Results 211 to 220 of about 2,608,509 (268)

2-Substituted (N)-Methanocarba A₃ Adenosine Receptor Agonists: In Silico, In Vitro, and In Vivo Characterization. [PDF]

ACS Pharmacol Transl Sci
Tosh DK, Pavan M, Cronin C, Pottie E, Wan TC, Chen E, Lewicki SA, Campbell RG, Gao ZG, Auchampach JA, Stove CP, Liang BT, Jacobson KA.   +12 more
europepmc   +1 more source

Biomimetic Organic Nanozyme as Tumor Vaccines for Targeted Suppression of Ammonia‐Induced T Lymphocyte Death to Augment Breast Cancer Immunotherapy

Advanced Science, EarlyView.
The organic nanozyme IR‐IHpd, which has NIR‐PDT and POD‐like activity, is designed for continuous ROS generation. It is co‐encapsulated with CB‐839 and coated with DC membranes to simultaneously target tumors and T cells. Under NIR irradiation, immunogenic cell death is activated. Concurrently, CB‐839 suppresses ammonia‐induced T lymphocyte death (AITD)
Meng Suo, Deyi Yang, Mingpu Yang, Jue Wang, Dingfeng Zhang, Daoming Zhu, Qingyong Xu, Yanni Song   +7 more
wiley   +1 more source

A randomized phase 1 study of safety, tolerability, and pharmacokinetics of MK-1088, a novel dual adenosine receptor antagonist, in healthy adult participants. [PDF]

Invest New Drugs
Gupta P, Chatterjee M, Kim Y, Deschamps K, Lemoine L, Van Dyck K, Matthews CZ, Rottey S, Stoch A, Lai E.   +9 more
europepmc   +1 more source

The Immune Microenvironment in Liver Cancer: From Analysis to Targeting

Advanced Science, EarlyView.
This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan, Hao Li, Jian Xue, Yourong Duan, Jin Sun, Meng Niu   +5 more
wiley   +1 more source

Inactivation of adenosine receptor 2A suppresses endothelial-to-mesenchymal transition and inhibits subretinal fibrosis in mice. [PDF]

Sci Transl Med
Yang Q, Cai Y, Ma Q, Xiong A, Xu P, Zhang Z, Xu J, Zhou Y, Liu Z, Zhao D, Asara J, Li W, Shi H, Caldwell RB, Sodhi A, Huo Y.   +15 more
europepmc   +1 more source

A2B adenosine receptor-triggered intracellular calcium mobilization: Cell type-dependent involvement of Gi, Gq, Gs proteins and protein kinase C [PDF]

Zhan-Guo Gao, Ray R. Gao, Christina Meyer, Kenneth A. Jacobson   +3 more
openalex   +1 more source

Cortical Microvascular Pulsatility in the Aging Mouse Brain and the Confounding Effects of Anesthesia

Advanced Science, EarlyView.
Multi‐modal optical imaging reveals microvascular pulsatility in the brain cortex of awake and anaesthetized mice. Awake hemodynamics in male mice are found to be remarkably stable until late life, with flow pulsatility being significantly higher than in females, despite similar average perfusion.
Mia Viuf Skøtt, Elizaveta Melnikova, Eugenio Gutiérrez, Vladimir Matchkov, Leif Østergaard, Dmitry D Postnov   +5 more
wiley   +1 more source

A_2B adenosine receptor-triggered intracellular calcium mobilization: Cell type-dependent involvement of G_i, G_q, G_s proteins and protein kinase C. [PDF]

Purinergic Signal
Gao ZG, Gao RR, Meyer CK, Jacobson KA.
europepmc   +1 more source

Intelligent Theranostic Systems Enabled by Aggregation‐Induced Emission in Precision Medicine

Aggregate, EarlyView.
Aggregation‐induced emission (AIE) luminogens are driving a new generation of intelligent theranostic systems that integrate high‐fidelity imaging and multifunctional therapy. This review highlights how AIEgens, through restriction of intramolecular motion (RIM), enable deep‐tissue NIR‐II imaging, ultrasensitive biosensing, CRISPR‐assisted gene ...
Qinqin Huang, Yanyu Chen, Shile Wang, Kan Liu, Xing‐Zhong Zhao, Xiaobo Mao, Ben Zhong Tang, Lang Rao   +7 more
wiley   +1 more source

Distribution of adenosine receptors in human sclera fibroblasts.

, 2008
Dongmei Cui, Klaus Trier, Xiang Chen, Junwen Zeng, Xiao Yang, Jianmin Hu, Jian Ge   +6 more
openalex   +1 more source