Results 101 to 110 of about 102,595 (300)

Innate and learned odor-guided behaviors utilize distinct molecular signaling pathways in a shared dopaminergic circuit

Cell Reports, 2023
Summary: Odor-based learning and innate odor-driven behavior have been hypothesized to require separate neuronal circuitry. Contrary to this notion, innate behavior and olfactory learning were recently shown to share circuitry that includes the ...
Nathaniel C. Noyes, Ronald L. Davis
doaj  

Adult Type 3 Adenylyl Cyclase–Deficient Mice Are Obese

PLoS ONE, 2009
Background A recent study of obesity in Swedish men found that polymorphisms in the type 3 adenylyl cyclase (AC3) are associated with obesity, suggesting the interesting possibility that AC3 may play a role in weight control.
Zhenshan Wang, V. Li, G. Chan, Trongha Phan, Aaron S. Nudelman, Z. Xia, D. Storm   +6 more
semanticscholar   +1 more source

G protein‐coupled receptor‐mediated autophagy in health and disease

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan, Zeynep Aslıhan Durer, Beki Kan   +2 more
wiley   +1 more source

pH sensing via bicarbonate-regulated ‘soluble’ adenylyl cyclase (sAC)

Frontiers in Physiology, 2013
Soluble adenylyl cyclase (sAC) is a source of the second messenger cyclic adenosine 3',5' monophosphate (cAMP). sAC is directly regulated by bicarbonate (HCO3-) ions. In living cells, HCO3- ions are in nearly instantaneous equilibrium with carbon
Nawreen eRahman, Jochen eBuck, Lonny Ray Levin   +2 more
doaj   +1 more source

Differential G protein activation by the long and short isoforms of the dopamine D2 receptor

British Journal of Pharmacology, EarlyView.
Background and Purpose The dopamine D2 receptor is expressed as a short (D2S) and a long (D2L) isoform with 29 additional amino acids in the third intracellular loop. The D2S isoform shows higher presynaptic expression than the D2L isoform, and decreased D2S expression has recently been linked to an increased risk for schizophrenia.
David Reiner‐Link, Jakob Sture Madsen, David E. Gloriam, Hans Bräuner‐Osborne, Alexander S. Hauser   +4 more
wiley   +1 more source

Allosterism in the adenosine A2A and cannabinoid CB2 heteromer

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Allosterism is a regulatory mechanism for GPCRs that can be attained by ligand‐binding or protein–protein interactions with another GPCR. We have studied the influence of the dimer interface on the allosteric properties of the A2A receptor and CB2 receptor heteromer.
Claudia Llinas del Torrent, Iu Raïch, Angel Gonzalez, Jaume Lillo, Nil Casajuana‐Martin, Rafael Franco, Leonardo Pardo, Gemma Navarro   +7 more
wiley   +1 more source

An Adenylyl Cyclase-mAKAPβ Signaling Complex Regulates cAMP Levels in Cardiac Myocytes*

Journal of Biological Chemistry, 2009
Protein kinase A-anchoring proteins (AKAPs) play important roles in the compartmentation of cAMP signaling, anchoring protein kinase A (PKA) to specific cellular organelles and serving as scaffolds that assemble localized signaling cascades.
M. Kapiloff, L. Piggott, Rachna Sadana, Jinliang Li, Lorena Heredia, E. Henson, R. Efendiev, C. Dessauer   +7 more
semanticscholar   +1 more source

Progress on the development of Class A GPCR‐biased ligands

British Journal of Pharmacology, EarlyView.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales, Magdalena M. Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K. Hansen, Nadine Jagerovic, Jan Jakubík, György M. Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo‐Abreu, Gemma Navarro, Rubén Prieto‐Díaz, Mette M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M. Wingler   +20 more
wiley   +1 more source

Soluble Adenylyl Cyclase Controls Mitochondria-dependent Apoptosis in Coronary Endothelial Cells*

Journal of Biological Chemistry, 2009
The cAMP signaling pathway plays an essential role in modulating the apoptotic response to various stress stimuli. Until now, it was attributed exclusively to the activity of the G-protein-responsive transmembrane adenylyl cyclase.
Sanjeev Kumar, S. Kostin, J. Flacke, H. Reusch, Y. Ladilov   +4 more
semanticscholar   +1 more source

Structure, mechanism, and regulation of soluble adenylyl cyclases — similarities and differences to transmembrane adenylyl cyclases

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014
The second messenger cyclic adenosine 3',5'-monophosphate (cAMP) regulates a wide range of physiological processes in almost all organisms. cAMP synthesis is catalyzed by adenylyl cyclases (ACs). All ten mammalian AC isoenzymes (AC1-10) belong to AC Class III, which is defined by sequence homologies in the catalytic domains. Nevertheless, the mammalian
openaire   +3 more sources