Results 51 to 60 of about 165,863 (254)

Phosphorylation of adenosine in anoxic hepatocytes by an exchange reaction catalysed by adenosine kinase [PDF]

Biochemical Journal, 1993
The elevation of adenosine levels induced by anoxia in isolated rat hepatocytes has been shown to result mainly from an arrest of the recycling of the nucleoside by adenosine kinase [Bontemps, Vincent and Van den Berghe (1993) Biochem. J. 290, 671-677].
F, Bontemps, M, Mimouni, G, Van den Berghe   +2 more
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The impact of and changes in the oxidative status in the post-injury period following nonpenetrating traumatic brain injuries

Journal of International Medical Research
Objective In the pathogenesis of the post-injury period following nonpenetrating traumatic brain injuries (TBIs; post-TBIs), pathological metabolic changes in the oxidative status are important, as a complete understanding of their interactions can ...
Yevgeniya Lekomtseva, Andrey Belousov, Tkachenko Vitaliy   +2 more
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

SAM transmethylation pathway and adenosine recycling to ATP are essential for systemic regulation and immune response

eLife
During parasitoid wasp infection, activated immune cells of Drosophila melanogaster larvae release adenosine to conserve nutrients for immune response.
Pavla Nedbalová, Nikola Kaislerova, Lenka Chodakova, Martin Moos, Tomáš Doležal   +4 more
doaj   +1 more source

Adenosine A2A-Receptor Stimulation Inhibits Lipopolysaccharide-Induced Interleukin-18 Production in Monocytes

Journal of Pharmacological Sciences, 2007
Adenosine inhibited interleukin (IL)-18 production in lipopolysaccharide (LPS)-stimulated monocytes. The action of adenosine was antagonized by an adenosine A2A-receptor (A2AR) antagonist and was mimicked by an A2AR agonist, suggesting that the ...
Hideo Kohka Takahashi, Toru Kanke, Keyue Liu, Tadashi Yoshino, Toshiaki Sendo, Noriaki Tanaka, Masahiro Nishibori   +6 more
doaj   +1 more source

Homeostatic Control of Synaptic Activity by Endogenous Adenosine is Mediated by Adenosine Kinase [PDF]

Cerebral Cortex, 2012
Extracellular adenosine, a key regulator of neuronal excitability, is metabolized by astrocyte-based enzyme adenosine kinase (ADK). We hypothesized that ADK might be an upstream regulator of adenosine-based homeostatic brain functions by simultaneously affecting several downstream pathways.
M. j. Diogenes, R. Neves Tome, FUCILE, Sergio, K. Martinello, SCIANNI, MARIA, P. Theofilas, J. Lopatar, J. a. Ribeiro, MAGGI, Laura, B. g. Frenguelli, LIMATOLA, Cristina, D. Boison, A. m. Sebastiao   +12 more
openaire   +3 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A complex containing SNF1-related kinase (SnRK1) and adenosine kinase in Arabidopsis.

PLoS ONE, 2014
SNF1-related kinase (SnRK1) in plants belongs to a conserved family that includes sucrose non-fermenting 1 kinase (SNF1) in yeast and AMP-activated protein kinase (AMPK) in animals.
Gireesha Mohannath, Jamie N Jackel, Youn Hyung Lee, R Cody Buchmann, Hui Wang, Veena Patil, Allie K Adams, David M Bisaro   +7 more
doaj   +1 more source