Results 201 to 210 of about 350,006 (309)

A Longitudinal Study Reveals Metabolomic Markers for Individuals at Risk, Disease Severity, and Treatment Response in Rheumatoid Arthritis

Advanced Science, EarlyView.
This study investigates plasma metabolomic biomarkers for rheumatoid arthritis (RA) development using longitudinal data from 209 RA patients and 56 individuals at risk. It also reveals metabolic signatures linked to severity, age, sex, and anti‐citrullinated protein autoantibody in RA.
Chenxi Zhu, Jiayi Xu, Siyu He, Qian Niu, Yi Liu, Xin Guo, Huifang Hu, Rui Sun, Tao Chen, Yan Liu, Zhiqiang Xu, Na Jiang, Lipu Yao, Lunzhi Dai, Qinghua Zou, Fanxin Zeng, Liesu Meng, Inger Gjertsson, Rikard Holmdahl, Bin Yang, Dan Du, Yi Zhao   +21 more
wiley   +1 more source

A_2A Adenosine Receptor Antagonists and Their Efficacy in Rat Models of Parkinson's Disease. [PDF]

Cells
Spinaci A, Buccioni M, Dal Ben D, Francucci B, Klotz KN, Marucci G, Simola N, Morelli M, Pinna A, Volpini R, Lambertucci C.   +10 more
europepmc   +1 more source

Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset

Advanced Science, EarlyView.
This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu, Zhengyuan Zhou, Sascha Schäuble, Wolfgang Vivas, Karen Dlubatz, Michael Bauer, Sebastian Weis, Mervyn Singer, Roman Lukaszewski, Gianni Panagiotou   +9 more
wiley   +1 more source

A_2B adenosine receptor signaling and regulation. [PDF]

Purinergic Signal
Gao ZG, Haddad M, Jacobson KA.
europepmc   +1 more source

Adenosine receptor involvement in a delayed phase of myocardial protection 24 hours after ischemic preconditioning. [PDF]

, 1994
Gary F. Baxter, Michael Marber, Vanlata C. Patel, Derek M. Yellon   +3 more
openalex   +1 more source

Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling

Advanced Science, EarlyView.
The intestinal clock controls the expression of an adenosine enzyme that modulates systemic adenosine level and A1R signaling in the hippocampus, and in turn, cognitive function involving long‐term potentiation and BDNF‐dependent synaptic changes.
Min Chen, Fugui Zhang, Yifei Xiao, Xuejun Jiang, Zhiqian Yan, Jinyi Wang, Xiting Lv, Jialu Cui, Linna Ha, Hui Chen, Yongkang Dang, Zifei Qin, Jing Yang, Baojian Wu   +13 more
wiley   +1 more source

Unlocking the adenosine receptor mechanism of the tumour immune microenvironment. [PDF]

Front Immunol
Han Y, Dong C, Hu M, Wang X, Wang G.
europepmc   +1 more source

Assay-Dependent Inverse Agonism at the A₃ Adenosine Receptor: When Neutral Is Not Neutral. [PDF]

ACS Pharmacol Transl Sci, 2023
Pottie E, Suresh RR, Jacobson KA, Stove CP.   +3 more
europepmc   +1 more source

Stimulation of adenosine A1 receptors and bradykinin receptors, which act via different G proteins, synergistically raises inositol 1,4,5-trisphosphate and intracellular free calcium in DDT1 MF-2 smooth muscle cells. [PDF]

, 1992
Pär Gerwins, B.B. Fredholm
openalex   +1 more source

Metal‐Ligand Complexes as Multifunctional Platforms for Photo‐Activated Cancer Therapy

Advanced Science, EarlyView.
Metal‐ligand complexes serve as multifunctional platforms for photo‐activated cancer therapy, facilitating photothermal and photodynamic effects through light absorption and reactive oxygen species generation. This review categorizes these complexes by ligand and metal types, examines their roles in combined therapeutic approaches, and explores ...
Jeonga Kim, Saehan Choi, Yoonsung Nam
wiley   +1 more source