Results 121 to 130 of about 102,595 (300)

Exercise Delays Brain Ageing Through Muscle‐Brain Crosstalk

Cell Proliferation, EarlyView.
This graphical abstract illustrates the reciprocal crosstalk between the brain and peripheral organs, highlighting the profound impact of exercise on brain health through systemic interactions. It underscores how exercise influences the brain via signals from various organs and, conversely, how the brain modulates functions of peripheral organs.
Shirin Pourteymour, Rakesh Kumar Majhi, Frode A. Norheim, Christian A. Drevon   +3 more
wiley   +1 more source

Intestinal brush border membranes contain regulatory subunits of adenylyl cyclase. [PDF]

, 1987
Pedro Domı́nguez, Gloria Velasco, Francisco Barros, Pedro S. Lazo   +3 more
openalex   +1 more source

A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains

The FEBS Journal, EarlyView.
Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley   +1 more source

Cellular localization of the Mn²⁺‐dependent adenylyl cyclase (AC) in rat testis [PDF]

, 1981
Jan O. Gordeladze, K. Purvis, O. P. F. Clausen, F. F. G. Rommerts, V. Hansson   +4 more
openalex   +1 more source

A PDE4 shortform degrader: a first in isoform‐specific PDE4 inhibition

The FEBS Journal, EarlyView.
Clinically used phosphodiesterase 4 (PDE4) inhibitors lack selectivity for PDE4 enzyme isoforms, which leads to documented side effects. Building in enzyme selectivity has proved difficult because all PDE4 enzymes share highly conserved catalytic domains. The report by Sin et al.
Donald H. Maurice
wiley   +1 more source

PGE₁ and hCG Responsive Adenylyl Cyclases in Interstitial Cells from Rat Testis: Biphasic Effects of Calcium [PDF]

, 1980
Jan O. Gordeladze, Tore Jahnsen, Ken Purvis, Vidar Hansson   +3 more
openalex   +1 more source

Allosteric modulation of protein kinase A in individuals affected by NLPD‐PKA, a neurodegenerative disease in which the PRKAR1B L50R variant is expressed

The FEBS Journal, EarlyView.
In healthy neurons, Protein kinase A (PKA) forms a tetrameric holoenzyme enabling precise allosteric regulation. We characterized a novel neurodegenerative disease, neuronal loss, and parkinsonism driven by PRKAR1B mutation (NLPD‐PKA), demonstrating disrupted holoenzyme assembly, reduced cooperativity, and increased catalytic subunit nuclear ...
Tal Benjamin‐Zukerman, Valeria Pane, Rania Safadi‐Safa, Meir Solomon, Varda Lev‐Ram, Mohammad Aboraya, Anwar Dakwar, Daniela Bertinetti, Andrew Hoy, Merel O. Mol, John van Swieten, Rodrigo Maillard, Friedrich W. Herberg, Ronit Ilouz   +13 more
wiley   +1 more source

Effect of Estradiol Withdrawal on Luteal Hormone-Responsive Adenylyl Cyclase and Luteal Function in the Pseudopregnant Rabbit1 [PDF]

, 1980
Sharon L. Day, Joel Abramowitz, HOWARD J. KIRCHICK, Lutz Birnbaumer   +3 more
openalex   +1 more source

Hypotheses in light detection by vertebrate ancient opsin in the bird brain

Journal of Neuroendocrinology, EarlyView.
Abstract Extra‐retinal photoreception is common across fish and avian species. In birds, the hypothalamus contains non‐visual photoreceptors that detect light and regulate multiple endocrine systems. To date, light‐dependent control of seasonal reproduction is one of the most well‐studied systems that require deep brain photoreception.
Tyler J. Stevenson, Timothy A. Liddle, Simone L. Meddle, Jonathan H. Pérez, Stuart N. Peirson, Russell G. Foster, Gaurav Majumdar   +6 more
wiley   +1 more source

Cholera Toxin Action on Rabbit Corpus Luteum Membranes: Effects on Adenylyl Cyclase Activity and Adenosine Diphospho-ribosylation of the Stimulatory Guanine Nucleotide-binding Regulatory Component1 [PDF]

, 1985
Anne N. Hirshfield
openalex   +1 more source