Results 11 to 20 of about 3,470 (173)

STIP1 drives Metabolic Reprogramming in Esophageal Squamous Cell Carcinoma via AHCY‐LDHA Axis

Exploration
Glucose metabolism reprogramming has emerged as a hallmark of cancer. We have reported that high temperature food or drink (>65°C) is the key etiological factors contributing to esophageal squamous cell carcinoma (ESCC) progression.
Guoguo Jin, Yanming Song, Mingyang Yan, Shaobo Fang, Yang Shao, Kexin Zhao, Meng Liu, Qinxin Guo, Xinyang Jia, Chengjuan Zhang, Zhenwei Wang, Kangdong Liu, Xiang Li, Simin Zhao, Mee‐Hyun Lee, Zhiping Guo, Zigang Dong   +16 more
doaj   +2 more sources

Proteomic Investigation of Human Dental Pulp to Identify Individuals Who Are Pregnant. [PDF]

Proteomics Clin Appl
ABSTRACT Biomolecules preserved in dental pulp are increasingly being used to identify individuals in the context of forensics and archaeology. Despite the vast amount of research into host and pathogen DNA, the potential use of physiologically informative proteins preserved in dental pulp has rarely been studied.
Tsutaya T, Fujimoto K, Nakai Y, Mori N, Iguchi R, Moroi A, Yoshizawa K, Ueki K, Kimura Y, Adachi N.   +9 more
europepmc   +2 more sources

Excess S-adenosylmethionine inhibits methylation via catabolism to adenine

Communications Biology, 2022
S-adenosylmethionine (SAM) is a widely available dietary supplement. Exogenous SAM is catabolized to adenine, an inhibitor of adenosylhomocysteinase, leading to widespread methylation inhibition and disruption of circadian rhythms in vitro and in mice.
Kazuki Fukumoto, Kakeru Ito, Benjamin Saer, George Taylor, Shiqi Ye, Mayu Yamano, Yuki Toriba, Andrew Hayes, Hitoshi Okamura, Jean-Michel Fustin   +9 more
doaj   +1 more source

The long non-coding RNA lncMYOZ2 mediates an AHCY/MYOZ2 axis to promote adipogenic differentiation in porcine preadipocytes

BMC Genomics, 2022
Long non-coding RNAs (lncRNAs) play a vital role in regulating adipogenesis. However, the associated regulatory mechanisms have yet to be described in detail in pig.
Yang Yang, Yiqi Wu, Mengting Ji, Xiaoyin Rong, Yanwei Zhang, Shuai Yang, Chang Lu, Chunbo Cai, Pengfei Gao, Xiaohong Guo, Bugao Li, Guoqing Cao   +11 more
doaj   +1 more source

Prognostic Value of Serum Exosomal AHCY Expression in Hepatitis B-Induced Liver Cirrhosis

Frontiers in Medicine, 2021
Objective: We aimed to investigate serum exosomal adenosylhomocysteinase (AHCY) expression in hepatitis B-induced liver cirrhosis (HBV-LC) patients and to determine the prognostic value of serum exosomal AHCY.Methods: We collected serum samples from 100 ...
Ling Tong, Cuilin Yan, Minjie Wang, Jiajia Yang, Hongmei Wang, Ying Wang   +5 more
doaj   +1 more source

Zika virus remodelled ER membranes contain proviral factors involved in redox and methylation pathways

Nature Communications, 2023
Zika virus (ZIKV) has emerged as a global health issue, yet neither antiviral therapy nor a vaccine are available. ZIKV is an enveloped RNA virus, replicating in the cytoplasm in close association with ER membranes.
Solène Denolly, Alexey Stukalov, Uladzimir Barayeu, Alina N. Rosinski, Paraskevi Kritsiligkou, Sebastian Joecks, Tobias P. Dick, Andreas Pichlmair, Ralf Bartenschlager   +8 more
doaj   +1 more source

RyR2/IRBIT regulates insulin gene transcript, insulin content, and secretion in the insulinoma cell line INS-1

Scientific Reports, 2022
The role of ER Ca2+ release via ryanodine receptors (RyR) in pancreatic β-cell function is not well defined. Deletion of RyR2 from the rat insulinoma INS-1 (RyR2KO) enhanced IP3 receptor activity stimulated by 7.5 mM glucose, coincident with reduced ...
Kyle E. Harvey, Emily K. LaVigne, Mohd Saleem Dar, Amy E. Salyer, Evan P. S. Pratt, Paxton A. Sample, Uma K. Aryal, Humaira Gowher, Gregory H. Hockerman   +8 more
doaj   +1 more source

Nosustrophine: An Epinutraceutical Bioproduct with Effects on DNA Methylation, Histone Acetylation and Sirtuin Expression in Alzheimer’s Disease

Pharmaceutics, 2022
Alzheimer’s disease (AD), the most common cause of dementia, causes irreversible memory loss and cognitive deficits. Current AD drugs do not significantly improve cognitive function or cure the disease.
Olaia Martínez-Iglesias, Vinogran Naidoo, Iván Carrera, Lola Corzo, Ramón Cacabelos   +4 more
doaj   +1 more source

ITRAQ Proteomic Analysis of Yellow and Black Skin in Jinbian Carp (Cyprinus carpio)

Life, 2020
Colors are important phenotypic traits for fitness under natural conditions in vertebrates. Previous studies have reported several functional genes and genetic variations of pigmentation, but the formation mechanisms of various skin coloration remained ...
Xiangchen Ye, Lingling Zhou, Jingyi Jia, Lingjing Wei, Yanhong Wen, Xueyu Yan, Jie Huang, Baojiang Gan, Kang Liu, Yejian Lv, Guangfu Hu   +10 more
doaj   +1 more source

In Ovo injection of betaine affects hepatic cholesterol metabolism through epigenetic gene regulation in newly hatched chicks. [PDF]

PLoS ONE, 2015
Betaine is reported to regulate hepatic cholesterol metabolism in mammals. Chicken eggs contain considerable amount of betaine, yet it remains unknown whether and how betaine in the egg affects hepatic cholesterol metabolism in chicks.
Yun Hu, Qinwei Sun, Xiaoliang Li, Min Wang, Demin Cai, Xi Li, Ruqian Zhao   +6 more
doaj   +1 more source