Results 21 to 30 of about 165,863 (254)
Presynaptic Purinergic Modulation of the Rat Neuro-Muscular Transmission
Current Issues in Molecular Biology, 2023 ATP, being a well-known universal high-energy compound, plays an important role as a signaling molecule and together with its metabolite adenosine they both attenuate the release of acetylcholine in the neuro-muscular synapse acting through membrane P2 ...
Adel E. Khairullin +2 more
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Adenosine deaminase and adenosine kinase in rat hepatomas and kidney tumours [PDF]
British Journal of Cancer, 1978 Adenosine deaminase and adenosine kinase have been measured in rat liver, 12 transplantable hepatomas, regenerating, foetal and neonatal liver, adult and neonatal rat kidney and 2 transplantable kidney tumours. Adenosine, deaminase activity, relative to the normal liver value, was elevated 2-4 fold in hepatomas of rapid growth rate, was in the normal ...
R C, Jackson, H P, Morris, G, Weber
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Tumor Biology, 2017 Renin–angiotensin system and adenosine monophosphate–activated protein kinase signaling pathway both play important roles in carcinogenesis, but the interplay of renin–angiotensin system and adenosine monophosphate–activated protein kinase in ...
Ke-Ke Yang +3 more
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Working memory and the homeostatic control of brain adenosine by adenosine kinase [PDF]
Neuroscience, 2012 The neuromodulator adenosine maintains brain homeostasis and regulates complex behaviour via activation of inhibitory and excitatory adenosine receptors (ARs) in a brain region-specific manner. AR antagonists such as caffeine have been shown to ameliorate cognitive impairments in animal disease models but their effects on learning and memory in normal ...
P, Singer +4 more
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Adenosine Kinase Deficiency: Report and Review [PDF]
Neuropediatrics, 2018 AbstractAdenosine kinase (ADK) deficiency (OMIM [online mendelian inheritance in man]: 614300) is an autosomal recessive disorder of adenosine and methionine metabolism, with a unique clinical phenotype, mainly involving the central nervous system and dysmorphic features.
Alhanouf, Alhusani +4 more
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Tumor Biology, 2017 The effect of the dipeptidyl peptidase-IV inhibitor gemigliptin alone or in combination with the heat shock protein 90 inhibitor NVP-AUY922 (AUY922) on survival of thyroid carcinoma cells was elucidated. The SW1736 and TPC-1 human thyroid carcinoma cells
Si Hyoung Kim +6 more
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The adenosine kinase hypothesis of epileptogenesis [PDF]
Progress in Neurobiology, 2008 Current therapies for epilepsy are largely symptomatic and do not affect the underlying mechanisms of disease progression, i.e. epileptogenesis. Given the large percentage of pharmacoresistant chronic epilepsies, novel approaches are needed to understand and modify the underlying pathogenetic mechanisms.
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Properties of rat heart adenosine kinase [PDF]
Biochemical Journal, 1984 Adenosine kinase was purified 870-fold from rat heart by a combination of gel filtration and affinity chromatography. The preparation was free of purine-metabolizing enzymes that could interfere in the assay of the kinase. A study of the properties of the purified enzyme showed that it is activated by Na+ and K+, it possesses a broad pH optimum between
M N, Fisher, E A, Newsholme
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Journal of Pharmacy & Pharmaceutical Sciences, 2015 Purpose: Adenosine plays an important role in the pathogenesis of homocysteine-associated vascular complications. Methods: This study examined the effects of dipyridamole, an inhibitor for nucleoside transport, on impaired angiogenic processes caused by ...
Antony Kam +4 more
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In vitro biosynthesis of ATP from adenosine and polyphosphate
Bioresources and Bioprocessing, 2021 Adenosine triphosphate (ATP) acts as a crucial energy currency in vivo, and it is a widely used energy and/or phosphate donor for enzyme-catalyzed reactions in vitro.
Chuanqi Sun +4 more
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