Results 141 to 150 of about 12,139 (230)

Inhibition of calcium-stimulated adenylyl cyclase subtype 1 (AC1) for the treatment of pain and anxiety symptoms in Parkinson’s disease mice model

Molecular Pain
Pain and anxiety are two common and undertreated non-motor symptoms in Parkinson’s disease (PD), which affect the life quality of PD patients, and the underlying mechanisms remain unclear.
Zhaoxiang Zhou, Qi-Yu Chen, Min Zhuo, Ping-Yi Xu   +3 more
doaj   +1 more source

Can intracellular cAMP dynamics enable scalable computation?

Frontiers in Cellular Neuroscience, 2015
Ravi eIyengar
doaj   +1 more source

Soluble adenylyl cyclase

, 2018
\(\bf Aims\) In contrast to the membrane bound adenylyl cyclases, the soluble adenylyl cyclase (sAC) is activated by bicarbonate and divalent ions including calcium. sAC is located in the cytosol, nuclei and mitochondria of several tissues including cardiac muscle. However, its role in cardiac pathology is poorly understood. Here we investigate whether
Schirmer, Ilona, Bualeong, Tippaporn (Dr. rer. nat.), Budde, Heidi (M. Sc.), Cimiotti, Diana (Dr. rer. nat.), Appukuttan, Avinash (Dr. rer. nat.), Klein, Nicole (M. Sc.), Steinwascher, Philip (M.Sc.), Reusch, Hans-Peter (Dr. med.), Mügge, Andreas (Prof. Dr. med.), Meyer, Rainer (Apl. Prof. Dr. rer. nat.), Ladilov, Yuri, Jaquet, Kornelia (Prof. Dr. rer. nat.)   +11 more
openaire   +1 more source

Compartmentalized cAMP Generation by Engineered Photoactivated Adenylyl Cyclases. [PDF]

Cell Chem Biol, 2019
O'Banion CP, Vickerman BM, Haar L, Lawrence DS.   +3 more
europepmc   +1 more source

IP₃-mediated Ca²⁺ release regulates atrial Ca²⁺ transients and pacemaker function by stimulation of adenylyl cyclases.

Am J Physiol Heart Circ Physiol, 2021
Capel RA, Bose SJ, Collins TP, Rajasundaram S, Ayagama T, Zaccolo M, Burton RB, Terrar DA.   +7 more
europepmc   +1 more source

cAMPing out with the keepers of the gate: Adenylyl cyclases get cozy with Orai. [PDF]

Cell Calcium, 2019
Hofer AM.
europepmc   +1 more source

High voltage activated Ca2+ channel [PDF]

, 1993
A Cavalié, A Hui, A Mikami, A Röhrkasten, A Welling, A Welling, AE Lacerda, AM Brown, C Kleuss, C Mundina-Weilenmann, D Singer, E Bosse, E Bosse, E Perez-Reyes, E Perez-Reyes, E Perez-Reyes, E Rios, EI Rotman, F Hofmann, G Varadi, H Nakayama, HL Kim, HR Guy, HS Kim, IM Mintz, J Garcia, J Striessnig, J Striessnig, K Itagaki, K Nunoki, KS Jongh De, KS Jongh De, KS Jongh De, L Hymel, M Bertolino, M Biel, M Biel, M Kameyama, M Pragnell, ME Williams, ME Williams, P Lory, P Ruth, R Hullin, R Staudinger, RI Norman, RJ Diebold, RJ Miller, RS Kass, S Hamilton, S Regulla, S Seino, SB Ellis, SD Jay, SD Jay, SJ Dubel, T Schneider, T Tanabe, T Tanabe, T Tanabe, T Tanabe, TP Snutch, TP Snutch, TVB Starr, U Klöckner, V Flockerzi, W Trautwein, WJ Koch, X Wei, Y Lai, Y Mori   +70 more
core   +1 more source

Adenylyl Cyclases as Therapeutic Targets in Neuroregeneration. [PDF]

Int J Mol Sci
Tomczak J, Kapsa A, Boczek T.
europepmc   +1 more source

A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening. [PDF]

Cell Signal, 2019
Getz RA, Kwak G, Cornell S, Mbugua S, Eberhard J, Huang SX, Abbasi Z, de Medeiros AS, Thomas R, Bukowski B, Dranchak PK, Inglese J, Hoffman CS.   +12 more
europepmc   +1 more source

Biochemical pharmacology of adenylyl cyclases in cancer. [PDF]

Biochem Pharmacol
Chandra Jena B, Flaherty DP, O'Brien VP, Watts VJ.   +3 more
europepmc   +1 more source