Results 21 to 30 of about 35,783 (166)

The Oncogenicity of Human Adenoviruses in Hamsters

Experimental Biology and Medicine, 1968
In 1962 we reported that human adenovirus type 12 induces undifferentiated sarcomas at the site of injection into newborn hamsters in high incidence and after a very short latent period (1,2). Extensive attempts to recover virus from such tumors have been negative in this and several other laboratories (3,4), although Connor et al.
J J, Trentin, G L, Van Hoosier, L, Samper   +2 more
openaire   +2 more sources

Chimpanzee Adenovirus Antibodies in Humans, Sub-Saharan Africa

Emerging Infectious Diseases, 2006
Human sera from the United States, Thailand, and sub-Saharan Africa and chimpanzee sera were tested for neutralizing antibodies to 3 chimpanzee adenoviruses.
Zhiquan Xiang, Yan Li, Ann Cun, Wei Yang, Susan Ellenberg, William M. Switzer, Marcia L. Kalish, Hildegund C.J. Ertl   +7 more
doaj   +1 more source

Characteristics of Noncultivable Adenoviruses Associated with Diarrhea in Infants: A New Subgroup of Human Adenoviruses [PDF]

Journal of Clinical Microbiology, 1979
Virus particles morphologically resembling adenovirus were found in fecal specimens from infants and were examined for cultivability with standard cell culture techniques and for characteristics of human adenoviruses. Specimens from 13 of 15 infants could not be cultivated in cell cultures.
G W, Gary, J C, Hierholzer, R E, Black
openaire   +2 more sources

Elimination of MYCN-Amplified Neuroblastoma Cells by Telomerase-Targeted Oncolytic Virus via MYCN Suppression

Molecular Therapy: Oncolytics, 2020
Neuroblastoma (NB) is a primary malignant tumor of the peripheral sympathetic nervous system. High-risk NB is characterized by MYCN amplification and human telomerase reverse transcriptase (hTERT) rearrangement, contributing to hTERT activation and a ...
Terutaka Tanimoto, Hiroshi Tazawa, Takeshi Ieda, Hiroshi Nouso, Morimichi Tani, Takanori Oyama, Yasuo Urata, Shunsuke Kagawa, Takuo Noda, Toshiyoshi Fujiwara   +9 more
doaj   +1 more source

Humoral immune response to adenovirus induce tolerogenic bystander dendritic cells that promote generation of regulatory T cells. [PDF]

PLoS Pathogens, 2018
Following repeated encounters with adenoviruses most of us develop robust humoral and cellular immune responses that are thought to act together to combat ongoing and subsequent infections.
Thi Thu Phuong Tran, Karsten Eichholz, Patrizia Amelio, Crystal Moyer, Glen R Nemerow, Matthieu Perreau, Franck J D Mennechet, Eric J Kremer   +7 more
doaj   +1 more source

Pyrogenicity of human adenoviruses

Journal of General Virology, 2000
High doses (>1·56×107 p.f.u.) of purified preparations of human adenovirus types 3, 5 and 8 exhibited definite pyrogenic activity when injected intravenously into rabbits. Complete pyrogenic tolerance was obtained not only with homologous types but also with heterologous types of adenovirus.
openaire   +2 more sources

Expression of human CD46 and trans-complementation by murine adenovirus 1 fails to allow productive infection by a group B oncolytic adenovirus in murine cancer cells

Journal for ImmunoTherapy of Cancer, 2018
Background Oncolytic viruses are currently experiencing accelerated development in several laboratories worldwide, with some forty-seven clinical trials currently recruiting.
Janet Lei, Egon J. Jacobus, William K. Taverner, Kerry D. Fisher, Silvio Hemmi, Katy West, Lorna Slater, Fred Lilley, Alice Brown, Brian Champion, Margaret R. Duffy, Len W. Seymour   +11 more
doaj   +1 more source

Downmodulation of El A Protein Expression as a Novel Strategy to Design Cancer-Selective Adenoviruses

Neoplasia: An International Journal for Oncology Research, 2005
Oncolytic adenoviruses are being tested as potential therapies for human malignant tumors, including gliomas. Here we report for the first time that a mutation in the E1A gene results in low levels of ElA protein, conditioning the replication of mutant ...
Hong Jiang, Ramon Alemany, Candelaria Gomez-Manzano, Diana R. Medrano, Michael G. Lemoine, Melissa V. Olson, Marta M. Alonso, Ok-Hee Lee, Charles C. Conrad, W.K. Alfred Yung, Juan Fueyo   +10 more
doaj   +1 more source

Serotype Chimeric Human Adenoviruses for Cancer GeneTherapy

Viruses, 2010
Cancer gene therapy consists of numerous approaches where the common denominator is utilization of vectors for achieving therapeutic effect. A particularly potent embodiment of the approach is virotherapy, in which the replication potential of an ...
Akseli Hemminki, Tuuli Ranki
doaj   +1 more source

The seroprevalence of adenoviruses since 20001

Emerging Microbes and Infections
Human adenoviruses (Ad) are increasingly used as vaccine vectors, especially after Ad5, Ad26, and ChAdY25 (ChAdOx1) were employed as vectors for SARS-CoV-2 vaccines. So far, more than 116 adenovirus genotypes have been identified, divided into 7 species (
Lingling Hong, Jiashun Li, Weikai Zeng, Yuhua Li, Changfa Yu, Shutao Zhao, Ling Chen, Ying Feng   +7 more
doaj   +1 more source