Results 111 to 120 of about 2,608,509 (268)

The A1 adenosine receptor. Solubilization and characterization of a guanine nucleotide-sensitive form of the receptor.

, 1985
Gary L. Stiles
openalex   +1 more source

The A3 Adenosine Receptor: History and Perspectives

Pharmacological Reviews, 2015
P. Borea, K. Varani, F. Vincenzi, P. Baraldi, M. Tabrizi, S. Merighi, S. Gessi   +6 more
semanticscholar   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Probing adenosine and P2 receptors: Design of novel purines and nonpurines as selective ligands [PDF]

, 2001
Kenneth A. Jacobson
openalex   +1 more source

Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

Journal of Clinical Investigation, 2017
P. Beavis, M. Henderson, Lauren Giuffrida, J. Mills, K. Sek, R. Cross, A. Davenport, Liza B. John, Sherly Mardiana, C. Slaney, R. Johnstone, J. Trapani, J. Stagg, S. Loi, Lev M. Kats, D. Gyorki, M. Kershaw, P. Darcy   +17 more
semanticscholar   +1 more source

Onion‐Mitochondria Inhibit Lipopolysaccharide‐Induced Acute Lung Injury by Shaping Lung Macrophage Mitochondrial Function

Advanced Science, EarlyView.
Proposed model of orally administered onion mitochondria (O‐Mit) uptake by lung macrophages and fuse with macrophage mitochondria (M‐Mit). This fusion reprograms the metabolism of dysfunctional M‐Mit in lipopolysaccharide‐induced murine acute lung injury by modulating dynamin‐related protein 1 (DRP1) phosphorylation and cardiolipin peroxidation ...
Qingbo Xu, Yun Teng, Yinan Huang, Jingyao Mu, Lucy Teng, Hongjia Qian, Qiming Huang, Minmin Liu, Yi Zou, Lifeng Zhang, Michael L Merchant, Xiang Zhang, Jun Yan, Huang‐Ge Zhang   +13 more
wiley   +1 more source

Therapeutic potential of adenosine receptor modulators in cancer treatment. [PDF]

RSC Adv
Maity P, Ganguly S, Deb PK.
europepmc   +1 more source

A_2A adenosine receptor-driven cAMP signaling in olfactory bulb astrocytes is unaffected in experimental autoimmune encephalomyelitis. [PDF]

Front Immunol, 2023
Wendlandt M, Kürten AJ, Beiersdorfer A, Schubert C, Samad-Yazdtchi K, Sauer J, Pinto MC, Schulz K, Friese MA, Gee CE, Hirnet D, Lohr C.   +11 more
europepmc   +1 more source

Regulating PPARG Reduces Lipid Accumulation in Microglia and Promotes Functional Recovery After Spinal Cord Injury

Advanced Science, EarlyView.
Macrophages infiltrate the spinal cord post‐injury, decreasing over time. Microglia phagocytose myelin debris, increasing lipid accumulation. Macrophage deletion improves outcomes, while microglial deletion worsens them. The LD+ microglia subtype shows abnormal Pparg signaling.
Mingran Luo, Jiayun Liu, Yunxin Su, Tao Jiang, Xincan Wu, Peng Gao, Tao Qin, Mengyuan Wu, Qingqing Li, Shujun Zhang, Baorong He, Yongxiang Wang, Xiaodong Guo, Wei Zhou, Shujie Zhao, Jin Fan, Jian Chen, Guoyong Yin   +17 more
wiley   +1 more source

Pharmacological blockade of the CD39/CD73 pathway but not adenosine receptors augments disease in a humanized mouse model of graft‐versus‐host disease

, 2019
Nicholas J. Geraghty, Debbie Watson, Ronald Sluyter   +2 more
openalex   +1 more source