Results 61 to 70 of about 187,970 (266)

Adenosine Triphosphatase Activity of Tritrichomonas foetus [PDF]

Journal of General Microbiology, 1979
Homogenates of Tritrichomonas foetus exhibited a Mg2+-dependent adenosine triphosphatase (ATPase) activity, with a pH optimum in Tris buffers of 8.2 to 8.3. The activity was not sensitive to oxygen. At high concentrations, quercetin and 4-chloro-7-nitrobenzofurazan inhibited ATPase activity in the cytoplasmic extract by 20 and 70%, respectively ...
Donald G. Lindmark, Miklós Müller, David Lloyd   +2 more
openaire   +3 more sources

A Phase 1, Double‐Blind, Placebo‐Controlled Trial of Sevasemten (EDG‐5506), a Selective Modulator of Fast Skeletal Muscle Contraction, in Healthy Volunteers and Adults With Becker Muscular Dystrophy

Muscle &Nerve, Volume 72, Issue 3, Page 399-407, September 2025.
ABSTRACT Introduction/Aims Sevasemten (EDG‐5506) is an orally administered, investigational small molecule that selectively modulates fast muscle fiber contraction by inhibiting fast myosin ATPase. This study assessed the safety, tolerability, and pharmacokinetics (PK)/pharmacodynamics (PD) of sevasemten in healthy adult volunteers (HVs) and adults ...
Joanne Donovan, Jeffrey A. Silverman, Ben Barthel, Michael DuVall, Molly Madden, James MacDougall, Nicole Rempel Kilburn, Abby Bronson, Marc Evanchik, Gilad Gordon, Kevin Koch, Alan J Russell   +11 more
wiley   +1 more source

Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM [PDF]

, 2019
The human R2TP complex (RUVBL1-RUVBL2-RPAP3-PIH1D1) is an HSP90 co-chaperone required for the maturation of several essential multiprotein complexes, including RNA polymerase II, small nucleolar ribonucleoproteins, and PIKK complexes such as mTORC1 and ...
Fernandez-Leiro, Rafael, Llorca, Oscar, Muñoz-Hernández, Hugo, Pal, Mohinder, Pearl, Laurence H, Prodromou, Chrisostomos, Rodríguez, Carlos F   +6 more
core   +3 more sources

Influence of Histamine on Adenosine Triphosphatase

Experimental Biology and Medicine, 1948
In all snake venoms hitherto investigated a powerful ATP-ase (ophio-ATP-ase) has been found, which is activated by magnesium, calcium and cobalt ions and inhibited by zinc ions.1,2 Histamine and pyridoxamine act as inhibitors, epinephrine as activator.The question arose as to whether similar reactions take place in the animal tissues and thus ...
openaire   +3 more sources

An Unusual Case of Cutaneous Langerhans Cell Sarcoma Lacking S100 Expression: A Case Report and Review of the Literature

Journal of Cutaneous Pathology, Volume 52, Issue 9, Page 554-567, September 2025.
ABSTRACT Langerhans cell sarcoma (LCS) is a rare neoplastic proliferation of Langerhans cell with aggressive clinical behavior and involves multiple organ systems, including the skin. LCS is characterized by marked cytologic atypia, frequent mitoses including atypical ones, and expression of CD1a, S100, and langerin (CD207).
Randa Obid, Austin R. Green, Sion W. Jasmine, Rachel P. Kowal, Brooj Abro, Laura M. Warmke, Magdalena B. Czader, Ahmed K. Alomari, Carina A. Dehner   +8 more
wiley   +1 more source

The Life of a Kidney Podocyte

Acta Physiologica, Volume 241, Issue 8, August 2025.
ABSTRACT Aim Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective
Desiree Loreth, Wiebke Sachs, Catherine Meyer‐Schwesinger   +2 more
wiley   +1 more source

Therapeutic Targeting of ATP7B in Ovarian Carcinoma. [PDF]

, 2009
PURPOSE: Resistance to platinum chemotherapy remains a significant problem in ovarian carcinoma. Here, we examined the biological mechanisms and therapeutic potential of targeting a critical platinum resistance gene, ATP7B, using both in vitro and in ...
Armaiz-Pena, Guillermo N, Coleman, Robert L, Danes, Christopher G, Halder, Jyotsna B, Jennings, Nicholas B, Lee, Jeong-Won, Leshane, Erik S, Lin, Yvonne G, Lopez-Berestein, Gabriel, Lutsenko, Svetlana, Mangala, Lingegowda S, Nick, Alpa M, Schmandt, Rosemarie, Shahzad, Mian M K, Siddik, Zahid H, Sood, Anil K, Spannuth, Whitney A, Tanaka, Takemi, Vivas-Mejia, Pablo E, Wolf, Judith K, Zuzel, Vesna   +20 more
core   +1 more source

Interactions of a photo-affinity ATP analog with cation-stimulated adenosine triphosphatases of human red cell membranes.

Proceedings of the National Academy of Sciences of the United States of America, 1974
To identify and isolate ATP binding and hydrolyzing sites of human red cell membranes we have synthesized a photo-activated ATP analog, 8-azido adenosine triphosphate (N(3)ATP). In the absence of ultraviolet light it is a substrate for both the Mg-ATPase
B. Haley, J. Hoffman
semanticscholar   +1 more source

Plant‐derived vesicle‐like nanoparticles in food crops: emerging insights into nutritional biofortification and biomedical applications

Plant Biotechnology Journal, Volume 23, Issue 8, Page 3260-3282, August 2025.
Summary Food crops, as the cornerstone of human nutrition, not only provide essential macronutrients but also encompass a rich spectrum of bioactive compounds that promote health. Of particular significance are underutilized minor crops, which contain unique beneficial components with proven nutraceutical properties. These valuable bioactive components
Jie Wang, Zhaosheng Kong
wiley   +1 more source

Adenyl cyclases and cAMP in plant signaling - past and present [PDF]

, 2010
In lower eukaryotes and animals 3'-5'-cyclic adenosine monophosphate (cAMP) and adenyl cyclases (ACs), enzymes that catalyse the formation of cAMP from ATP, have long been established as key components and second messengers in many signaling pathways. In
A Moutinho, AR Ashton, B Kaplan, BJ DeYoung, C Balague, Chris Gehring, DB Goodman, DD Leipe, DW Ehrhardt, F Kurosaki, F Kurosaki, F Lemtiri-Chlieh, FJ Maathuis, G Gerisch, GA Robison, H Ehsan, H Sentenac, IN Talke, JA Anderson, K Yoshioka, L Donaldson, L Heginbotham, L Kwezi, LA McCue, LM Iyer, LY Jan, M Morse, N Amrhein, N Ludidi, N Suzuki, O Leyser, Q Leng, Q Leng, R Ali, RP Newton, RW Butcher, S Meier, S Meier, S Mohanty, SM Assmann, T Hoshi, VC Carricarte, VM Wiegant, W Li, W Stuhmer, Y Liu   +45 more
core   +2 more sources