Results 21 to 30 of about 70 (70)
Affinity labeling of pyridoxal kinase with adenosine polyphosphopyridoxal.
Journal of Biological Chemistry, 1988 Pyridoxal kinase is inactivated by preincubation with the affinity label reagent adenosine tetraphosphate pyridoxal (AP4-PL) at a mixing molar ratio of 5:1 AP4-PL contains structural features of the substrates pyridoxal and ATP. The substrate ATP affords substantial protection against inactivation.
DOMINICI, Paola +3 more
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Therapeutic potential of adenosine kinase inhibition—Revisited [PDF]
Pharmacology Research & Perspectives, 2019 AbstractAdenosine (ADO) is an endogenous protective regulator that restores cellular energy balance in response to tissue trauma. Extracellular ADO has a half‐life of the order of seconds thus restricting its actions to tissues and cellular sites where it is released.
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The role of adenosine kinase in regulating adenosine concentration [PDF]
Biochemical Journal, 1985 openaire +3 more sources
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ChemInform Abstract: Adenosine Kinase Inhibitors
ChemInform, 1998AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Shripad S. Bhagwat +2 more
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Regulation of adenosine kinase by adenosine analogs.
Molecular Pharmacology, 1988The regulation of adenosine phosphorylation by adenosine analogs was studied using highly purified human placental adenosine kinase [ATP: adenosine 5'-phosphotransferase (EC 2.7.1.20)]. Our observations lead us to classify the analogs into three groups as follows: type I, 5'-N-ethylcarboxamidoadenosine and 5'-methylthioadenosine; type II, N6 ...
B B, Lin, M C, Hurley, I H, Fox
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On the Modification of Adenosine Kinase by Thiols
Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 1978The catalytic activity of adenosine kinase (EC 2.7.1.20) from yeast is very labile. Even incubation with thiols provokes a loss of two thirds of its enzymatic activity. Concomitantly, two SH-groups appear on the enzyme in addition to the single SH-group already present in the untreated enzyme, the latter being absolutely essential for activity ...
Guido R. Hartmann, Tillmann J. Neudecker
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Nonnucleoside Inhibitors of Adenosine Kinase
Current Pharmaceutical Design, 2004Adenosine (ADO) is an endogenous inhibitory neuromodulator that increases nociceptive thresholds in response to tissue trauma and inflammation. Adenosine kinase (AK) is a key intracellular enzyme regulating intra- and extracellular concentrations of ADO.
Chih-Hung Lee, Arthur Gomtsyan
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Adenosine kinase from Cryptosporidium parvum
Molecular and Biochemical Parasitology, 2006Analysis of the Cryptosporidium parvum genome demonstrates that the parasite cannot synthesize purines de novo and reveals that the sole route for purine salvage by the parasite is via adenosine kinase (CpAK). In order to initiate a biochemical characterization of CpAK and ultimately validate this apparently essential enzyme as a therapeutic target ...
Boris Striepen +2 more
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Adenosine kinase from human liver
Biochimica et Biophysica Acta (BBA) - Enzymology, 1981Adenosine kinase (ATP: adenosine 5'-phosphotransferase, EC 2.7.1.20) has been purified to homogeneity from human liver. The yield was 55% of the initial activity with a final specific activity of 6.3 mumol/min per mg protein. The molecular weight was estimated as about 40 000 by Sephadex G-100 gel filtration and polyacrylamide gel electrophoresis in ...
Nobuaki Ogasawara +2 more
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Adenosine Metabolism, Adenosine Kinase, and Evolution
2012The enzyme adenosine kinase (AdK, ADK, or AK) plays an important role in regulating the intracellular as well as extracellular concentrations of adenosine and hence its diverse physiological actions. In view of the enormous pharmacological potential of adenosine, there has been much interest in studying adenosine kinase over the past few decades.
Jaoek Park, Radhey S. Gupta
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