Results 51 to 60 of about 370,006 (352)

Multi‐Functional Small Molecule Alleviates Fracture Pain and Promotes Bone Healing

Advanced Science, 2023
Bone injuries such as fractures are one major cause of morbidities worldwide. A considerable number of fractures suffer from delayed healing, and the unresolved acute pain may transition to chronic and maladaptive pain.
Yu‐Ru V. Shih, David Kingsley, Hunter Newman, Jiaul Hoque, Ankita Gupta, B. Duncan X. Lascelles, Shyni Varghese   +6 more
doaj   +1 more source

Rapid Eye Movement Sleep Deprivation Combined With Fluoxetine Protects Against Depression-Induced Damage and Apoptosis in Rat Hippocampi via A1 Adenosine Receptor

Frontiers in Psychiatry, 2021
Background: Rapid eye movement sleep deprivation (REMSD) and fluoxetine affect depression, yet the detailed molecular mechanisms were not clear.Methods: Rat depression chronic unpredictable stress was constructed, and the body weight of rats was measured.
Xuan Ju, Shengdong Wang, Pan Yan, Chunyan Zhu, Xiwen Hu, Jiezheng Dong, Zhonglin Tan   +6 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

FSCPX, a Chemical Widely Used as an Irreversible A1 Adenosine Receptor Antagonist, Modifies the Effect of NBTI, a Nucleoside Transport Inhibitor, by Reducing the Interstitial Adenosine Level in the Guinea Pig Atrium

Molecules, 2018
Based on in silico results, recently we have assumed that FSCPX, an irreversible A1 adenosine receptor antagonist, inhibits the action of NBTI that is apparent on E/c curves of adenosine receptor agonists.
Tamas Erdei, Adrienn Monika Szabo, Nora Lampe, Katalin Szabo, Rita Kiss, Judit Zsuga, Csaba Papp, Akos Pinter, Andras Jozsef Szentmiklosi, Zoltan Szilvassy, Bela Juhasz, Rudolf Gesztelyi   +11 more
doaj   +1 more source

Understanding the role of adenosine A2AR heteroreceptor complexes in neurodegeneration and neuroinflammation [PDF]

, 2018
Adenosine is a nucleoside mainly formed by degradation of ATP, located intracellularly or extracellularly, and acts as a neuromodulator. It operates as a volume transmission signal through diffusion and flow in the extracellular space to modulate the ...
Agnati, Agnati, Agnati, Angot, Batalha, Beggiato, Besancon, Bockaert, Boison, Boison, Borroto-Escuela, Borroto-Escuela, Borroto-Escuela, Borroto-Escuela, Borroto-Escuela, Borroto-Escuela, Borroto-Escuela, Borroto-Escuela, Borroto-Escuela, Brugarolas, Cabello, Canals, Carriba, Cervetto, Christa E. Müller, Cristovao-Ferreira, Cristovao-Ferreira, Cui, Dasiel O. Borroto-Escuela, Decressac, Dehay, Diogenes, Fagni, Feoktistov, Ferre, Ferreira, Ferreira, Fishman, Flajolet, Fredholm, Fredholm, Fujiwara, Fuxe, Fuxe, Fuxe, Fuxe, Fuxe, Fuxe, Fuxe, Fuxe, Fuxe, Fuxe, Gemma Navarro, Gomes, Gomes, Goncalves, Groeneweg, Guescini, Hill, Hillion, Hinz, Hinz, Hu, Husi, Iliff, Jeronimo-Santos, Jessen, Kalivas, Kalivas, Kennedy, Kjell Fuxe, Kornau, Laurent, Lee, Linden, Little, Liu, Lopes, Matos, Müller, Navarro, Navarro, Navarro, Navarro, Navarro, Oakley, Orr, Pellerin, Perroy, Rafael Franco, Rebola, Rebola, Rodrigues, Santiago, Sattler, Saura, Simons, Sonja Hinz, Su, Tebano   +99 more
core   +1 more source

Adenosine receptors and asthma [PDF]

British Journal of Pharmacology, 2008
The accumulation of evidence implicating a role for adenosine in the pathogenesis of asthma has led to investigations into all adenosine receptor subtypes as potential therapeutic targets for the treatment of asthma. Selective A1receptor antagonists are currently in preclinical development since adenosine has been shown experimentally to mediate ...
Brown, R A, Spina, D, Page, C P
openaire   +3 more sources

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

504 Topical adenosine treatment inhibits inflammation and mucus production in viral acute rhinosinusitis

Journal of Clinical and Translational Science, 2023
OBJECTIVES/GOALS: Viral acute rhinosinusitis (ARS), a.k.a, the common cold, affects millions every year. The symptoms caused by viral ARS dramatically affect the general well-being and functional levels of patients, causing work and school absence, and ...
Xiaoyang Hua, Kody A. Waldstein, Maria Ganama, Steven M. Varga, Stephen Tilley, Xiaoyang Hua   +5 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Adenosine A1 Receptor-Mediated Attenuation of Reciprocal Dendro-Dendritic Inhibition in the Mouse Olfactory Bulb

Frontiers in Cellular Neuroscience, 2018
It is well described that A1 adenosine receptors inhibit synaptic transmission at excitatory synapses in the brain, but the effect of adenosine on reciprocal synapses has not been studied so far.
Kristina Schulz, Natalie Rotermund, Katarzyna Grzelka, Jan Benz, Christian Lohr, Daniela Hirnet   +5 more
doaj   +1 more source