Results 111 to 120 of about 2,712,589 (407)

Emerging adenosine receptor agonists [PDF]

Expert Opinion on Emerging Drugs, 2007
Adenosine receptors (ARs) are a four-member subfamily of G protein-coupled receptors and are major targets of caffeine and theophylline. There are four subtypes of ARs, designated as A1, A2A, A2B and A3. Selective agonists are now available for all four subtypes. Over a dozen of these selective agonists are now in clinical trials for various conditions,
Gao, Zhan-Guo, Jacobson, Kenneth A.
openaire   +3 more sources

Adenosine A2A receptor modulation of hippocampal CA3-CA1 synapse plasticity during associative learning in behaving mice [PDF]

, 2009
© 2009 Nature Publishing Group All rights reservedPrevious in vitro studies have characterized the electrophysiological and molecular signaling pathways of adenosine tonic modulation on long-lasting synaptic plasticity events, particularly for
A de Mendonça, A de Mendonça, A Gruart, A Gruart, A Monopoli, Agnès Gruart, AM Sebastião, AM Thomson, Ana M Sebastião, BM Fontinha, Bruno M Fontinha, C Zocchi, CC Fernandes, CD Woody, CS Rex, DKJE von Lubitz, E Dominguez-del-Toro, E Porras-García, ER Kandel, F Engert, F Suzuki, FS Lee, G Burnstock, G Neves, G Paxinos, GG Turrigiano, HJ Normile, I Gureviciene, I Sahún, JA Ribeiro, JE Kelsey, JM Delgado-Garcia, Joaquim A Ribeiro, José M Delgado-García, JR Whitlock, K Kessey, K Kessey, K Takatsuki, L Boulanger, L Connole, L Winsky, M de Jonge, M El Yacoubi, M El Yacoubi, M Ohno, M Yang, MJ Diógenes, MJ Diógenes, MT Tebano, MT Tebano, N Madroñal, N Rebola, Noelia Madroñal, O Dall'Igna, PA Schwartzkroin, RF Thompson, RS Zucker, S Ferré, S Maren, S Mingote, SR Kopf, T Sakamoto, TV Bliss, TVP Bliss, W Tseng, Y Kishimoto, Y Kishimoto, Y Sekino, Y Wang   +68 more
core   +1 more source

Glepaglutide‐Loaded Foam for the Induction of Mucosal Healing in the Treatment of Inflammatory Bowel Disease

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Glepaglutide (GL), a GLP‐2 analog with an extended half‐life (50 h), is currently undergoing clinical trials for patients with short bowel syndrome. GL requires subcutaneous injection, which poses challenges for potential patient compliance. To address this challenge, we loaded GL into a rectal foam formulation using CO2 as a permeation enhancer to ...
Wunan Zhang, William Van den Bossche, Hafsa Yagoubi, Espoir K Kambale, Khadija Wahni, Tanya Saxena, Léo Guilbaud, Tom G. Moreels, Joris Messens, Ana Beloqui   +9 more
wiley   +1 more source

Targeting adenosine for cancer immunotherapy

Journal of Immunotherapy for Cancer, 2018
Immune checkpoint antagonists (CTLA-4 and PD-1/PD-L1) and CAR T-cell therapies generate unparalleled durable responses in several cancers and have firmly established immunotherapy as a new pillar of cancer therapy.
R. Leone, L. Emens
semanticscholar   +1 more source

Understanding the role of adenosine A2AR heteroreceptor complexes in neurodegeneration and neuroinflammation [PDF]

, 2018
Adenosine is a nucleoside mainly formed by degradation of ATP, located intracellularly or extracellularly, and acts as a neuromodulator. It operates as a volume transmission signal through diffusion and flow in the extracellular space to modulate the ...
Agnati, Agnati, Agnati, Angot, Batalha, Beggiato, Besancon, Bockaert, Boison, Boison, Borroto-Escuela, Borroto-Escuela, Borroto-Escuela, Borroto-Escuela, Borroto-Escuela, Borroto-Escuela, Borroto-Escuela, Borroto-Escuela, Borroto-Escuela, Brugarolas, Cabello, Canals, Carriba, Cervetto, Christa E. Müller, Cristovao-Ferreira, Cristovao-Ferreira, Cui, Dasiel O. Borroto-Escuela, Decressac, Dehay, Diogenes, Fagni, Feoktistov, Ferre, Ferreira, Ferreira, Fishman, Flajolet, Fredholm, Fredholm, Fujiwara, Fuxe, Fuxe, Fuxe, Fuxe, Fuxe, Fuxe, Fuxe, Fuxe, Fuxe, Fuxe, Gemma Navarro, Gomes, Gomes, Goncalves, Groeneweg, Guescini, Hill, Hillion, Hinz, Hinz, Hu, Husi, Iliff, Jeronimo-Santos, Jessen, Kalivas, Kalivas, Kennedy, Kjell Fuxe, Kornau, Laurent, Lee, Linden, Little, Liu, Lopes, Matos, Müller, Navarro, Navarro, Navarro, Navarro, Navarro, Oakley, Orr, Pellerin, Perroy, Rafael Franco, Rebola, Rebola, Rodrigues, Santiago, Sattler, Saura, Simons, Sonja Hinz, Su, Tebano   +99 more
core   +1 more source

HGF/c‐Met Axis‐Targeted Nanotherapy via GSH‐Responsive Polymer Platforms Suppresses Uveal Melanoma Metastasis

Advanced Healthcare Materials, EarlyView.
To suppress uveal melanoma metastasis (UM), the GSH‐responsive polymer named NP@Oxa/Criz has been successfully prepared. NP@Oxa/Criz selectively accumulates in UM tumors, targeting HGF/c‐Met Axis to undermine the stemness and metastasis of UM while triggering immunogenic cell death through DAMPs release to boost anti‐tumor immunity.
Hui Tao, Hanhan Liu, Hanchen Zhang, Hong Ren, Binyu Wen, Jing Zhang, Jiaqi Du, Ziyi Cai, Zhihong Deng   +8 more
wiley   +1 more source

Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis

Advanced Materials, EarlyView.
A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen, Yingjie Fan, Tomas Germanas, Langston Tillman, Jinhong Li, Abigail L. Blenko, Ralph R. Weichselbaum, Wenbin Lin   +7 more
wiley   +1 more source

Adenosine Receptors and Wound Healing, Revised

The Scientific World Journal, 2006
Recent studies have demonstrated that application of topical adenosine A2A receptor agonists promotes more rapid wound closure and clinical studies are currently underway to determine the utility of topical A2A adenosine receptor agonists in the therapy ...
Bruce M. Cronstein
doaj   +1 more source

Adora2b Adenosine Receptor Engagement Enhances Regulatory T Cell Abundance during Endotoxin-Induced Pulmonary Inflammation

PLoS ONE, 2012
Anti-inflammatory signals play an essential role in constraining the magnitude of an inflammatory response. Extracellular adenosine is a critical tissue-protective factor, limiting the extent of inflammation. Given the potent anti-inflammatory effects of
Heidi Ehrentraut, J. Westrich, H. Eltzschig, E. Clambey   +3 more
semanticscholar   +1 more source

Evidence for, and characterization of, a lipopolysaccharide-inducible adenosine A2 receptor in human tracheal gland serous cells [PDF]

, 1995
Human tracheal glands are considered as the principle secretory structures in the bronchotracheal tree. In earlier studies, we successfully performed primary cultures of human tracheal gland (HTG) serous cells and noted that these cells were responsive ...
Figarella, C., Kammouni, W., Merten, M.D.   +2 more
core   +1 more source