Results 51 to 60 of about 17,484 (250)

Therapeutic Targeting of ATP7B in Ovarian Carcinoma. [PDF]

, 2009
PURPOSE: Resistance to platinum chemotherapy remains a significant problem in ovarian carcinoma. Here, we examined the biological mechanisms and therapeutic potential of targeting a critical platinum resistance gene, ATP7B, using both in vitro and in ...
Armaiz-Pena, Guillermo N, Coleman, Robert L, Danes, Christopher G, Halder, Jyotsna B, Jennings, Nicholas B, Lee, Jeong-Won, Leshane, Erik S, Lin, Yvonne G, Lopez-Berestein, Gabriel, Lutsenko, Svetlana, Mangala, Lingegowda S, Nick, Alpa M, Schmandt, Rosemarie, Shahzad, Mian M K, Siddik, Zahid H, Sood, Anil K, Spannuth, Whitney A, Tanaka, Takemi, Vivas-Mejia, Pablo E, Wolf, Judith K, Zuzel, Vesna   +20 more
core   +1 more source

Coming to Terms: The Mechanisms of Overplus and Luxury Phosphorus Uptake for Polyphosphate Storage in Microalgae and Yeast

Biotechnology and Bioengineering, EarlyView.
Plouviez et al. give a perspective on the terminology used for describing the mechanisms of polyphosphate accumulation in microalgae and yeast. Their differentiation of mechanisms is based on environmental P availability, polyP chemistry, genetics, or cellular function as described in recent literature.
Maxence Plouviez, Philipp Demling, Alexander Deitert, Jana Fees, Makarius Baier, Tobias Karmainski, Lars M. Blank, Benoit Guieysse   +7 more
wiley   +1 more source

Reinforcement Learning for Robust Dynamic Metabolic Control

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Dynamic metabolic control allows key metabolic fluxes to be modulated in real time, enhancing bioprocess flexibility and expanding available optimization degrees of freedom. This is achieved, for example, via targeted modulation of metabolic enzyme expression.
Sebastián Espinel‐Ríos, River Walser, Dongda Zhang   +2 more
wiley   +1 more source

Plasma membrane Ca2+-ATPases can shape the pattern of Ca2+ transients induced by store-operated Ca2+ entry [PDF]

, 2015
Calcium (Ca2+) is a critical cofactor and signaling mediator in cells, and the concentration of cytosolic Ca2+ is regulated by multiple proteins, including the plasma membrane Ca2+-ATPases (adenosine triphosphatases) (PMCAs), which use ATP to transport ...
Bajzer, Ž., Caride, A.J., Enyedi, Ágnes, Offord, C.P., Padányi, Rita, Pászty, K.   +5 more
core   +1 more source

Adenosine Triphosphatase Activity of Tritrichomonas foetus [PDF]

Journal of General Microbiology, 1979
Homogenates of Tritrichomonas foetus exhibited a Mg2+-dependent adenosine triphosphatase (ATPase) activity, with a pH optimum in Tris buffers of 8.2 to 8.3. The activity was not sensitive to oxygen. At high concentrations, quercetin and 4-chloro-7-nitrobenzofurazan inhibited ATPase activity in the cytoplasmic extract by 20 and 70%, respectively ...
Donald G. Lindmark, Miklós Müller, David Lloyd   +2 more
openaire   +3 more sources

Mechanism and role of regulated cell death in tumor immunity and immunotherapy

Cancer Communications, EarlyView.
Abstract Cancer immune checkpoint inhibitors (ICIs) have brought breakthroughs, but only about one‐third of cancer patients benefit from ICIs. In recent years, targeting non‐apoptotic regulated cell death (RCD) subtypes, such as ferroptosis, necroptosis, autophagy, cuproptosis, and pyroptosis, has emerged as a novel strategy in cancer therapy due to ...
Jingwen Hu, Yan Li, Bingjie Lian, Yitao Mao, Luqing Zhao   +4 more
wiley   +1 more source

Influence of Histamine on Adenosine Triphosphatase

Experimental Biology and Medicine, 1948
In all snake venoms hitherto investigated a powerful ATP-ase (ophio-ATP-ase) has been found, which is activated by magnesium, calcium and cobalt ions and inhibited by zinc ions.1,2 Histamine and pyridoxamine act as inhibitors, epinephrine as activator.The question arose as to whether similar reactions take place in the animal tissues and thus ...
openaire   +3 more sources

Adenosine Triphosphatase Activity of the Vascular System.

Experimental Biology and Medicine, 1952
SummaryThe AT Pase activity of the vascular system of the dog has been studied, lit has been shown that the enzyme content of -the different arteries enjoys wide variation. The venous system does not contain the enzyme. ATPase activity of the aorta of the rat was not influenced by age or captivity.
Carr Cj, John C. Krantz, Frederick K. Bell   +2 more
openaire   +3 more sources

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

Food Frontiers, EarlyView.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Antonio Barberis, Ylenia Spissu, Redouane Lemoui, William N. Setzer, Javad Sharifi‐Rad, Gianfranco Pintus   +8 more
wiley   +1 more source

Mitochondrial dynamics in autoimmune diseases

Rheumatology &Autoimmunity, EarlyView.
Roles of mitochondrial dynamic imbalance in autoimmune diseases. The imbalance of mitochondrial fusion and fission is involved in the occurrence and development of autoimmune diseases, including systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, multiple sclerosis, myasthenia gravis, type 1 diabetes, psoriasis, and autoimmune ...
Ruicong Ma, Cheng Zhang, Jiaqing Liu, Jinyi Ren, Xia Li, Ying Zhao   +5 more
wiley   +1 more source