Results 11 to 20 of about 102,595 (300)

Adenylyl Cyclase in Ocular Health and Disease: A Comprehensive Review [PDF]

Biology
Adenylyl cyclases (ACs) are a group of enzymes that convert adenosine-5′-triphosphate (ATP) to cyclic adenosine 3′,5′ monophosphate (cAMP), a vital and ubiquitous signalling molecule in cellular responses to hormones and neurotransmitters. There are nine
Polly Thompson, Virginija Vilkelyte, Malgorzata Woronkowicz, Mitra Tavakoli, Piotr Skopinski, Harry Roberts   +5 more
doaj   +2 more sources

Regulation of Adenylyl Cyclase by Membrane Potential [PDF]

Journal of Biological Chemistry, 1998
Mammalian adenylyl cyclases possess 12 transmembrane-spanning domains and bear a superficial resemblance to certain classes of ion channels. Some evidence suggests that bacterial and sea urchin sperm adenylyl cyclases can be regulated by membrane depolarization. In the present study, we explored the effect of altering membrane potential on the adenylyl
Dermot M.F. Cooper, Michael J. Schell, Peter Thorn, Robin F. Irvine   +3 more
openalex   +6 more sources

Editorial: Adenylyl cyclase isoforms as potential drug targets [PDF]

Frontiers in Pharmacology, 2022
Tarsis F. Brust, Tarsis F. Brust, Rennolds S. Ostrom, Val J. Watts   +3 more
doaj   +2 more sources

Physiological Roles of Mammalian Transmembrane Adenylyl Cyclase Isoforms.

Physiological Reviews, 2021
Adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1-9, that serve as major effector enzymes of G protein-coupled receptors.
K. Ostrom, J. E. Lavigne, Tarsis F. Brust, R. Seifert, C. Dessauer, V. Watts, R. Ostrom   +6 more
semanticscholar   +1 more source

Advances in exosome biomarkers for cervical cancer

Cancer Medicine, Volume 11, Issue 24, Page 4966-4978, December 2022., 2022
Cancer‐derived exosomes may promote CC metastasis by boosting cellular epithelial‐mesenchymal transformation (EMT), controlling the proliferation, invasion, or migration of cancer cells, as well as influencing immune escape and aiding angiogenesis.
Zihan Ran, Shaobo Wu, Zijng Ma, Xiuwen Chen, Jing Liu, Jingcheng Yang   +5 more
wiley   +1 more source

The Chemerin Receptor CMKLR1 Requires Full‐Length Chemerin for High Affinity in Contrast to GPR1 as Demonstrated by a New Nanoluciferase‐Based Binding Assay

ChemMedChem, Volume 17, Issue 23, December 5, 2022., 2022
The adipokine chemerin and the short peptide agonist chemerin‐9 activate two GPCRs: CMKLR1 and GPR1. Here, we established a nanoluciferase based binding assay to analyze differences in ligand binding. For GPR1, both ligands show high affinity and comparable binding.
Anne Sophie Czerniak, Kevin Kretschmer, Tina Weiß, Annette G. Beck‐Sickinger   +3 more
wiley   +1 more source

The small molecule triclabendazole decreases the intracellular level of cyclic AMP and increases resistance to stress in Saccharomyces cerevisiae. [PDF]

PLoS ONE, 2013
The Ras-adenylyl cyclase-protein kinase A nutrient-sensing pathway controls metabolism, proliferation and resistance to stress in Saccharomyces cerevisiae. The genetic disruption of this pathway increases resistance to a variety of stresses. We show here
Yong Joo Lee, Runhua Shi, Stephan N Witt
doaj   +1 more source

Wiring the senses: Factors that regulate peripheral axon pathfinding in sensory systems

Developmental Dynamics, Volume 252, Issue 1, Page 81-103, January 2023., 2023
Abstract Sensory neurons of the head are the ones that transmit the information about the external world to our brain for its processing. Axons from cranial sensory neurons sense different chemoattractant and chemorepulsive molecules during the journey and in the target tissue to establish the precise innervation with brain neurons and/or receptor ...
Gemma Nomdedeu‐Sancho, Berta Alsina
wiley   +1 more source

Defining the Biologically Plausible Taxonomic Domain of Applicability of an Adverse Outcome Pathway: A Case Study Linking Nicotinic Acetylcholine Receptor Activation to Colony Death

Environmental Toxicology and Chemistry, Volume 42, Issue 1, Page 71-87, January 2023., 2023
Abstract For the majority of developed adverse outcome pathways (AOPs), the taxonomic domain of applicability (tDOA) is typically narrowly defined with a single or a handful of species. Defining the tDOA of an AOP is critical for use in regulatory decision‐making, particularly when considering protection of untested species.
Marissa A. Jensen, Donovan J. Blatz, Carlie A. LaLone   +2 more
wiley   +1 more source

The YHS-Domain of an Adenylyl Cyclase from Mycobacterium phlei Is a Probable Copper-Sensor Module. [PDF]

PLoS ONE, 2015
YHS-domains are small protein modules which have been proposed to bind transition-metal ions like the related TRASH-domains. They are found in a variety of enzymes including copper-transporting ATPases and adenylyl cyclases.
Jürgen Ulrich Linder
doaj   +1 more source