Results 31 to 40 of about 70,698 (266)
Methods and clinical development of adenovirus-vectored vaccines against mucosal pathogens
Molecular Therapy: Methods & Clinical Development, 2016 Adenoviruses represent the most widely used viral-vectored platform for vaccine design, showing a great potential in the fight against intracellular infectious diseases to which either there is a lack of effective vaccines or the traditional vaccination ...
Sam Afkhami, Yushi Yao, Zhou Xing
doaj +1 more source
, 2005 Adenoviral vectors have been commonly used in gene therapy protocols, however the success of their use is often limited by the induction of host immunity to the vector.
Kalle, Wouter H.J. +4 more
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Understanding the performance of HIV-1 viral vector vaccines: adenovirus and poxvirus case studies
Frontiers in ImmunologyDespite decades of research, HIV-1 continues to infect millions annually, underscoring the urgent need for a safe and effective vaccine to curb the ongoing global pandemic.
Mahdiyeh M. Manafi +12 more
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The Oncologist, 2002 AbstractLearning ObjectivesAfter completing this course, the reader should be able to:Understand the advantages and disadvantages of recombinant adenoviral vectors for gene delivery.Review the current biological strategies employed in clinical trials utilizing adenoviral mediated gene therapy for cancer.Understand modifications that may improve the ...
Stephan A, Vorburger, Kelly K, Hunt
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Transfer of TALEN sequences into adenoviral vectors and validation of TALEN function.
, 2013 A. The left and right TALEN sequences described in Figure 1 were transferred into an adenoviral destination vector, pAd/PL-DEST, by Gateway® LR recombination. B-D, Example of transduction of Ddx3x TALEN adenoviruses into mouse Neuro-2A cells.
Xin Huang (11077) +4 more
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VaccinesAdenoviral vectors based on the human adenovirus species C serotype 5 (HAdV-C5) are commonly used for vector-based gene therapies and vaccines. In the preclinical stages of development, their safety and efficacy are often validated in suitable animal ...
Jochen M. Wettengel +10 more
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Efficient Gene Transfer and Expression in Islets by an Adenoviral Vector that Lacks All Viral Genes
Cell Transplantation, 1999 Although adenoviral vector-mediated gene transfer has significant potential for gene therapy, host immune responses to virally expressed proteins and small insert capacity may limit its clinical application.
Zhiguang Guo +7 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Adenovirus-associated acute conjunctivitis in Beijing, China, 2011–2013
BMC Infectious Diseases, 2018 Background Human adenovirus (HAdV)-associated acute conjunctivitis is a common infectious disease and causes significant morbidity among residents in Beijing, China.
Jie Li +10 more
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Preclinical Gene Therapy Studies for Hemophilia Using Adenoviral Vectors [PDF]
, 2004 Hemophilia A and B are hereditary coagulation defects resulting from a deficiency of factor VIII (FVIII) and factor IX (FIX), respectively. Introducing a functional FVIII or FIX gene could potentially provide a cure for these bleeding disorders ...
Collen, Desire +7 more
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