Results 191 to 200 of about 350,006 (309)

Pancreatic Cancer‐Derived Extracellular Vesicles Enriched with miR‐223‐5p Promote Skeletal Muscle Wasting Associated with Cachexia

Advanced Science, EarlyView.
EVs and EV‐microRNAs (miRNAs) mediate PDAC‐skeletal muscle communication. miR‐223‐5p reduces METTL14 transcription by targeting MAFA, which subsequently decreases m6A methylation in skeletal muscles, ultimately leading to muscle wasting. This study highlights the absorption of miRNA in PDAC‐derived EVs by skeletal muscles and reveals a previously ...
Kangjing Xu, Rongxi Shen, Li Zhang, Xuejin Gao, Xinbo Wang, Changhua Zhang, Xi Chen, Xinying Wang   +7 more
wiley   +1 more source

Adenosine receptor subtype modulators: Insight into molecular mechanisms and their therapeutic application. [PDF]

Am J Transl Res
Solanki N, Dodiya R, Vejpara D, Azad S, Patel M, Patel S, Shah U, Soni A, Maheshwari R, Navale A, Patel A, Patel S, Sheth D, Tirgar P, R R.   +14 more
europepmc   +1 more source

Caffeine for Prevention of Alzheimer's Disease: Is the A_2A Adenosine Receptor Its Target? [PDF]

Biomolecules, 2023
Merighi S, Travagli A, Nigro M, Pasquini S, Cappello M, Contri C, Varani K, Vincenzi F, Borea PA, Gessi S.   +9 more
europepmc   +1 more source

Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis

Advanced Science, EarlyView.
Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves, Darius Lane, Adam Wahida, Md. Jakaria, Pawel Kalinowski, Adam Southon, Abdel Ali Belaidi, Teresa Samperi‐Esteve, Triet Phu Minh Nguyen, Peng Lei, Marcus Krueger, Stefan Mueller, Marcus Conrad, Puja Agarwal, Sue E Leurgans, Julie Schneider, Ashley I. Bush, Scott Ayton   +17 more
wiley   +1 more source

Adenosine Receptor Mechanisms Underlying Bladder Dysfunction in Male Rats With Bladder Outlet Obstruction. [PDF]

Neurourol Urodyn
Takaoka EI, Kurobe M, Matsuoka K, Kamijo T, Kimura S, Watton PN, Robertson AM, Yoshimura N.   +7 more
europepmc   +1 more source

Single-molecule visualization of human A_2A adenosine receptor activation by a G protein and constitutively activating mutations. [PDF]

Commun Biol, 2023
Wei S, Pour NG, Tiruvadi-Krishnan S, Ray AP, Thakur N, Eddy MT, Lamichhane R.   +6 more
europepmc   +1 more source

Chronic caffeine ingestion sensitizes the A1 adenosine receptor-adenylate cyclase system in rat cerebral cortex.

, 1986
R M Green, Gary L. Stiles
openalex   +1 more source

GHSR‐Foxo1 Signaling in Macrophages Promotes Liver Fibrosis via Inflammatory Response and Hepatic Stellate Cell Activation

Advanced Science, EarlyView.
Macrophage GHSR‐Foxo1 axis regulates CCl4‐induced liver fibrosis by promoting inflammation and TGF‐β1‐mediated HSC activation. GHSR activates PKA‐dependent phosphorylation of Foxo1 at serine 273, promoting macrophage pro‐inflammatory polarization to enhance the production of pro‐inflammatory cytokines that damage hepatocytes, thereby inducing liver ...
Da Mi Kim, Quan Pan, Zeyu Liu, Weiqi Ai, Hye Won Han, Sakhila K. Banu, Robert Y.L. Tsai, Gus A. Wright, Shaodong Guo, Yuxiang Sun   +9 more
wiley   +1 more source

Bile acids inhibit equilibrative adenosine transport to alter adenosine receptor signaling in cholestasis. [PDF]

J Biol Chem
Joshi A, Chen S, Rahman FM, Nair S, Cheng X, Govindarajan R.   +5 more
europepmc   +1 more source

A_2B adenosine receptor activation and modulation by protein kinase C. [PDF]

iScience, 2023
Gao ZG, Levitan IM, Inoue A, Wei Q, Jacobson KA.   +4 more
europepmc   +1 more source