Results 111 to 120 of about 2,801,899 (401)

The role of the neuromodulator adenosine in alcohols actions. [PDF]

, 1997
The interaction between the neuromodulator adenosine and adenosine receptors on the surface of neurons modifies the neurons responses to neurotransmitters.
Diamond, Ivan, Dohrman, D, Gordon, A
core  

Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system [PDF]

, 2013
The fine control of molecules mediating communication in the nervous system is key to adjusting neuronal signaling during development and in maintaining the stability of established networks in the face of altered sensory input.
Ales eBalik, Andrew Charles Penn, Andrew Charles Penn, Ingo H Greger   +3 more
core   +2 more sources

Targeting adenosine for cancer immunotherapy

Journal of Immunotherapy for Cancer, 2018
Immune checkpoint antagonists (CTLA-4 and PD-1/PD-L1) and CAR T-cell therapies generate unparalleled durable responses in several cancers and have firmly established immunotherapy as a new pillar of cancer therapy.
R. Leone, L. Emens
semanticscholar   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Heteroreceptor complexes and their allosteric receptor-receptor interactions in the central nervous system. Focus on examples from Dopamine D2 and Serotonin 5-HT1a receptors [PDF]

, 2018
GPCR interacting proteins (specially β- arrestin) and their receptor-protein interactions are also covered but their interactions with the allosteric receptor-receptor interactions in heteroreceptor complexes remain to be elucidated.
Corrales Ferro, Fidel
core   +1 more source

Communication over the network of binary switches regulates the activation of A$_{2A}$ adenosine receptor

, 2014
Dynamics and functions of G-protein coupled receptors (GPCRs) are accurately regulated by the type of ligands that bind to the orthosteric or allosteric binding sites.
Choi, Sun, Hyeon, Changbong, Lee, Yoonji
core   +3 more sources

Adenosine A2A receptors: localization and function [PDF]

, 2015
Adenosine is an endogenous purine nucleoside present in all mammalian tissues, that originates from the breakdown of ATP. By binding to its four receptor subtypes (A1, A2A, A2B, and A3), adenosine regulates several important physiological functions at ...
A Brand, A Gharib, A Kalhan, A Montinaro, A Mori, A Nishi, A Pinna, A Santos-Rodrigues Dos, A Sato, A Tomaru, AA Link, AE King, AK Dixon, AM Mott, AM Sebastiao, AM Sebastiao, AS Awad, B Sperlagh, B Sperlagh, B Sperlagh, BB Fredholm, BB Fredholm, BB Fredholm, BB Fredholm, BB Fredholm, BB Fredholm, BD Hettinger, C Hammarberg, C Ledent, C Quiroz, C Salgado Garcia, CD Bonan, CM Anderson, CN Wilson, CP Sevigny, D Boison, D Boison, D Boison, D Joel, DC Cassada, DJ Brooks, DJ LaPar, DK Glover, DL Rosin, DL Rosin, DN Bowser, E Dare, E Mazzon, F Ciruela, F Ciruela, F Squadrito, FE Parkinson, G Burnstock, G Burnstock, G Burnstock, G Ghimire, G Haskó, G Schulte, G Schulte, GA Higgins, GE Garcia, GG Yegutkin, GM Halliday, GW Sullivan, H Kobayashi, H Zimmermann, HJ Groenewegen, I Feoktistov, J Espinosa, J Fastbom, J Kang, J Snel, J Tchekalarova, JA Ribeiro, JF Chen, JF Chen, JG Dobson Jr, JM Dickenson, JP Headrick, JR Fozard, JS Fink, K Biber, K Fuxe, K Yamada, KD Pierce, L Antonioli, L Antonioli, L Antonioli, L Belardinelli, L Wells, LC Rump, LP Shearman, M Canals, M Fornai, M Katebi, M Kawamura Jr, M Kurokawa, M Kurokawa, M Lazarus, M Matos, M Matos, M Milanese, M Morelli, M Morelli, M Odashima, M O’Neill, M Pouliot, M Reddington, M Schindler, M Storr, MA Ruiz, MA Schwarzschild, MA Souza, MA Trevethick, MC Wittendorp, MD Desrosiers, MD Okusa, MF Jarvis, MJ Bours, MJ Hussey, MJ Wall, MP Abbracchio, MP Abbracchio, MS Hershfield, N Ates, N Cabello, N Levens, N Rebola, N Rebola, N Simola, O Bonneau, O Cauli, O Pascual, P Carriba, P Carriba, P Popoli, P Popoli, P Svenningsson, P Svenningsson, P Svenningsson, P Svenningsson, P Voorn, PA LeWitt, PJ Gebicke-Haerter, R Rahimian, RA Cunha, RA Cunha, RA Cunha, RD Prediger, RH Al-Mashhadi, RJ Rodrigues, S Ferre, S Ferré, S Ferré, S Ferré, S Ferré, S James, S Latini, S Latini, S Revan, SA Baldwin, SA Hunsucker, SA Rivkees, SA Rivkees, SG Khasar, SJ Augood, SJ Brown, SM Duffy, SN Schiffmann, SN Schiffmann, SP Alexander, SW Schoen, T Eckle, T Kadowaki Horita, T Ochiishi, T Othman, TC Bingham, TF Wang, TH Adair, TV Dunwiddie, TV Dunwiddie, V Ralevic, W Hauber, Y Mizuno, Y Pankratov, Y Pankratov, Y Zhong, Z Díaz-Cabiale, Z Justinova, Z Kovacs, Z Selmeczy   +190 more
core   +1 more source

The development and immunosuppressive functions of CD4+ CD25+ FoxP3+ regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway

Front. Immun., 2012
The A2A adenosine receptor (A2AR)-mediated immunosuppression is firmly implicated in the life-saving down-regulation of collateral tissue damage during the anti-pathogen immune response and in highly undesirable protection of cancerous tissues during ...
A. Ohta, R. Kini, Akiko Ohta, Meenakshi Subramanian, M. Madasu, M. Sitkovsky   +5 more
semanticscholar   +1 more source

Emerging 2D Materials and Their Hybrid Nanostructures for Label‐Free Optical Biosensing: Recent Progress and Outlook

Advanced Functional Materials, EarlyView.
This review highlights recent advances in label‐free optical biosensors based on 2D materials and rationally designed mixed‐dimensional nanohybrids, emphasizing their synergistic effects and novel functionalities. It also discusses multifunctional sensing platforms and the integration of machine learning for intelligent data analysis.
Xinyi Li, Yonghao Fu, Yuehe Lin, Dan Du
wiley   +1 more source

Altered expression of adenosine A1 receptor in the paraventricular thalamus and its role in the regulation of sleep

陆军军医大学学报
Objective‍　‍To explore the expression profile of adenosine A1 receptor in the paraventricular thalamic nucleus (PVT) in wakefulness/sleep state and its role in regulating sleep.
ZHU Yifeng, WANG Na, HU Junya
doaj   +1 more source