Results 31 to 40 of about 165,863 (254)

Extracellular Degradation Into Adenosine and the Activities of Adenosine Kinase and AMPK Mediate Extracellular NAD+-Produced Increases in the Adenylate Pool of BV2 Microglia Under Basal Conditions

Frontiers in Cellular Neuroscience, 2018
Cumulating evidence has indicated NAD+ deficiency as a common central pathological factor of multiple diseases and aging. NAD+ supplement is highly protective in various disease and aging models, while two key questions have remained unanswered: (1) Does
Jie Zhang, Caixia Wang, Haibo Shi, Danhong Wu, Weihai Ying, Weihai Ying   +5 more
doaj   +1 more source

Effect of diabetes/hyperglycemia on the rat retinal adenosinergic system. [PDF]

PLoS ONE, 2013
The early stages of diabetic retinopathy (DR) are characterized by alterations similar to neurodegenerative and inflammatory conditions such as increased neural apoptosis, microglial cell activation and amplified production of pro-inflammatory cytokines.
Joana Vindeirinho, Gabriel N Costa, Mariana B Correia, Cláudia Cavadas, Paulo F Santos   +4 more
doaj   +1 more source

Upregulation of Adenosine Kinase in Rasmussen Encephalitis [PDF]

Journal of Neuropathology & Experimental Neurology, 2013
Rasmussen encephalitis (RE) is a rare neurologic disorder of childhood characterized by unihemispheric inflammation, progressive neurologic deficits, and intractable focal epilepsy. The pathogenesis of RE is still enigmatic. Adenosine is a key endogenous signaling molecule with anticonvulsive and anti-inflammatory effects, and our previous work ...
Luan, Guoming, Gao, Qing, Guan, Yuguang, Zhai, Feng, Zhou, Jian, Liu, Changqing, Chen, Yin, Yao, Kun, Qi, Xueling, Li, Tianfu   +9 more
openaire   +2 more sources

Cobra neurotoxin produces central analgesic and hyperalgesic actions via adenosine A and A receptors

Molecular Pain, 2017
Cobra neurotoxin, a short-chain peptide isolated from snake venom of Naja naja atra , showed both a central analgesic effect and a hyperalgesic effect in mice tests.
Chuang Zhao, Jun Zhao, Qian Yang, Yong Ye   +3 more
doaj   +1 more source

Adenosine Signaling as a Central Integrative Network in Cellular Stress Responses and a Therapeutically Actionable Target in Human Disease

Biomolecules
Adenosine has emerged as a central metabolic signal linking cellular stress to systemic physiological adaptation. Under conditions such as hypoxia, ischemia, inflammation, and tissue injury, extracellular adenosine triphosphate (eATP) released from ...
Shakta Mani Satyam, Mohamed El-Tanani, Wasim Iyad Alghoul, Malak Moones Abedi, Shabil Fathah Farook, Ibrahim Khalil Alabid, Mohammed Dalbah, Natasha Nasser, Samreen Fazal, Mariam Radhi Al-Talqani, Mohammed Mahmood Ali, Ebrahim Safaii, Wed Burhan Jameel Al-Shammari, Burhanuddin Murtaza Patanwala   +13 more
doaj   +1 more source

Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities

Frontiers in Pharmacology, 2020
The outbreak of the novel coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) requires urgent clinical interventions.
Jonathan D. Geiger, Nabab Khan, Madhuvika Murugan, Detlev Boison, Detlev Boison   +4 more
doaj   +1 more source

Increases in Interstitial Adenosine and Cerebral Blood Flow with Inhibition of Adenosine Kinase and Adenosine Deaminase [PDF]

Journal of Cerebral Blood Flow & Metabolism, 1993
The purpose of this study was to determine the changes in interstitial fluid (ISF) adenosine and cerebral blood flow (CBF) during inhibition of adenosine kinase or adenosine deaminase. Brain microdialysis was used to (a) measure CBF (H 2 clearance), (b) sample cerebral ISF, and (c) deliver ...
V M, Sciotti, D G, Van Wylen
openaire   +2 more sources

Therapeutic Potential Target of Adenosine for Epilepsy: Focusing on Its Interaction with the Molecular Epileptogenic Network

Biomolecules
Epilepsy is a neurological disorder characterized by a long-lasting predisposition to recurrently generate unprovoked seizures. Epilepsy affects over 70 million people worldwide, with approximately one-third suffering from pharmacoresistant seizures ...
Xiaoning Zhao, Jiahui Deng, Zhonghua Xiong, Tianfu Li   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source