Results 151 to 160 of about 8,032 (234)

Monosodium glutamate‐mediated Ca2+‐dependent intestinal epithelial ion transports in health and IBS‐D in male mice

Physiological Reports, Volume 14, Issue 11, June 2026.
Abstract Despite the ubiquitous use of monosodium glutamate (MSG) as a food additive, its specific effects on intestinal health and disease remain largely unclear. Here we found mucosal application of MSG induced an upward intestinal short‐circuit current (Isc) in the murine ileum, which was significantly reduced by extracellular Cl−, Na+, and Ca2 ...
Yunxian Wang, Fenglan Chu, Yanhua Gong, Ruihong Guo, Hui Dong   +4 more
wiley   +1 more source

Stimulation of Mammalian G-protein-responsive Adenylyl Cyclases by Carbon Dioxide

Carbon dioxide is fundamental to the physiology of all organisms. There is considerable interest in the precise molecular mechanisms that organisms use to directly sense CO2.
Fenyk S, Gray MA, Hodgson DRW, Cann MJ, Hess KC, Holliday PM, Townsend PD   +6 more
core  

cAMPing out with the keepers of the gate: Adenylyl cyclases get cozy with Orai. [PDF]

Cell Calcium, 2019
Hofer AM.
europepmc   +1 more source

Particulate guanylyl cyclases: multiple mechanisms of activation.

, 2000
Cyclic GMP (cGMP), a key messenger in several signal transduction pathways, is synthesized from GTP by a family of enzymes termed guanylyl cyclases, which are found in two forms: cytosolic (soluble) and membrane-bound (particulate).
Gorczyca, Wojciech, Kobiałka, Marcin
core  

A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening. [PDF]

Cell Signal, 2019
Getz RA, Kwak G, Cornell S, Mbugua S, Eberhard J, Huang SX, Abbasi Z, de Medeiros AS, Thomas R, Bukowski B, Dranchak PK, Inglese J, Hoffman CS.   +12 more
europepmc   +1 more source

Neuronal LAMP2A-mediated reduction of adenylyl cyclases induces acute neurodegenerative responses and neuroinflammation after ischemic stroke. [PDF]

Cell Death Differ
Shi D, Bai Y, Long R, Xia J, Xu W, Qin D, Yang X, Ding M, Hou XY.   +8 more
europepmc   +1 more source

Correction: Cyanobacteriochrome-based photoswitchable adenylyl cyclases (cPACs) for broad spectrum light regulation of cAMP levels in cells. [PDF]

J Biol Chem, 2018
Blain-Hartung M, Rockwell NC, Moreno MV, Martin SS, Gan F, Bryant DA, Lagarias JC.   +6 more
europepmc   +1 more source

Calcium/calmodulin-stimulated adenylyl cyclases 1 and 8 regulate reward-related brain activity and ethanol consumption. [PDF]

Brain Imaging Behav, 2019
Bosse KE, Ghoddoussi F, Eapen AT, Charlton JL, Susick LL, Desai K, Berkowitz BA, Perrine SA, Conti AC.   +8 more
europepmc   +1 more source

Soluble adenylyl cyclase

, 2018
\(\bf Aims\) In contrast to the membrane bound adenylyl cyclases, the soluble adenylyl cyclase (sAC) is activated by bicarbonate and divalent ions including calcium. sAC is located in the cytosol, nuclei and mitochondria of several tissues including cardiac muscle. However, its role in cardiac pathology is poorly understood. Here we investigate whether
Schirmer, Ilona, Bualeong, Tippaporn (Dr. rer. nat.), Budde, Heidi (M. Sc.), Cimiotti, Diana (Dr. rer. nat.), Appukuttan, Avinash (Dr. rer. nat.), Klein, Nicole (M. Sc.), Steinwascher, Philip (M.Sc.), Reusch, Hans-Peter (Dr. med.), Mügge, Andreas (Prof. Dr. med.), Meyer, Rainer (Apl. Prof. Dr. rer. nat.), Ladilov, Yuri, Jaquet, Kornelia (Prof. Dr. rer. nat.)   +11 more
openaire   +1 more source

Optimization of a 1,3,4-oxadiazole series for inhibition of Ca²⁺/calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain. [PDF]

Eur J Med Chem, 2019
Kaur J, Soto-Velasquez M, Ding Z, Ghanbarpour A, Lill MA, van Rijn RM, Watts VJ, Flaherty DP.   +7 more
europepmc   +1 more source