Results 31 to 40 of about 70 (70)
Some of the next articles are maybe not open access.
Erythrocyte adenosine kinase activity in gout
Clinica Chimica Acta, 1976Erythrocyte adenosine kinase (AK) (EC 2.7.1.20) and guanosine monophosphate (GMP) reductase (EC 1.6.6.8) were measured in healthy male controls and primary gout subjects. Adenosine kinase activity in 19 controls and 26 gouty subjects was 0.717 +/- 0.176 and 0.615 +/- 0.128 nmol/mg protein/h, respectively. The difference was statistically significant (p
Nishida Yutaro +2 more
openaire +3 more sources
[23] Adenosine derivatives for dehydrogenases and kinases
1977Publisher Summary Among the coenzymes and regulatory compounds involved in biochemical reactions, adenine nucleotides are present in a large proportion of cases. Adenosine triphosphate and the corresponding diphosphate are required for many kinase reactions, in which a phosphoryl group is transferred to a variety of substrates; and adenosine is part ...
Roberta F. Colman +2 more
openaire +3 more sources
Therapeutic potential of adenosine kinase inhibitors
Expert Opinion on Investigational Drugs, 2000Adenosine kinase (AK; EC 2.7.1.20) is a key intracellular enzyme regulating intra and extracellular concentrations of adenosine (ADO), an endogenous modulator of intercellular signalling that reduces cell excitability during tissue stress and trauma. The inhibitory effects of ADO are mediated by interactions with specific cell-surface G-protein coupled
Elizabeth A. Kowaluk, Michael F. Jarvis
openaire +3 more sources
Isolation and Immunological Properties of Adenosine Kinase
Preparative Biochemistry, 1989Bovine liver adenosine kinase is a 43 kDa protein that catalyzes the transfer of phosphate from GTP or ATP to adenosine. Its immunological properties were compared to other GTP-binding proteins of approximately 40 kDa, in particular those involved in signal transduction, such as Gs and Gi, the stimulatory and inhibitory regulatory proteins of adenylyl ...
Ronald Adamik +7 more
openaire +3 more sources
Adenosine kinase from Trypanosomacruzi
Biochemical and Biophysical Research Communications, 1982Abstract Adenosine kinase was demonstrated in the soluble fraction of Trypanosoma cruzi . Magnesium is required for activity. ATP and GTP are efficient phosphate donors while p - nitrophenylphosphate is without activity. The pH optimum is high (8.0), it is heat labile and is stabile to freezing (−20° or −80°). It is substrate inhibited,
openaire +3 more sources
Journal of Molecular and Cellular Cardiology, 1999
Adenosine levels present in the interstitial fluid and coronary effluent of the aged heart exceed those of the young adult heart. The present study investigated mechanisms in the Fischer 344 rat heart which may be responsible for the observed differences. (1) Total production of adenosine was determined in isolated perfused hearts by measuring coronary
Lorbar, Mojca +4 more
openaire +4 more sources
Adenosine levels present in the interstitial fluid and coronary effluent of the aged heart exceed those of the young adult heart. The present study investigated mechanisms in the Fischer 344 rat heart which may be responsible for the observed differences. (1) Total production of adenosine was determined in isolated perfused hearts by measuring coronary
Lorbar, Mojca +4 more
openaire +4 more sources
Cyclosporin A and FK506 decrease adenosine kinase activity and adenosine uptake in T-lymphocytes
Journal of Laboratory and Clinical Medicine, 2002Adenosine is a potent modulator of immune function, and adenosine kinase (AK), a rate-limiting enzyme for adenosine uptake and metabolism, is a potential mediator of adenosine regulation. We have found that adenosine uptake increased six- to 18-fold during T-lymphocyte activation.
Beverly S. Mitchell, Jozef Spychala
openaire +3 more sources
European Journal of Pharmacology, 1995
Spinal administration of adenosine analogs and an adenosine kinase inhibitor produces antinociception in thermal threshold tests. In the present study, we determined the effects of N6-cyclohexyladenosine (adenosine A1 receptor selective), 2-[p-(2-carboxyethyl)phenylethylamino]-5'-N-ethyl-carboxamidoadeno sine (CGS-21680) (adenosine A2A receptor ...
Anthony Poon, Jana Sawynok
openaire +3 more sources
Spinal administration of adenosine analogs and an adenosine kinase inhibitor produces antinociception in thermal threshold tests. In the present study, we determined the effects of N6-cyclohexyladenosine (adenosine A1 receptor selective), 2-[p-(2-carboxyethyl)phenylethylamino]-5'-N-ethyl-carboxamidoadeno sine (CGS-21680) (adenosine A2A receptor ...
Anthony Poon, Jana Sawynok
openaire +3 more sources
Diazepam inhibition of adenosine uptake in the CNS: Lack of effect on adenosine kinase
General Pharmacology: The Vascular System, 19831. When tested at concentrations resulting in significant inhibitions of adenosine uptake in brain slices, diazepam and several other benzodiazepines were without effect on brain adenosine kinase. 2. This suggests that the inhibitory effect of the benzodiazepines on adenosine accumulation is at the membrane transport level and not by an inhibition of ...
John W. Hambley, Les P. Davies
openaire +3 more sources
Hypoxia-Induced Inhibition of Adenosine Kinase Potentiates Cardiac Adenosine Release
Circulation Research, 1997Abstract To elucidate the physiological role of the AMP-adenosine metabolic cycle and to investigate the relation between AMP and adenosine formation, the O 2 supply of isolated guinea pig hearts was varied (95% to 10% O 2 ).
Keith Kroll +3 more
openaire +3 more sources