Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source
Role of adenylyl cyclase in reduced β-adrenoceptor-mediated vasorelaxation during maturation [PDF]
Brazilian Journal of Medical and Biological Research, 2016 Beta-adrenergic receptor (βAR)-dependent blood vessel relaxation is impaired in older animals and G protein activation has been suggested as the causative mechanism.
O.A. López-Canales +5 more
doaj +3 more sources
Role of membrane microdomains in compartmentation of cAMP signaling. [PDF]
PLoS ONE, 2014 Spatially restricting cAMP production to discrete subcellular locations permits selective regulation of specific functional responses. But exactly where and how cAMP signaling is confined is not fully understood.
Shailesh R Agarwal +7 more
doaj +1 more source
Colocalization of protein kinase A with adenylyl cyclase enhances protein kinase A activity during induction of long-lasting long-term-potentiation. [PDF]
PLoS Computational Biology, 2011 The ability of neurons to differentially respond to specific temporal and spatial input patterns underlies information storage in neural circuits. One means of achieving spatial specificity is to restrict signaling molecules to particular subcellular ...
Myungsook Kim +8 more
doaj +1 more source
G protein-regulated endocytic trafficking of adenylyl cyclase type 9
eLife, 2020 GPCRs are increasingly recognized to initiate signaling via heterotrimeric G proteins as they move through the endocytic network, but little is known about how relevant G protein effectors are localized.
André M Lazar +7 more
doaj +1 more source
PTH1R Actions on Bone Using the cAMP/Protein Kinase A Pathway
Frontiers in Endocrinology, 2022 After the initial signaling action of parathyroid hormone (PTH) on bone was shown to be activation of adenylyl cyclase, its target was found to be cells of the osteoblast lineage, to the exclusion of osteoclasts and their precursors. This led to the view
T. John Martin
doaj +1 more source
Overexpression of the type 1 adenylyl cyclase in the forebrain leads to deficits of behavioral inhibition [PDF]
, 2015 The type 1 adenylyl cyclase (AC1) is an activity-dependent, calcium-stimulated adenylyl cyclase expressed in the nervous system that is implicated in memory formation. We examined the locomotor activity, and impulsive and social behaviors of AC1+ mice, a
Cao, Hong +4 more
core +2 more sources
Molecular, Enzymatic, and Cellular Characterization of Soluble Adenylyl Cyclase From Aquatic Animals. [PDF]
, 2018 The enzyme soluble adenylyl cyclase (sAC) is the most recently identified source of the messenger molecule cyclic adenosine monophosphate. sAC is evolutionarily conserved from cyanobacteria to human, is directly stimulated by [Formula: see text] ions ...
Acin-Perez +58 more
core +2 more sources
Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors
Cellular Physiology and Biochemistry, 2018 Background/Aims: Signaling of Gs protein-coupled receptors (GsPCRs) is accomplished by stimulation of adenylyl cyclase, causing an increase of the intracellular cAMP concentration, activation of the intracellular cAMP effectors protein kinase A (PKA) and
Thomas Pleli +11 more
doaj +1 more source
Disruption of type 3 adenylyl cyclase expression in the hypothalamus leads to obesity [PDF]
, 2016 Evidence from human studies and transgenic mice lacking the type 3 adenylyl cyclase (AC3) indicates that AC3 plays a role in the regulation of body weight. It is unknown in which brain region AC3 exerts such an effect.
Cao, Hong +3 more
core +2 more sources