Results 141 to 150 of about 19,332 (219)

MdPHYB2‐MdPIF1 Module Regulates Transcription Factors to Mediate Light‐Dependent ALA‐Induced Apple Anthocyanin Biosynthesis

Plant, Cell &Environment, Volume 49, Issue 11, Page 7808-7824, November 2026.
ABSTRACT Light is a primary environmental signal that induces plant anthocyanin accumulation. The plant growth regulator 5‐aminolevulinic acid (ALA) has also been proven to effectively promote anthocyanin accumulation in apple. However, the underlying regulatory mechanisms remain unknown.
Liuzi Zhang, Yuyan An, Jianting Zhang, Liangju Wang   +3 more
wiley   +1 more source

ADCY4 inhibits cAMP-induced growth of breast cancer by inactivating FAK/AKT and ERK signaling but is frequently silenced by DNA methylation

Scientific Reports
Local increases in cyclic adenosine monophosphate (cAMP) caused by specific adenylyl cyclases (ACs) can selectively modulate related proteins. AC-selective drugs have an advantage in side effect control, and the specific AC may finally be considered as a
Guangrui Pan, Mingquan Huang, Shaozhi Fu, Yu Wang, Lijia He, Bin Wu, Jinping Yang, Sheng Lin, Yu Fan   +8 more
doaj   +1 more source

Tuning the Triazolotriazine Scaffold Toward Selective A3 Adenosine Receptor Antagonists: From Molecular Recognition to Neuroprotection

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Structure‐based optimization of the triazolo‐triazine scaffold afforded highly potent and selective adenosine A3 receptor antagonists. Replacement of the classical 2‐furyl group with phenyl‐based substituents markedly improved A3 receptor affinity and selectivity.
Veronika Kost, Filippo Prencipe, Federica Panozzi, Veronica Salmaso, Sonja Kachler, Karl‐Norbert Klotz, Elisabetta Coppi, Simone Adorinni, Stefano Moro, Anna Maria Pugliese, Stephanie Federico, Giampiero Spalluto, Tatiana Da Ros   +12 more
wiley   +1 more source

Inhibition of calcium-stimulated adenylyl cyclase subtype 1 (AC1) for the treatment of pain and anxiety symptoms in Parkinson’s disease mice model

Molecular Pain
Pain and anxiety are two common and undertreated non-motor symptoms in Parkinson’s disease (PD), which affect the life quality of PD patients, and the underlying mechanisms remain unclear.
Zhaoxiang Zhou, Qi-Yu Chen, Min Zhuo, Ping-Yi Xu   +3 more
doaj   +1 more source

Expression of multiple adenylyl cyclase isoforms in human and dog thyroid.

, 2000
Although the TSH receptor and Galpha(s), which activate the cAMP cascade in the thyroid gland have been much studied, nothing is known about the adenylyl cyclase (AC) isoforms which are actually involved in this pathway.
Hanoune, Jacques, Cosson, E, J.-E Dumont, Pirlot, Marc, M Pirlot, J Hanoune, N Defer, J Van Sande, Vanvooren, Vanessa, Dumont, Jacques Emile, A Allgeier, V Vanvooren, Allgeier, Anouk, E Cosson, Van Sande, Jacqueline, Defer, N   +15 more
core   +1 more source

Can intracellular cAMP dynamics enable scalable computation?

Frontiers in Cellular Neuroscience, 2015
Ravi eIyengar
doaj   +1 more source

Adenylyl cyclase 6 is selectively regulated by protein kinase A phosphorylation in a region involved in Galphas stimulation

, 1997
Receptors activate adenylyl cyclases through the Galphas subunit. Previous studies from our laboratory have shown in certain cell types that express adenylyl cyclase 6 (AC6), heterologous desensitization included reduction of the capability of adenylyl ...
Smit, M J; id_orcid, Iyengar, R, Li, J, Magnusson, R, Weng, G, Harry, A, Chen, Y, Bai, X, Pieroni, J P   +8 more
core   +1 more source

IP₃-mediated Ca²⁺ release regulates atrial Ca²⁺ transients and pacemaker function by stimulation of adenylyl cyclases.

Am J Physiol Heart Circ Physiol, 2021
Capel RA, Bose SJ, Collins TP, Rajasundaram S, Ayagama T, Zaccolo M, Burton RB, Terrar DA.   +7 more
europepmc   +1 more source

Adenylyl cyclase 9 as a molecular scaffold to dissect the mechanisms of membrane adenylyl cyclases. [PDF]

Protein Sci
Kantarci I, Haoriwa H, Korkhov VM.
europepmc   +1 more source

cAMPing out with the keepers of the gate: Adenylyl cyclases get cozy with Orai. [PDF]

Cell Calcium, 2019
Hofer AM.
europepmc   +1 more source