Adenosine-Metabolizing Enzymes, Adenosine Kinase and Adenosine Deaminase, in Cancer [PDF]
Biomolecules, 2022 The immunosuppressive effect of adenosine in the microenvironment of a tumor is well established. Presently, researchers are developing approaches in immune therapy that target inhibition of adenosine or its signaling such as CD39 or CD73 inhibiting ...
Galina Zhulai +3 more
doaj +3 more sources
Adenosine Kinase on Deoxyribonucleic Acid Methylation: Adenosine Receptor-Independent Pathway in Cancer Therapy [PDF]
Frontiers in Pharmacology, 2022 Methylation is an important mechanism contributing to cancer pathology. Methylation of tumor suppressor genes and oncogenes has been closely associated with tumor occurrence and development.
Hao-Yun Luo +5 more
doaj +2 more sources
Case Report: Adenosine kinase deficiency diagnosed 10 years after liver transplantation: Novel phenotypic insights [PDF]
Frontiers in Pediatrics, 2022 Adenosine kinase (ADK) deficiency is a rare inborn error of methionine and adenosine metabolism. So far, a total of 27 patients with ADK deficiency have been reported.
Patryk Lipiński +7 more
doaj +2 more sources
Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase. [PDF]
PLoS ONE, 2019 Cordycepin is an efficient component of Cordyceps spp, a traditional Chinese medicine widely used for healthcare in China, and has been recently acted as a strong anticancer agent for clinic.
Feng Huang +4 more
doaj +2 more sources
Adenosine kinase deficiency presenting with tortuous cervical arteries: A risk factor for recurrent stroke [PDF]
JIMD Reports, 2021 Adenosine kinase (ADK) deficiency is a very rare inborn error of methionine and adenosine metabolism. It is characterized by developmental delay, hypotonia, epilepsy, facial dysmorphism, failure to thrive, transient liver dysfunction with cholestasis ...
José A. Paz +9 more
doaj +2 more sources
Corrigendum: Adenosine kinase on deoxyribonucleic acid methylation: Adenosine receptor-independent pathway in cancer therapy [PDF]
Frontiers in Pharmacology, 2023 Hao-Yun Luo +5 more
doaj +2 more sources
Adenosine kinase: An epigenetic modulator in development and disease [PDF]
Neurochemistry International, 2021 Hoda M. Gebril +2 more
exaly +2 more sources
Metabolic Aspects of Adenosine Functions in the Brain
Frontiers in Pharmacology, 2021 Adenosine, acting both through G-protein coupled adenosine receptors and intracellularly, plays a complex role in multiple physiological and pathophysiological processes by modulating neuronal plasticity, astrocytic activity, learning and memory, motor ...
Mercedes Garcia-Gil +5 more
doaj +1 more source
Frontiers in Psychiatry, 2021 Background: Rapid eye movement sleep deprivation (REMSD) and fluoxetine affect depression, yet the detailed molecular mechanisms were not clear.Methods: Rat depression chronic unpredictable stress was constructed, and the body weight of rats was measured.
Xuan Ju +6 more
doaj +1 more source
Adenosinergic depression of glutamatergic transmission in the entorhinal cortex of juvenile rats via reduction of glutamate release probability and the number of releasable vesicles. [PDF]
PLoS ONE, 2013 Adenosine is an inhibitory neuromodulator that exerts antiepileptic effects in the brain and the entorhinal cortex (EC) is an essential structure involved in temporal lobe epilepsy.
Shouping Wang +6 more
doaj +1 more source