Results 141 to 150 of about 68,807 (284)
Advances in Therapeutic Antibody Discovery and Development Targeting G Protein‐Coupled Receptors
Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.ABSTRACT G protein‐coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody‐based therapies. This review offers an overview of the therapeutic GPCR‐antibody target landscape and examines the diversity ...
Catherine J. Hutchings +6 more
wiley +1 more source
Biochemical and Physiological Effects of Galanin in Health and Disease
The FASEB Journal, Volume 40, Issue 2, 31 January 2026.Galanin is a biologically active neuropeptide hormone that mediates its effects through three galanin receptors. Galanin signaling induces changes in glucose homeostasis amongst others and plays a dynamic role in the physiological health of many organ systems.
Patrick Mireles +3 more
wiley +1 more source
Short-Term Plasticity of Cyclic Adenosine 3′,5′-Monophosphate Signaling in Anterior Pituitary Corticotrope Cells: The Role of Adenylyl Cyclase Isotypes [PDF]
, 2003 F. Antoni +4 more
openalex +1 more source
Advanced Healthcare Materials, Volume 15, Issue 4, 26 January 2026.Recent advances in diagnostics have accelerated the development of miniaturized wearable technologies for the continuous monitoring of diseases. This paradigm is shifting healthcare away from invasive, centralized blood tests toward decentralized monitoring, using alternative body biofluids.
Lanka Tata Rao +2 more
wiley +1 more source
Advanced Science, Volume 13, Issue 2, 9 January 2026.Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu +5 more
wiley +1 more source
Hormone Stimulation of Type III Adenylyl Cyclase Induces Ca2+ Oscillations in HEK-293 Cells [PDF]
, 1995 Gary A. Wayman +2 more
openalex +1 more source
Advanced Science, Volume 13, Issue 1, 5 January 2026.Working model of Adss1‐mediated regulation of energy metabolism in adipose tissue. In beige adipocytes, Adss1 interacts with HDAC3 in the cytoplasm, and its loss reduces nuclear HDAC3 while increasing cytosolic fractions. This redistribution suppresses HDAC activity and enhances H3K27 acetylation at the Gk promoter, leading to transcriptional ...
Jingjing Sun +16 more
wiley +1 more source
Regulation of hormone-sensitive calcium influx by the adenylyl cyclase system in renal epithelial cells. [PDF]
, 1994 Kenichiro Kitamura, R. Tyler Miller
openalex +1 more source
Advanced Science, Volume 13, Issue 5, 27 January 2026.A proposed mechanism to explain the role of CYP4X1/sEH‐14,15‐EET‐EA system in colon cancer immune escape. 14,15‐EET‐EA, 14,15‐epoxyeicosatrienoic acid‐ethanolamide; sEH, soluble epoxide hydrolase; CYP4X1, cytochrome P450 4X1; GPR119, G‐protein coupled receptor 119; EGFR, epidermal growth factor receptor; Gs, Gαs subunit; cAMP, cyclic adenosine ...
Min Mo +10 more
wiley +1 more source
Activated Gsα but not Giα prevents the thermal inactivation of adenylyl cyclase in plasma membranes derived from S49 lymphoma cells [PDF]
, 1994 Petr Kvapil +2 more
openalex +1 more source