Results 201 to 210 of about 2,801,899 (401)

Adenosine Receptor mRNA Expression in Frontal Cortical Neurons in Schizophrenia. [PDF]

Cells, 2023
Sahay S, Devine EA, McCullumsmith RE, O'Donovan SM.   +3 more
europepmc   +1 more source

A2B adenosine receptor-triggered intracellular calcium mobilization: Cell type-dependent involvement of Gi, Gq, Gs proteins and protein kinase C [PDF]

Zhan-Guo Gao, Ray R. Gao, Christina Meyer, Kenneth A. Jacobson   +3 more
openalex   +1 more source

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source

Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

Journal of Clinical Investigation, 2017
P. Beavis, M. Henderson, Lauren Giuffrida, J. Mills, K. Sek, R. Cross, A. Davenport, Liza B. John, Sherly Mardiana, C. Slaney, R. Johnstone, J. Trapani, J. Stagg, S. Loi, Lev M. Kats, D. Gyorki, M. Kershaw, P. Darcy   +17 more
semanticscholar   +1 more source

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source

Structural Requirements for RNA Editing in Glutamate Receptor Pre-mRNAs by Recombinant Double-stranded RNA Adenosine Deaminase [PDF]

, 1996
Stefan Maas, Thorsten Melcher, Anne Herb, Peter H. Seeburg, Walter Keller, Sabine Krause, Miyoko Higuchi, Mary A. O’Connell   +7 more
openalex   +1 more source

Datasets and supplemental data for 'Deep Learning-based Design and Screening of Benzimidazole-pyrazine derivatives as Adenosine A2B Receptor Antagonists'

, 2023
Rui Qin, Hao Zhang, Weifeng Huang, Zhenglin Shao, Jinping Lei   +4 more
openalex   +1 more source

The A3 Adenosine Receptor: History and Perspectives

Pharmacological Reviews, 2015
P. Borea, K. Varani, F. Vincenzi, P. Baraldi, M. Tabrizi, S. Merighi, S. Gessi   +6 more
semanticscholar   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Caffeine-associated reduction in patent ductus arteriosus is mediated in part by adenosine receptor antagonism. [PDF]

Am J Physiol Heart Circ Physiol
Crockett SL, Su RL, Sekulich DC, Goins KA, Montero A, Boatwright N, Berger CD, Yarboro MT, Paria BC, Herington JL, Siricilla S, Mettler BA, Bichell DP, Allison BJ, Reese J, Shelton EL.   +15 more
europepmc   +1 more source