Results 11 to 20 of about 70 (70)
Homeostatic Control of Synaptic Activity by Endogenous Adenosine is Mediated by Adenosine Kinase [PDF]
Cerebral Cortex, 2012 Extracellular adenosine, a key regulator of neuronal excitability, is metabolized by astrocyte-based enzyme adenosine kinase (ADK). We hypothesized that ADK might be an upstream regulator of adenosine-based homeostatic brain functions by simultaneously affecting several downstream pathways.
M. j. Diogenes +12 more
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Adenosine deaminase and adenosine kinase in rat hepatomas and kidney tumours [PDF]
British Journal of Cancer, 1978 Adenosine deaminase and adenosine kinase have been measured in rat liver, 12 transplantable hepatomas, regenerating, foetal and neonatal liver, adult and neonatal rat kidney and 2 transplantable kidney tumours. Adenosine, deaminase activity, relative to the normal liver value, was elevated 2-4 fold in hepatomas of rapid growth rate, was in the normal ...
George Weber +2 more
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Increases in Interstitial Adenosine and Cerebral Blood Flow with Inhibition of Adenosine Kinase and Adenosine Deaminase [PDF]
Journal of Cerebral Blood Flow & Metabolism, 1993 The purpose of this study was to determine the changes in interstitial fluid (ISF) adenosine and cerebral blood flow (CBF) during inhibition of adenosine kinase or adenosine deaminase. Brain microdialysis was used to (a) measure CBF (H2 clearance), (b) sample cerebral ISF, and (c) deliver drugs locally to the brain. Microdialysis probes were implanted
David G. L. Van Wylen +1 more
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Adenosine Kinase: Exploitation for Therapeutic Gain [PDF]
Pharmacological Reviews, 2013 Adenosine kinase (ADK; EC 2.7.1.20) is an evolutionarily conserved phosphotransferase that converts the purine ribonucleoside adenosine into 5'-adenosine-monophosphate. This enzymatic reaction plays a fundamental role in determining the tone of adenosine, which fulfills essential functions as a homeostatic and metabolic regulator in all living systems.
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A putative adenosine kinase family protein possesses adenosine diphosphatase activity [PDF]
Bioscience, Biotechnology, and Biochemistry, 2016 Abstract Adenosine kinase is a potential target for development of new types of drugs. The COG1839 family has been defined as “adenosine-specific kinase” family based on structural analysis and the adenosine-binding ability of a family member, PAE2307. However, there has been no experimental evidence with regard to the enzymatic function
Ryoji Masui +5 more
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Adenosine Kinase Mediates High Affinity Adenosine Salvage in Trypanosoma brucei [PDF]
Journal of Biological Chemistry, 2008 African sleeping sickness is caused by Trypanosoma brucei. This extracellular parasite lacks de novo purine biosynthesis, and it is therefore dependent on exogenous purines such as adenosine that is taken up from the blood and other body fluids by high affinity transporters. The general belief is that adenosine needs to be cleaved to adenine inside the
Pascal Mäser +5 more
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Adenosine kinase regulation of cardiomyocyte hypertrophy
American Journal of Physiology-Heart and Circulatory Physiology, 2011 There is evidence that extracellular adenosine can attenuate cardiac hypertrophy, but the mechanism by which this occurs is not clear. Here we investigated the role of adenosine receptors and adenosine metabolism in attenuation of cardiomyocyte hypertrophy.
Zhongbing Lu +6 more
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Phosphorylation of adenosine in anoxic hepatocytes by an exchange reaction catalysed by adenosine kinase [PDF]
Biochemical Journal, 1993 The elevation of adenosine levels induced by anoxia in isolated rat hepatocytes has been shown to result mainly from an arrest of the recycling of the nucleoside by adenosine kinase [Bontemps, Vincent and Van den Berghe (1993) Biochem. J. 290, 671-677].
G Van den Berghe +2 more
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Dysregulation of adenosine kinase isoforms in breast cancer [PDF]
Oncotarget, 2019 Dysregulated adenosine signaling pathway has been evidenced in the pathogenesis of breast cancer. However, the role of adenosine kinase (ADK) in tumorigenesis remains unclear while it crucially regulates the removal and availability of adenosine. ADK has two isoforms that localize to discrete subcellular spaces: i.e., nuclear, long-isoform (ADK-L) and ...
Hai-Ying Shen +6 more
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Adenosine‐AMP exchange activity is an integral part of the mammalian adenosine kinase [PDF]
IUBMB Life, 1996 AbstractPurified adenosine kinase (AK) from Syrian hamster and bovine liver was examined for the presence of adenosine (Ad)‐AMP exchange activity. The enzyme from both sources, in addition to catalyzing the conventional ATP‐dependent phosphorylation of adenosine, supported an Ad‐AMP exchange reaction that required ADP.
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