Results 1 to 10 of about 347,631 (311)

Structure of Klebsiella pneumoniae adenosine monophosphate nucleosidase. [PDF]

PLoS ONE, 2022
Klebsiella pneumoniae is a bacterial pathogen that is increasingly responsible for hospital-acquired pneumonia and sepsis. Progressive development of antibiotic resistance has led to higher mortality rates and creates a need for novel treatments. Because
Brian C Richardson, Roger Shek, Wesley C Van Voorhis, Jarrod B French   +3 more
doaj   +3 more sources

Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells

eLife, 2014
Apoptosis is coupled with recruitment of macrophages for engulfment of dead cells, and with compensatory proliferation of neighboring cells. Yet, this death process is silent, and it does not cause inflammation.
Hiroshi Yamaguchi, Toshihiko Maruyama, Yoshihiro Urade, Shigekazu Nagata   +3 more
doaj   +2 more sources

Adenosine monophosphate–activated protein kinase in diabetic nephropathy

Kidney Research and Clinical Practice, 2016
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, and its pathogenesis is complex and has not yet been fully elucidated. Abnormal glucose and lipid metabolism is key to understanding the pathogenesis of DN, which can develop in ...
Yaeni Kim, Cheol Whee Park
doaj   +2 more sources

Adenosine-Metabolizing Enzymes, Adenosine Kinase and Adenosine Deaminase, in Cancer

Biomolecules, 2022
The immunosuppressive effect of adenosine in the microenvironment of a tumor is well established. Presently, researchers are developing approaches in immune therapy that target inhibition of adenosine or its signaling such as CD39 or CD73 inhibiting ...
Galina Zhulai, Eugenia Oleinik, Mikhail Shibaev, Kirill Ignatev   +3 more
doaj   +2 more sources

A Role of Erythrocytes in Adenosine Monophosphate Initiation of Hypometabolism in Mammals [PDF]

Journal of Biological Chemistry, 2010
Biochemical and mechanistic aspects into how various hypometabolic states are initiated in mammals are poorly understood. Here, we show how a state of hypometabolism is initiated by 5′-AMP uptake by erythrocytes. Wild type, ecto-5′-nucleotidase-deficient,
Isadora Susan Daniels, Jianfa Zhang, William G. O’Brien, Zhenyin Tao, Tomoko Miki, Zhaoyang Zhao, Michael R. Blackburn, Cheng Chi Lee   +7 more
openalex   +2 more sources

U-shaped association between plasma cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) levels and myocardial infarction [PDF]

BMC Cardiovascular Disorders
Background The cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS-STING) signaling pathway is closely associated with myocardial infarction (MI).
Quan Zhang, Huiqing Ding, Zhongling Dai, Rukai Yang, Shenghua Zhou, Shi Tai   +5 more
doaj   +2 more sources

In Silico approach for identification, prediction of AMPD1 gene nsSNPs associated with Myoadenylate Deaminase deficiency [PDF]

Journal of Bioscience and Applied Research, 2023
Background: Myoadenylate deaminase deficiency is an autosomal recessive metabolic myopathy caused by mutations in the Adenosine monophosphate deaminase 1 gene.
Abrar Mohamed, Abdelrahman Hamza, Hiba Fadl, Afra Albkrye, Hadeel Ahmed, Hazem Abubaker, Sahar Elbager   +6 more
doaj   +1 more source

Metformin promotes angiogenesis and functional recovery in aged mice after spinal cord injury by adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway

Neural Regeneration Research, 2023
Treatment with metformin can lead to the recovery of pleiotropic biological activities after spinal cord injury. However, its effect on spinal cord injury in aged mice remains unclear.
Jin-Yun Zhao, Xiao-Long Sheng, Cheng-Jun Li, Tian Qin, Run-Dong He, Guo-Yu Dai, Yong Cao, Hong-Bin Lu, Chun-Yue Duan, Jian-Zhong Hu   +9 more
doaj   +1 more source

Selective Fluorimetric Detection of Pyrimidine Nucleotides in Neutral Aqueous Solution with a Styrylpyridine-Based Cyclophane

Chemistry, 2023
A styrylpyridine-containing cyclophane with diethylenetriamine linkers is presented as a host system whose association with representative nucleotides was examined with photometric and fluorimetric titrations.
Julika Schlosser, Julian F. M. Hebborn, Daria V. Berdnikova, Heiko Ihmels   +3 more
doaj   +1 more source

Cyclic adenosine monophosphate (cAMP) signaling in melanocyte pigmentation and melanomagenesis

Pigment Cell & Melanoma Research, 2020
The second messenger cyclic adenosine monophosphate (cAMP) regulates numerous functions in both benign melanocytes and melanoma cells. cAMP is generated from two distinct sources, transmembrane and soluble adenylyl cyclases (tmAC and sAC, respectively ...
J. Bang, J. Zippin
semanticscholar   +1 more source