Results 231 to 240 of about 2,608,509 (268)

Metabolism‐Regulating Nanomedicines for Cancer Therapy

Advanced NanoBiomed Research, EarlyView.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source

Nanobiotechnology‐Based Approaches for Targeted Glioma Therapy

Advanced NanoBiomed Research, EarlyView.
Nanoparticle systems cross the blood–brain barrier to deliver drugs precisely to glioma cells. Lipid, polymeric, and magnetic carriers enable controlled release, tumor targeting, and microenvironment modulation. These nanoplatforms enhance chemotherapy, radiotherapy, and immunotherapy, improving therapeutic efficacy while reducing systemic toxicity ...
Jinwei Li, Yibo He, Yang Zhang, Lining Arnold Ju, Yao Wang, Jianxuan Zhou, Yinying Chai, Xuhui Hui, ShiYuan Tong, Si Zhang, Yanli Tan, Yinyan Wang   +11 more
wiley   +1 more source

Aluminum Exposure Impairs Electrochemically Measured Vesicular Storage and Exocytosis via Iron Homeostasis Dysregulation

Angewandte Chemie, EarlyView.
Al3+ competes with Fe3+ for transferrin (Tf) binding and enters cells via transferrin receptor (TfR)‐mediated endocytosis, disrupting cellular iron homeostasis. Intracellular vesicle impact electrochemical cytometry (IVIEC) and single‐cell amperometry (SCA), which record the oxidation of dopamine, reveal increased neurotransmitter storage and ...
Shi‐Hua Chen, Chaoyi Gu, Xing‐Jiu Huang, Andrew G. Ewing   +3 more
wiley   +1 more source

Cantharidin and sodium fluoride attenuate the negative inotropic effect of the A₁-adenosine receptor agonist N⁶-(R)-phenylisopropyl adenosine in isolated human atria. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Schwarz R, Hofmann B, Gergs U, Neumann J.   +3 more
europepmc   +1 more source

A Triple Threat Against Ovarian Cancer: Os(II)‐Pt(IV)‐Ceritinib Conjugates for Photodynamic Therapy, Chemotherapy, and Immunogenic Cell Death Induction

Angewandte Chemie, EarlyView.
A novel Os(II)‐Pt(IV)‐Ceritinib (Os‐Pt‐Cer) conjugate enables triple‐action anticancer therapy by integrating photodynamic therapy, chemotherapy, and immunogenic cell death (ICD) induction into a single molecule. Upon near‐infrared light activation, this heterobimetallic complex exhibits potent antiproliferative effects in ovarian cancer models ...
Marta Redrado, Sourav Acharya, Pierre Mesdom, Tomer Babu, James W. Southwell, Laiane S. Oliveira, Samia Hidalgo, Philippe Arnoux, Céline Frochot, Dan Gibson, Gilles Gasser   +10 more
wiley   +1 more source

A novel A2a adenosine receptor inhibitor effectively mitigates hepatic fibrosis in a metabolic dysfunction-associated steatohepatitis mouse model. [PDF]

Int J Biol Sci
Park S, Hwang S, Sun J, Jeon KH, Sheen N, Shin S, Kim TH, Lee YS, Seo W, Ryu JS, Kwon Y.   +10 more
europepmc   +1 more source

Staphylococcus aureus suppresses the pentose phosphate pathway in human neutrophils via the adenosine receptor A2aR to enhance intracellular survival. [PDF]

mBio
Vozza EG, Daly CM, O'Rourke SA, Fitzgerald HK, Dunne A, McLoughlin RM.   +5 more
europepmc   +1 more source

Structural Modification and Biological Evaluation of 2,8-Disubstituted Adenine and Its Nucleosides as A_2A Adenosine Receptor Antagonists: Exploring the Roles of Ribose at Adenosine Receptors. [PDF]

J Med Chem
Kim G, Jarhad DB, Lee G, Kim G, Hou X, Yu J, Lee CS, Warnick E, Gao ZG, Ahn SY, Kwak D, Park K, Lee SD, Park TU, Jung SY, Lee JH, Choi JR, Kim M, Kim D, Kim B, Jacobson KA, Jeong LS.   +21 more
europepmc   +1 more source

Correction: A2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models. [PDF]

J Immunother Cancer
europepmc   +1 more source

Targeting the A3 adenosine receptor to treat cytokine release syndrome in cancer immunotherapy

, 2019
S Cohen, P Fishman
openalex   +1 more source