Results 11 to 20 of about 296,423 (346)
A putative adenosine kinase family protein possesses adenosine diphosphatase activity [PDF]
Bioscience, Biotechnology, and Biochemistry, 2016 Abstract Adenosine kinase is a potential target for development of new types of drugs. The COG1839 family has been defined as “adenosine-specific kinase” family based on structural analysis and the adenosine-binding ability of a family member, PAE2307. However, there has been no experimental evidence with regard to the enzymatic function
Fumiaki Tomoike +5 more
openalex +3 more sources
Metabolic Aspects of Adenosine Functions in the Brain
Frontiers in Pharmacology, 2021 Adenosine, acting both through G-protein coupled adenosine receptors and intracellularly, plays a complex role in multiple physiological and pathophysiological processes by modulating neuronal plasticity, astrocytic activity, learning and memory, motor ...
Mercedes Garcia-Gil +5 more
doaj +1 more source
Frontiers in Psychiatry, 2021 Background: Rapid eye movement sleep deprivation (REMSD) and fluoxetine affect depression, yet the detailed molecular mechanisms were not clear.Methods: Rat depression chronic unpredictable stress was constructed, and the body weight of rats was measured.
Xuan Ju +6 more
doaj +1 more source
Mycobacterial adenosine kinase is not a typical adenosine kinase [PDF]
FEBS Letters, 2009 Adenosine kinase (AK) is only found in eukaryotes. Recently, a Mycobacterium tuberculosis (MTub) protein exhibiting greater sequence similarity to ribokinases (RK) was identified as AK. We have expressed AKs from MTub, human and Chinese hamster (CH) cells in Escherichia coli and also AK from human and MTub in AK‐deficient CH cells. While both E.
Park, Jae, Singh, Bhag, Gupta, Radhey S.
openaire +2 more sources
Adenosinergic depression of glutamatergic transmission in the entorhinal cortex of juvenile rats via reduction of glutamate release probability and the number of releasable vesicles. [PDF]
PLoS ONE, 2013 Adenosine is an inhibitory neuromodulator that exerts antiepileptic effects in the brain and the entorhinal cortex (EC) is an essential structure involved in temporal lobe epilepsy.
Shouping Wang +6 more
doaj +1 more source
Neural Regeneration Research, 2023 Treatment with metformin can lead to the recovery of pleiotropic biological activities after spinal cord injury. However, its effect on spinal cord injury in aged mice remains unclear.
Jin-Yun Zhao +9 more
doaj +1 more source
Crystal structures of T. b. rhodesiense adenosine kinase complexed with inhibitor and activator: implications for catalysis and hyperactivation. [PDF]
PLoS Neglected Tropical Diseases, 2011 BACKGROUND: The essential purine salvage pathway of Trypanosoma brucei bears interesting catalytic enzymes for chemotherapeutic intervention of Human African Trypanosomiasis.
Sabine Kuettel +5 more
doaj +1 more source
Viruses, 2021 GS-441524 is an adenosine analog and the parent nucleoside of the prodrug remdesivir, which has received emergency approval for treatment of COVID-19. Recently, GS-441524 has been proposed to be effective in the treatment of COVID-19, perhaps even being ...
Henrik Berg Rasmussen +6 more
doaj +1 more source
Frontiers in Physiology, 2023 Background: The basolateral potassium channels play an important role in maintaining the membrane transport in the renal proximal tubules (PT) and adenosine receptors have been shown to regulate the trans-epithelial Na+ absorption in the PT.
Hao Liu +5 more
doaj +1 more source
Frontiers in Neuroscience, 2021 Adenosine is an inhibitory modulator of neuronal excitability. Neuronal activity results in increased adenosine release, thereby constraining excessive excitation.
Benton Purnell +5 more
doaj +1 more source