Results 161 to 170 of about 83,442 (296)

Localization of mRNAs Encoding Ca2+-inhibitable Adenylyl Cyclases along the Renal Tubule

open access: yesJournal of Biological Chemistry, 1996
Expression of Ca2+-inhibitable types V and VI adenylyl cyclases was studied by reverse transcription-polymerase chain reaction in rat renal glomeruli and nephron segments isolated by microdissection.
D. Chabardès   +6 more
semanticscholar   +1 more source

Gαq signalling from endosomes: A new conundrum

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 14, Page 3068-3089, July 2025.
Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley   +1 more source

Intestinal brush border membranes contain regulatory subunits of adenylyl cyclase. [PDF]

open access: green, 1987
Pedro Domı́nguez   +3 more
openalex   +1 more source

G protein‐coupled receptor‐mediated autophagy in health and disease

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 14, Page 3151-3162, July 2025.
G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan   +2 more
wiley   +1 more source

Differential G protein activation by the long and short isoforms of the dopamine D2 receptor

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 14, Page 3336-3352, July 2025.
Background and Purpose The dopamine D2 receptor is expressed as a short (D2S) and a long (D2L) isoform with 29 additional amino acids in the third intracellular loop. The D2S isoform shows higher presynaptic expression than the D2L isoform, and decreased D2S expression has recently been linked to an increased risk for schizophrenia.
David Reiner‐Link   +4 more
wiley   +1 more source

Allosterism in the adenosine A2A and cannabinoid CB2 heteromer

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 14, Page 3371-3384, July 2025.
Abstract Background and Purpose Allosterism is a regulatory mechanism for GPCRs that can be attained by ligand‐binding or protein–protein interactions with another GPCR. We have studied the influence of the dimer interface on the allosteric properties of the A2A receptor and CB2 receptor heteromer.
Claudia Llinas del Torrent   +7 more
wiley   +1 more source

Analysis of diverse signal transduction pathways using the genetic model system Caenorhabditis elegans [PDF]

open access: yes, 2003
Signal transduction allows cells to respond to signals from their environment and is therefore important for most biological processes. The binding of an extracellular signalling molecule to a cell-surface receptor is the first step in most signal ...
Moorman, Celine
core  

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