Results 71 to 80 of about 2,712,589 (407)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

How Are Adenosine and Adenosine A_2A Receptors Involved in the Pathophysiology of Amyotrophic Lateral Sclerosis?

Biomedicines, 2021
Adenosine is extensively distributed in the central and peripheral nervous systems, where it plays a key role as a neuromodulator. It has long been implicated in the pathogenesis of progressive neurogenerative disorders such as Parkinson’s disease, and ...
Akihisa Mori, Brittany Cross, Shinichi Uchida, Jill Kerrick Walker, Robert Ristuccia   +4 more
doaj   +1 more source

Clostridium difficile toxins or infection induce upregulation of adenosine receptors and IL-6 with early pro-inflammatory and late anti-inflammatory pattern [PDF]

Brazilian Journal of Medical and Biological Research, 2020
Clostridium difficile causes intestinal inflammation, which increases adenosine. We compared the expression of adenosine receptors (AR) subtypes A1, A2A, A2B, and A3 in HCT-8, IEC-6 cells, and isolated intestinal epithelial cells, challenged or not with ...
D.A. Foschetti, M.B. Braga-Neto, D. Bolick, J. Moore, LA. Alves, CS. Martins, LE. Bomfin, AAQA. Santos, RFC. Leitão, GAC. Brito, CA. Warren   +10 more
doaj   +1 more source

Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation.

Journal of Clinical Investigation, 2014
Acute stimulation of cardiac β-adrenoceptors is crucial to increasing cardiac function under stress; however, sustained β-adrenergic stimulation has been implicated in pathological myocardial remodeling and heart failure.
Y. Sassi, A. Ahles, Dong-Jiunn Jeffery Truong, Younis Baqi, Sang-Yong Lee, B. Husse, J. Hulot, A. Foinquinos, T. Thum, C. Müller, A. Dendorfer, B. Laggerbauer, S. Engelhardt   +12 more
semanticscholar   +1 more source

Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor. [PDF]

Proceedings of the National Academy of Sciences, 1992
We have previously reported the selective amplification of several rat striatal cDNA sequences that encode guanine nucleotide-binding regulatory protein (G protein)-coupled receptors. One of these sequences (R226) exhibited high sequence identity (58%) with the two previously cloned adenosine receptors.
Robert A. Johnson, Qun-Yong Zhou, Gary L. Stiles, Chuanyu Li, Olivier Civelli, Mark E. Olah   +5 more
openaire   +3 more sources

Lung Injury Pathways: Adenosine Receptor 2B Signaling Limits Development of Ischemic Bronchiolitis Obliterans Organizing Pneumonia [PDF]

, 2017
Purpose/Aim of the Study: Adenosine signaling was studied in bronchiolitis obliterans organizing pneumonia (BOOP) resulting from unilateral lung ischemia. Materials and Methods: Ischemia was achieved by either left main pulmonary artery or complete hilar
Auchampach, John, Audi, Said H., Densmore, John C., Dwinell, Melinda R., Geurts, Aron M., Jacobs, Elizabeth R., Jeziorczak, Paul M., Medhora, Meetha, Nayak, Shraddha, Schaid, Terry R.   +9 more
core   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

FSCPX, a Chemical Widely Used as an Irreversible A1 Adenosine Receptor Antagonist, Modifies the Effect of NBTI, a Nucleoside Transport Inhibitor, by Reducing the Interstitial Adenosine Level in the Guinea Pig Atrium

Molecules, 2018
Based on in silico results, recently we have assumed that FSCPX, an irreversible A1 adenosine receptor antagonist, inhibits the action of NBTI that is apparent on E/c curves of adenosine receptor agonists.
Tamas Erdei, Adrienn Monika Szabo, Nora Lampe, Katalin Szabo, Rita Kiss, Judit Zsuga, Csaba Papp, Akos Pinter, Andras Jozsef Szentmiklosi, Zoltan Szilvassy, Bela Juhasz, Rudolf Gesztelyi   +11 more
doaj   +1 more source

A1 adenosine receptor-induced phosphorylation and modulation of transglutaminase 2 activity in H9c2 cells: a role in cell survival [PDF]

, 2016
The regulation of tissue transglutaminase (TG2) activity by the GPCR family is poorly understood. In this study, we investigated the modulation of TG2 activity by the A1 adenosine receptor in cardiomyocyte-like H9c2 cells.H9c2 cells were lysed following ...
Akar, Alan J. Hargreaves, Almami, Basheer, Bennett, Bian, Bollag, Brust, Caccamo, Calmettes, Clare Coveney, Csósz, Dai, David J. Boocock, Davies, Davies, Di-Capua, Dickenson, Dickenson, Dickenson, Dickenson, Dudley, Ethier, Falguni S. Vyas, Filiano, Fretwell, Freund, Germack, Germack, Germack, Germack, Goldsmith, Gundemir, Gundlfinger, Halestrap, Henry, Hescheler, Hoffert, Huang, Imami, John M. Dickenson, Keinan, Kettenbach, Kimes, Lambert, Lee, Lilley, Lorand, Lundby, Matilla, Mhaouty-Kodja, Min, Mishra, Mishra, Mosmann, Nurminskaya, Palacios-Moreno, Perry, Philip L.R. Bonner, Piacentini, Rikova, Robinson, Sabourin, Schaertl, Seshacharyulu, Sheth, Singh, Slaughter, Smith, Stamnaes, Trigwell, Walther, Wang, White, Xu, Yang, Yu, Zhang   +77 more
core   +1 more source

CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability

Molecular Oncology, EarlyView.
Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Aglaia Skolariki, Rose L. Jady‐Clark, Eileen E. Parkes   +2 more
wiley   +1 more source