Results 11 to 20 of about 134,365 (335)
Adenylyl Cyclase in Ocular Health and Disease: A Comprehensive Review [PDF]
BiologyAdenylyl cyclases (ACs) are a group of enzymes that convert adenosine-5′-triphosphate (ATP) to cyclic adenosine 3′,5′ monophosphate (cAMP), a vital and ubiquitous signalling molecule in cellular responses to hormones and neurotransmitters. There are nine
Polly Thompson +5 more
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Structural basis of adenylyl cyclase 9 activation [PDF]
Nature Communications, 2022 Adenylyl cyclases (ACs) generate the second messenger cAMP and play an important role in cellular signaling. Here, the authors use cryo-EM to trace the conformational changes resulting from binding to partial and full activators to one of these enzymes ...
Chao Qi +12 more
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Editorial: Adenylyl cyclase isoforms as potential drug targets [PDF]
Frontiers in Pharmacology, 2022 Tarsis F. Brust +3 more
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Physiological Roles of Mammalian Transmembrane Adenylyl Cyclase Isoforms.
Physiological Reviews, 2021 Adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1-9, that serve as major effector enzymes of G protein-coupled receptors.
K. Ostrom +6 more
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Role of soluble adenylyl cyclase in mitochondria.
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014 The soluble adenylyl cyclase (sAC) catalyzes the conversion of ATP into cyclic AMP (cAMP). Recent studies have shed new light on the role of sAC localized in mitochondria and its product cAMP, which drives mitochondrial protein phosphorylation and regulation of the oxidative phosphorylation system and other metabolic enzymes, presumably through the ...
F. Valsecchi, Csaba Konrad, G. Manfredi
semanticscholar +4 more sources
Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
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The small molecule triclabendazole decreases the intracellular level of cyclic AMP and increases resistance to stress in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2013 The Ras-adenylyl cyclase-protein kinase A nutrient-sensing pathway controls metabolism, proliferation and resistance to stress in Saccharomyces cerevisiae. The genetic disruption of this pathway increases resistance to a variety of stresses. We show here
Yong Joo Lee, Runhua Shi, Stephan N Witt
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The YHS-Domain of an Adenylyl Cyclase from Mycobacterium phlei Is a Probable Copper-Sensor Module. [PDF]
PLoS ONE, 2015 YHS-domains are small protein modules which have been proposed to bind transition-metal ions like the related TRASH-domains. They are found in a variety of enzymes including copper-transporting ATPases and adenylyl cyclases.
Jürgen Ulrich Linder
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Role of adenylyl cyclase in reduced β-adrenoceptor-mediated vasorelaxation during maturation [PDF]
Brazilian Journal of Medical and Biological Research, 2016 Beta-adrenergic receptor (βAR)-dependent blood vessel relaxation is impaired in older animals and G protein activation has been suggested as the causative mechanism.
O.A. López-Canales +5 more
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Adenylyl Cyclases in Mycobacteria [PDF]
Journal of Life Science, 2011 Adenylyl cyclase (AC) catalyzes the formation of cyclic AMP (cAMP) from ATP. The cAMP produced by AC serves as a secondary messenger in a variety of signal transduction pathways, and controls various cellular functions in many organisms. ACs can be grouped into six classes based on their primary amino acid sequences. Eukaryotes and mycobacteria contain
Han-Seung Jeon, Jeong-Il Oh, In-Jeong Ko
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