Results 31 to 40 of about 290,534 (304)
Adenosine Kinase Deficiency: Report and Review [PDF]
Neuropediatrics, 2018 AbstractAdenosine kinase (ADK) deficiency (OMIM [online mendelian inheritance in man]: 614300) is an autosomal recessive disorder of adenosine and methionine metabolism, with a unique clinical phenotype, mainly involving the central nervous system and dysmorphic features.
Alhusani, Alhanouf +4 more
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Evidence for coordinated induction and repression of ecto-5'-nucleotidase (CD73) and the A2a adenosine receptor in a human B cell line [PDF]
, 2003 In the human B cell line P493-6 two mitogenic signals, the EpsteinBarr virus nuclear antigen 2 (EBNA2) and myc, can be independently regulated by means of an estrogen receptor fusion construct or an inducible expression vector, respectively.
Burgemeister R. +6 more
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Properties of rat heart adenosine kinase [PDF]
Biochemical Journal, 1984 Adenosine kinase was purified 870-fold from rat heart by a combination of gel filtration and affinity chromatography. The preparation was free of purine-metabolizing enzymes that could interfere in the assay of the kinase. A study of the properties of the purified enzyme showed that it is activated by Na+ and K+, it possesses a broad pH optimum between
M N, Fisher, E A, Newsholme
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Frontiers in Cellular Neuroscience, 2018 Cumulating evidence has indicated NAD+ deficiency as a common central pathological factor of multiple diseases and aging. NAD+ supplement is highly protective in various disease and aging models, while two key questions have remained unanswered: (1) Does
Jie Zhang +5 more
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Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities
Frontiers in Pharmacology, 2020 The outbreak of the novel coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) requires urgent clinical interventions.
Jonathan D. Geiger +4 more
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Upregulation of inducible NO synthase by exogenous adenosine in vascular smooth muscle cells activated by inflammatory stimuli in experimental diabetes [PDF]
, 2016 BACKGROUND: Adenosine has been shown to induce nitric oxide (NO) production via inducible NO synthase (iNOS) activation in vascular smooth muscle cells (VSMCs). Although this is interpreted as a beneficial vasodilating pathway in vaso-occlusive disorders,
Cignarella, Andrea +4 more
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A putative adenosine kinase family protein possesses adenosine diphosphatase activity [PDF]
Bioscience, Biotechnology, and Biochemistry, 2016 Abstract Adenosine kinase is a potential target for development of new types of drugs. The COG1839 family has been defined as “adenosine-specific kinase” family based on structural analysis and the adenosine-binding ability of a family member, PAE2307. However, there has been no experimental evidence with regard to the enzymatic function
Fumiaki, Tomoike +5 more
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In vitro biosynthesis of ATP from adenosine and polyphosphate
Bioresources and Bioprocessing, 2021 Adenosine triphosphate (ATP) acts as a crucial energy currency in vivo, and it is a widely used energy and/or phosphate donor for enzyme-catalyzed reactions in vitro.
Chuanqi Sun +4 more
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Adenosine Kinase Mediates High Affinity Adenosine Salvage in Trypanosoma brucei [PDF]
Journal of Biological Chemistry, 2008 African sleeping sickness is caused by Trypanosoma brucei. This extracellular parasite lacks de novo purine biosynthesis, and it is therefore dependent on exogenous purines such as adenosine that is taken up from the blood and other body fluids by high affinity transporters. The general belief is that adenosine needs to be cleaved to adenine inside the
Munender, Vodnala +5 more
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Effect of diabetes/hyperglycemia on the rat retinal adenosinergic system. [PDF]
PLoS ONE, 2013 The early stages of diabetic retinopathy (DR) are characterized by alterations similar to neurodegenerative and inflammatory conditions such as increased neural apoptosis, microglial cell activation and amplified production of pro-inflammatory cytokines.
Joana Vindeirinho +4 more
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