Results 101 to 110 of about 134,365 (335)

Exercise Delays Brain Ageing Through Muscle‐Brain Crosstalk

open access: yesCell Proliferation, EarlyView.
This graphical abstract illustrates the reciprocal crosstalk between the brain and peripheral organs, highlighting the profound impact of exercise on brain health through systemic interactions. It underscores how exercise influences the brain via signals from various organs and, conversely, how the brain modulates functions of peripheral organs.
Shirin Pourteymour   +3 more
wiley   +1 more source

A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains

open access: yesThe FEBS Journal, EarlyView.
Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley   +1 more source

Induction of RAGE shedding by activation of G protein-coupled receptors. [PDF]

open access: yesPLoS ONE, 2012
The multiligand Receptor for Advanced Glycation End products (RAGE) is involved in various pathophysiological processes, including diabetic inflammatory conditions and Alzheimers disease.
Verena V Metz   +3 more
doaj   +1 more source

The onset of labor alters corticotropin-releasing hormone type 1 receptor variant expression in human myometrium : putative role of interleukin-1ß [PDF]

open access: yes, 2007
CRH targets the human myometrium during pregnancy. The efficiency of CRH actions is determined by expression of functional receptors (CRH-R), which are dynamically regulated.
Grammatopoulos, Dimitris   +6 more
core   +1 more source

Allosteric modulation of protein kinase A in individuals affected by NLPD‐PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed

open access: yesThe FEBS Journal, EarlyView.
In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman   +13 more
wiley   +1 more source

The Enigmatic Canal-Associated Neurons Regulate Caenorhabditis elegans Larval Development Through a cAMP Signaling Pathway. [PDF]

open access: yes, 2019
Caenorhabditis elegans larval development requires the function of the two Canal-Associated Neurons (CANs): killing the CANs by laser microsurgery or disrupting their development by mutating the gene ceh-10 results in early larval arrest. How these cells
Chien, Jason   +5 more
core  

Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII [PDF]

open access: yes, 2008
Regulation of intracellular cyclic adenosine 3’, 5’-monophosphate (cAMP) by multiple pathways enables differential function of this ubiquitous second messenger in a context dependent manner.
Collins, Julie   +4 more
core   +2 more sources

Light Modulation of Cellular cAMP by a Small Bacterial Photoactivated Adenylyl Cyclase, bPAC, of the Soil Bacterium Beggiatoa*♦

open access: yesJournal of Biological Chemistry, 2010
The recent success of channelrhodopsin in optogenetics has also caused increasing interest in enzymes that are directly activated by light. We have identified in the genome of the bacterium Beggiatoa a DNA sequence encoding an adenylyl cyclase directly ...
Manuela Stierl   +12 more
semanticscholar   +1 more source

Expression of adenylyl cyclase isoforms in neutrophils

open access: yesBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2003
In the present study, we have identified the expression of adenylyl cyclase (AC) isoforms in rat neutrophils according to the mRNA analysis and the distinct mode of regulation of isoform activity. Agarose gel electrophoresis of reverse transcription-polymerase chain reaction (RT-PCR)-amplified products resulted in a single band of the expected size for
Ling-Chu Chang   +3 more
openaire   +3 more sources

Lipid regulation of adenylyl cyclase Rv1625c from Mycobacterium tuberculosis by its membrane‐domain receptor

open access: yesThe FEBS Journal, EarlyView.
The adenylyl cyclase (AC) Rv1625c from M. tuberculosis is a monomeric progenitor of the nine pseudoheterodimeric mammalian AC isoforms. The hexahelical membrane anchor of Rv1625c serves as an inhibitory receptor for fatty acids, particularly oleic acid. One ligand binds into each monomer of the active Rv1625c dimer.
Anita Charlotte Friderun Schultz   +3 more
wiley   +1 more source

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