3',5'-Cyclic Adenosine Monophosphate- and Ca2+-Calmodulin-Dependent Endogenous Protein Phosphorylation Activity in Membranes of the Bovine Chromaffin Secretory Vesicles: Identification of Two Phosphorylated Components as Tyrosine Hydroxylase and Protein Kinase Regulatory Subunit Type II [PDF]
, 1983 : Membranes of the secretory vesicles from bovine adrenal medulla were investigated for the presence of the endogenous protein phosphorylation activity. Seven phosphoprotein bands in the molecular weight range of 250,000 to 30,000 were observed by means ...
Weber, W., Treiman, M., Gratzl, Manfred
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Cobra neurotoxin produces central analgesic and hyperalgesic actions via adenosine A and A receptors
Molecular Pain, 2017 Cobra neurotoxin, a short-chain peptide isolated from snake venom of Naja naja atra , showed both a central analgesic effect and a hyperalgesic effect in mice tests.
Chuang Zhao +3 more
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Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities
Frontiers in Pharmacology, 2020 The outbreak of the novel coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) requires urgent clinical interventions.
Jonathan D. Geiger +4 more
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BiomoleculesAdenosine has emerged as a central metabolic signal linking cellular stress to systemic physiological adaptation. Under conditions such as hypoxia, ischemia, inflammation, and tissue injury, extracellular adenosine triphosphate (eATP) released from ...
Shakta Mani Satyam +13 more
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In vitro biosynthesis of ATP from adenosine and polyphosphate
Bioresources and Bioprocessing, 2021 Adenosine triphosphate (ATP) acts as a crucial energy currency in vivo, and it is a widely used energy and/or phosphate donor for enzyme-catalyzed reactions in vitro.
Chuanqi Sun +4 more
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Adenosine-mediated modulation of ventral horn interneurons and spinal motoneurons in neonatal mice [PDF]
, 2015 The authors are grateful for support from the Wellcome Trust.Neuromodulation allows neural networks to adapt to varying environmental and biomechanical demands. Purinergic signalling is known to be an important modulatory system in many parts of the CNS,
Witts, Emily Charlotte +2 more
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BiomoleculesEpilepsy is a neurological disorder characterized by a long-lasting predisposition to recurrently generate unprovoked seizures. Epilepsy affects over 70 million people worldwide, with approximately one-third suffering from pharmacoresistant seizures ...
Xiaoning Zhao +3 more
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Effect of diabetes/hyperglycemia on the rat retinal adenosinergic system. [PDF]
PLoS ONE, 2013 The early stages of diabetic retinopathy (DR) are characterized by alterations similar to neurodegenerative and inflammatory conditions such as increased neural apoptosis, microglial cell activation and amplified production of pro-inflammatory cytokines.
Joana Vindeirinho +4 more
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Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
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Biosensor measurement of purine release from cerebellar cultures and slices [PDF]
, 2010 We have previously described an action-potential and Ca2+-dependent form of adenosine release in the molecular layer of cerebellar slices. The most likely source of the adenosine is the parallel fibres, the axons of granule cells. Using microelectrode
Eason, Robert +5 more
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