Results 151 to 160 of about 16,663 (278)

CYP4X1/sEH‐Dependent Endocannabinoid Metabolism Drives Fibroblast‐Mediated Immunosuppression to Limit Immunotherapy in Colon Cancer

Advanced Science, Volume 13, Issue 5, 27 January 2026.
A proposed mechanism to explain the role of CYP4X1/sEH‐14,15‐EET‐EA system in colon cancer immune escape. 14,15‐EET‐EA, 14,15‐epoxyeicosatrienoic acid‐ethanolamide; sEH, soluble epoxide hydrolase; CYP4X1, cytochrome P450 4X1; GPR119, G‐protein coupled receptor 119; EGFR, epidermal growth factor receptor; Gs, Gαs subunit; cAMP, cyclic adenosine ...
Min Mo, Xuewei Chen, Yanzhuo Liu, Chenlong Wang, Xuehan Chen, Nan Zhang, Nan He, Ying Li, Jingyi Wang, Honglei Chen, Jing Yang   +10 more
wiley   +1 more source

The organisation and functions of local Ca²⁺ signals [PDF]

, 2001
Calcium (Ca2+) is a ubiquitous intracellular messenger, controlling a diverse range of cellular processes, such as gene transcription, muscle contraction and cell proliferation.
Berridge, Michael J., Bootman, Martin D., Lipp, Peter   +2 more
core  

Activated G_sα but not G_iα prevents the thermal inactivation of adenylyl cyclase in plasma membranes derived from S49 lymphoma cells [PDF]

, 1994
Petr Kvapil, Jiřı́ Novotný, Lennart A. Ransnäs   +2 more
openalex   +1 more source

Integrated ERK‐PKA‐YAP/TAZ‐SHH Signaling Orchestrates Cortical Radial Glia Identity and Lineage Diversification

Advanced Science, Volume 13, Issue 5, 27 January 2026.
This study shows that ERK/PKA upregulation in mammalian cortical radial glia (RGs) sustains neurogenesis and suppresses gliogenesis. YAP/TAZ activation promotes ependymal cell formation, while enhanced SHH‐SMO signaling induces astrocyte, oligodendrocytes, and olfactory bulb interneuron generation.
Zhuangzhi Zhang, Zhejun Xu, Tongye Fu, Jialin Li, Feihong Yang, Chuannan Yang, Wenhui Zheng, Zizhuo Sha, Yanjing Gao, Mengge Sun, Zhenmeiyu Li, Jing Ding, Xiaosu Li, Zhengang Yang   +13 more
wiley   +1 more source

Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis

, 2009
Yossan‐Var Tan, Catalina Abad, Robert Lopez, Hongmei Dong, Shen Liu, Alice W. Lee, Rosa P. Gomariz, Javier Leceta, James A. Waschek   +8 more
openalex   +1 more source

Ca ²⁺ -Stimulated Adenylyl Cyclase AC1 Generates Efficient Biological Pacing as Single Gene Therapy and in Combination With HCN2 [PDF]

, 2012
Gerard J.J. Boink, Bruce D. Nearing, Iryna N. Shlapakova, Lian Duan, Yelena Kryukova, Yevgeniy Bobkov, Hanno L. Tan, Ira S. Cohen, Peter Danilo, Richard B. Robinson, Richard L. Verrier, Michael R. Rosen   +11 more
openalex   +1 more source

Glutamate Receptors and Synaptic Plasticity in Health and Disease: A Personal Journey

Hippocampus, Volume 36, Issue 1, January 2026.
ABSTRACT I describe my progress in understanding synaptic plasticity in the hippocampus. Over the decades my lab has focused on the roles of glutamate receptors (AMPARs, NMDARs, mGluRs and KARs) and associated signaling molecules in LTP and LTD. Most of our studies have been conducted in area CA1 (Schaffer collateral—commissural pathway) with some ...
Graham L. Collingridge
wiley   +1 more source

Adenylyl cyclase 4 does not regulate collecting duct water and sodium handling [PDF]

, 2014
Wararat Kittikulsuth, Deborah Stuart, Donald E. Kohan   +2 more
openalex   +1 more source

There are more things in heaven and Earth than we dream of in our physiology

The Journal of Physiology, EarlyView.
Victor A. Maltsev, Michael D. Stern, Edward G. Lakatta   +2 more
wiley   +1 more source

From Synaptic Plasticity and Critical Periods to Social Behavior and Stress: Getting to, and Staying in, CA2

Hippocampus, Volume 36, Issue 1, January 2026.
ABSTRACT Hippocampal Area CA2, with some exceptions, had long been neglected in in vivo studies, due largely to its small size, and in in vitro studies because of its general similarity to CA3 and CA1. Increasing evidence showing that CA2 was molecularly distinct led to the increased appreciation of CA2 as a separate region, and as such, that it likely
Serena M. Dudek
wiley   +1 more source