 more source

The dipeptidyl peptidase-IV inhibitor gemigliptin alone or in combination with NVP-AUY922 has a cytotoxic activity in thyroid carcinoma cells

Tumor Biology, 2017
The effect of the dipeptidyl peptidase-IV inhibitor gemigliptin alone or in combination with the heat shock protein 90 inhibitor NVP-AUY922 (AUY922) on survival of thyroid carcinoma cells was elucidated. The SW1736 and TPC-1 human thyroid carcinoma cells
Si Hyoung Kim, Jun Goo Kang, Chul Sik Kim, Sung-Hee Ihm, Moon Gi Choi, Hyung Joon Yoo, Seong Jin Lee   +6 more
doaj   +1 more source

The dynamics of single spike-evoked adenosine release in the cerebellum [PDF]

, 2011
The purine adenosine is a potent neuromodulator in the brain, with roles in a number of diverse physiological and pathological processes. Modulators such as adenosine are difficult to study as once released they have a diffuse action (which can affect ...
Boris P. Klyuch, Mark J. Wall, Richardson, Magnus J. E., Klyuch, Boris P., Dale, Nicholas, Magnus J. E. Richardson, Wall, Mark J., Nicholas Dale   +7 more
core   +1 more source

Nucleoside Transport Inhibition by Dipyridamole Prevents Angiogenesis Impairment by Homocysteine and Adenosine

Journal of Pharmacy & Pharmaceutical Sciences, 2015
Purpose: Adenosine plays an important role in the pathogenesis of homocysteine-associated vascular complications. Methods: This study examined the effects of dipyridamole, an inhibitor for nucleoside transport, on impaired angiogenic processes caused by ...
Antony Kam, Valentina Razmovski-Naumovski, Xian Zhou, John Troung, Kelvin Chan   +4 more
doaj   +1 more source

Wakefulness affects synaptic and network activity by increasing extracellular astrocyte-derived adenosine [PDF]

, 2012
Loss of sleep causes an increase in sleep drive and deficits in hippocampal-dependent memory. Both of these responses are thought to require activation of adenosine A1 receptors (adorA1Rs) and release of transmitter molecules including ATP, which is ...
Schmitt, L. Ian, R. E. Sims, Sims, Robert E., P. G. Haydon, Dale, Nicholas, Sims, Robert, Haydon, Philip G, L. I. Schmitt, N. Dale, Schmitt, L Ian   +9 more
core   +1 more source

Functional role of the polymorphic 647 T/C variant of ENT1 (SLC29A1) and its association with alcohol withdrawal seizures. [PDF]

, 2011
Adenosine is involved in several neurological and behavioral disorders including alcoholism. In cultured cell and animal studies, type 1 equilibrative nucleoside transporter (ENT1, slc29a1), which regulates adenosine levels, is known to regulate ethanol ...
Hyung Wook Nam, Karpyak Victor M., Preuss Ulrich W., Peter Zill, Colin Colby, David A. Mrazek, Colby Colin, Biernacka Joanna M., Moonnoh R. Lee, Preuss, Ulrich W., Victor M. Karpyak, Lee, Moonnoh R., Kim, Jeong-Hyun, Kim Jeong-Hyun, Lee Moonnoh R., Zill, Peter, Jeong-Hyun Kim, Joanna M. Biernacka, Nam Hyung Wook, David A Mrazek, Gihyun Yoon, Moonnoh R Lee, Ulrich W. Preuss, Zill Peter, Colby, Colin, Doo-Sup Choi, Yoon, Gihyun, Joanna M Biernacka, Ulrich W Preuss, Mrazek, David A., Nam, Hyung Wook, Yoon Gihyun, Choi, Doo-Sup, Victor M Karpyak, Mrazek David A., Biernacka, Joanna M., Choi Doo-Sup, Karpyak, Victor M.   +37 more
core   +2 more sources

Extracellular Degradation Into Adenosine and the Activities of Adenosine Kinase and AMPK Mediate Extracellular NAD+-Produced Increases in the Adenylate Pool of BV2 Microglia Under Basal Conditions

Frontiers in Cellular Neuroscience, 2018
Cumulating evidence has indicated NAD+ deficiency as a common central pathological factor of multiple diseases and aging. NAD+ supplement is highly protective in various disease and aging models, while two key questions have remained unanswered: (1) Does
Jie Zhang, Caixia Wang, Haibo Shi, Danhong Wu, Weihai Ying, Weihai Ying   +5 more
doaj   +1 more source