Results 51 to 60 of about 3,470 (173)

Study of mechanism of interaction of truncated isoniazid–nicotinamide adenine dinucleotide adduct against multiple enzymes of Mycobacterium tuberculosis by a computational approach

International Journal of Mycobacteriology, 2015
Objective/Background: Isoniazid (INH) is one of the effective antituberculosis (TB) drugs used for TB treatment. However, most of the drug-resistant Mycobacterium tuberculosis (MTB) clinical strains are resistant to INH, a first-line antituberculous drug.
Lingaraja Jena, Shraddha Deshmukh, Pranita Waghmare, Satish Kumar, Bhaskar C Harinath   +4 more
doaj   +1 more source

Dopaminergic modulation of the hippocampal neuropil proteome identified by bioorthogonal noncanonical amino acid tagging (BONCAT) [PDF]

, 2012
Local protein synthesis and its activity-dependent modulation via dopamine receptor stimulation play an important role in synaptic plasticity – allowing synapses to respond dynamically to changes in their activity patterns. We describe here the metabolic
Dieterich, Daniela C., Hess, Sonja, Hodas, Jennifer J. L., Höche, Nicole, Nehring, Anne, Pielot, Rainer, Schuman, Erin M., Sweredoski, Michael J., Tirrell, David A.   +8 more
core   +1 more source

Comparative Embryology and Transcriptomics of Asellus infernus, an Isopod Crustacean From Sulfidic Groundwater

Evolution &Development, Volume 27, Issue 3, September 2025.
Individuals of Asellus infernus, a sulfidic subterranean population of the Asellus aquaticus species complex from southeastern Romania (left) and surface individuals of A. aquaticus (right). Extreme differences in phenotype are seen comparing the subterranean and surface individuals as adults (top panels) and as embryonic samples (bottom panels ...
Haeli J. Lomheim, Lizet Reyes Rodas, Devon Price, Serban M. Sarbu, Raluca I. Băncilă, Cody Carroll, Layla Freeborn, Sheri Sanders, Meredith E. Protas   +8 more
wiley   +1 more source

Transcriptomic and proteomic analyses of Desulfovibrio vulgaris biofilms: carbon and energy flow contribute to the distinct biofilm growth state. [PDF]

, 2012
BackgroundDesulfovibrio vulgaris Hildenborough is a sulfate-reducing bacterium (SRB) that is intensively studied in the context of metal corrosion and heavy-metal bioremediation, and SRB populations are commonly observed in pipe and subsurface ...
Arkin, Adam P, Clark, Melinda E, Fields, Matthew W, He, Zhili, Joachimiak, Marcin P, Keasling, Jay D, Mukhopadhyay, Aindrila, Redding, Alyssa M, Zhou, Jizhong Z   +8 more
core   +3 more sources

Psidium Defenses Against Meloidogyne enterolobii: Proteomic and Microscopic Analysis of this Plant‐Predator Association

PROTEOMICS, Volume 25, Issue 16, Page 17-27, August 2025.
ABSTRACT Guava (Psidium guajava), referred to as the “tropical apple,” is esteemed for its sweet flavor, nutritional density, and medicinal attributes, being rich in ascorbic acid, phenolics, carotenoids, fibers, and minerals. Despite its agricultural significance, guava cultivation faces considerable challenges from plant‐parasitic nematodes ...
Sara Nállia de Oliveira Costa, Roberta Pena da Paschoa, Camilla Ribeiro Alexandrino, Pamela Maciel Cremonez, Juliana Martins Ribeiro, José Mauro da Cunha e Castro, Maura Da Cunha, Vanildo Silveira, Antônia Elenir Amâncio Oliveira, Kátia Valevski Sales Fernandes   +9 more
wiley   +1 more source

Additional sex combs interacts with enhancer of zeste and trithorax and modulates levels of trimethylation on histone H3K4 and H3K27 during transcription of hsp70. [PDF]

, 2017
BACKGROUND: Maintenance of cell fate determination requires the Polycomb group for repression; the trithorax group for gene activation; and the enhancer of trithorax and Polycomb (ETP) group for both repression and activation.
Brock, Hugh W, Hodgson, Jacob W, Li, Taosui, Mazo, Alexander, Petruk, Svetlana   +4 more
core   +2 more sources

The Landscape of Cancer Metabolism as a Therapeutic Target

Pathology International, Volume 75, Issue 8, Page 387-402, August 2025.
ABSTRACT Cancer cells reprogram their metabolism during progression to adapt to the tumor microenvironment, which is characterized by distinct differences in nutrient availability, oxygen concentrations, and acidity. This metabolic reprogramming can simultaneously create metabolic vulnerabilities unique to cancer cells, making cancer metabolism a ...
Kenji Ohshima
wiley   +1 more source

Proteome analysis of Norway maple (Acer platanoides L.) seeds dormancy breaking and germination: influence of abscisic and gibberellic acids

BMC Plant Biology, 2009
Background Seed dormancy is controlled by the physiological or structural properties of a seed and the external conditions. It is induced as part of the genetic program of seed development and maturation. Seeds with deep physiological embryo dormancy can
Pawłowski Tomasz A
doaj   +1 more source

Characteristic, Regulation and Targeting Strategies of Cancer Stem Cells and Their Niche in Digestive System Tumors

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Cancer stem cells, characterized by self‐renewal, differentiation, heterogeneity, plasticity and tumorigenicity, are regulated by intrinsic factors such as signaling pathways, transcription factors, metabolism and noncoding RNAs, as well as environmental cells (including tumor cells, immune cells and stromal cells), environmental factors and distant ...
Zhenzhen Chen, Huanle Qi, Yapeng Xue, Yaqi Zhang, Zhuo Zhang, Shun Xu, Shixin Liao, Xiaoyu Zeng, Jiayi Wu, Xinrui Lv, Qiankun He, Pingping Zhu   +11 more
wiley   +1 more source

MTHFD1 controls DNA methylation in Arabidopsis. [PDF]

, 2016
DNA methylation is an epigenetic mechanism that has important functions in transcriptional silencing and is associated with repressive histone methylation (H3K9me).
Bischof, Sylvain, Cokus, Shawn J, Díaz de la Garza, Rocío I, Feng, Suhua, Garcia-Salinas, Carolina, Groth, Martin, Hale, Christopher J, Hell, Ruediger, Jacobsen, Steven E, John, Amala, Long, Jeff A, Moissiard, Guillaume, Ramos-Parra, Perla A, Smith, Danielle C, Wang, Haifeng, Wirtz, Markus, Zhai, Jixian   +16 more
core   +2 more sources