Results 141 to 150 of about 8,032 (234)
Substrate specificity determinants of class III nucleotidyl cyclases
, 2016 The two second messengers in signalling, cyclic AMP and cyclic GMP, are produced by adenylyl and guanylyl cyclases respectively. Recognition and discrimination of the substrates ATP and GTP by the nucleotidyl cyclases are vital in these reactions ...
Syed, Wajeed +10 more
core +1 more source
Pharmacologic MRI Brain Imaging Studies of Serotonin 5‐HT1 Receptor Agonists in Awake Mice
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.ABSTRACT Serotonin (5‐hydroxytryptamine, 5‐HT) type‐1 G protein‐coupled receptors are expressed throughout the central nervous system. 5‐HT1AR activation is the putative mechanism of approved drugs for generalized anxiety disorder and major depressive disorder and is being studied in the treatment of autism and neurological disorders.
Brittany M. Brems +5 more
wiley +1 more source
Expression of multiple adenylyl cyclase isoforms in human and dog thyroid.
, 2000 Although the TSH receptor and Galpha(s), which activate the cAMP cascade in the thyroid gland have been much studied, nothing is known about the adenylyl cyclase (AC) isoforms which are actually involved in this pathway.
Hanoune, Jacques +15 more
core +1 more source
GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling
British Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
wiley +1 more source
Cyclic AMP In Mycobacteria Adenylyl Cyclases And Cyclic AMP Receptor Proteins [PDF]
, 2010 The discovery of cyclic AMP (cAMP), nearly 50 years ago by Sutherland radically altered the appreciation of metabolic regulation. Since then the presence of cAMP and its tremendous physiological impact has been demonstrated in many prokaryotic systems ...
Sharma, Ritu
core
Tyrphostins are inhibitors of guanylyl and adenylyl cyclases
, 2004 Guanylyl cyclase C (GC-C), the receptor for guanylin, uroguanylin, and the heat-stable enterotoxin, regulates fluid balance in the intestine and extraintestinal tissues.
Shenoy, Avinash R. +2 more
core +1 more source
Journal of Neurochemistry, Volume 170, Issue 6, June 2026.Components and properties of Ca2+ buffers in astrocytes, which should be considered for data interpretation and in computational modeling of astrocyte Ca2+ activity. ABSTRACT Astrocytic Ca2+ signaling is essential for maintaining physiological brain function, including the modulation of synaptic transmission, neurovascular coupling, and ion homeostasis.
Kerstin Lenk +2 more
wiley +1 more source
Roles of Soluble Adenylyl Cyclase in cAMP Synthesis in Animal Cells
, 2022 The second messenger cyclic adenosine 3′,5′-monophosphate (cAMP) synthesis is catalyzed by adenylyl cyclases (ACs). The second messenger cAMP participates in many physiological processes in cells.
Nguyen, Thi Mong Diep
core
Journal of the World Aquaculture Society, Volume 57, Issue 3, June 2026.Abstract Cholecystokinin receptor (CCKR), an important recognition receptor for the gastrointestinal hormone cholecystokinin (CCK) in the endocrine system, plays a crucial role in regulating immune responses in mammals. In this study, a novel cholecystokinin receptor (CiCCKR) was identified from the grass carp Ctenopharyngodon idella.
Ran Peng +14 more
wiley +1 more source
Can intracellular cAMP dynamics enable scalable computation?
Frontiers in Cellular Neuroscience, 2015 Ravi eIyengar
doaj +1 more source