Results 111 to 120 of about 68,807 (284)
pH sensing via bicarbonate-regulated ‘soluble’ adenylyl cyclase (sAC)
Frontiers in Physiology, 2013 Soluble adenylyl cyclase (sAC) is a source of the second messenger cyclic adenosine 3',5' monophosphate (cAMP). sAC is directly regulated by bicarbonate (HCO3-) ions. In living cells, HCO3- ions are in nearly instantaneous equilibrium with carbon
Nawreen eRahman +2 more
doaj +1 more source
PACAP induces FSHβ gene expression via EPAC. [PDF]
, 2019 Gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), are heterodimers of a common α subunit and unique β subunits. Regulation of their levels, primarily by GnRH, is critical for reproductive function.
Coss, Djurdjica, Yeh, Debra M
core
Use of a cAMP BRET Sensor to Characterize a Novel Regulation of cAMP by the Sphingosine 1-Phosphate/G13 Pathway [PDF]
, 2007 Regulation of intracellular cyclic adenosine 3',5'-monophosphate (cAMP) is integral in mediating cell growth, cell differentiation, and immune responses in hematopoietic cells. To facilitate studies of cAMP regulation we developed a BRET (bioluminescence
Collins, Julie +11 more
core +2 more sources
Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase
Nature Communications, 2018 It is unclear whether GPCRs, G proteins and adenylyl cyclase (AC) associate through random collisions or defined pre-coupling mechanisms. Using a peptide-based approach, the authors show that heteromers of adenosine A2A and dopamine D2 receptors form pre-
Gemma Navarro +11 more
doaj +1 more source
A Study on the Origin of Peroxisomes: Possibility of Actinobacteria Symbiosis [PDF]
, 2008 The origin of peroxisomes as having developed from the endoplasmic reticulum (ER) was proposed on the basis of the similarity between some peroxisomal proteins and ER proteins, and the localization of some peroxisomal proteins on the ER.
Duhita Narendra +5 more
core +2 more sources
Functional Non‐Nucleoside Adenylyl Cyclase Inhibitors
Chemical Biology & Drug Design, 2014 In this study, we describe the synthesis of novel functional non‐nucleoside adenylyl cyclase inhibitors, which can be easily modified with thiol containing biomolecules such as tumour targeting structures. The linkage between inhibitor and biomolecule contains cleavable bonds to enable efficient intracellular delivery in the reductive milieu of the ...
Lelle, M. +7 more
openaire +4 more sources
Annals of the New York Academy of Sciences, EarlyView.Krisanaklan reduces CFTR‐dependent intestinal chloride and fluid secretion by inhibiting the Na+,K+‐ATPase and K+ channels in epithelial cells. Consequently, this natural, plant‐derived product may limit secretory diarrhea caused by a diverse array of microbial pathogens. However, by dissipating the transmembrane Na+ gradient, Krisanaklan also inhibits
Tessa A. Groeneweg +4 more
wiley +1 more source
Journal of Pharmacological Sciences, 2005 Ovarian cancer G-protein-coupled receptor 1 (OGR1), previously proposed as a receptor for sphingosylphosphorylcholine (SPC), has recently been identified as a proton-sensing or extracellular pH-responsive G-protein-coupled receptor stimulating inositol ...
Chihiro Mogi +9 more
doaj +1 more source
The organisation and functions of local Ca2+ signals [PDF]
, 2001 Calcium (Ca2+) is a ubiquitous intracellular messenger, controlling a diverse range of cellular processes, such as gene transcription, muscle contraction and cell proliferation.
Berridge, Michael J. +2 more
core
Mutational mapping of RAS-responsive domains of the Saccharomyces cerevisiae adenylyl cyclase [PDF]
, 1990 Large deletion and small insertion mutations in the adenylyl cyclase gene of Saccharomyces cerevisiae were used to map regions required for activation by RAS protein in vitro.
Ballester, R. +5 more
core +2 more sources