Self-resistance mechanism to acyldepsipeptide antibiotics in the Streptomyces producer [PDF]
mBioClp proteases are ubiquitous in bacteria and play an important role in regulatory proteolysis and in maintaining protein homeostasis within the bacterial cell. They consist of a tetradecameric, proteolytic ClpP core and associated AAA+ Clp-ATPases.
Dhana Thomy +6 more
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Antibiotic Acyldepsipeptides Stimulate the Streptomyces Clp-ATPase/ClpP Complex for Accelerated Proteolysis [PDF]
mBio, 2022 Clp proteases consist of a proteolytic, tetradecameric ClpP core and AAA+ Clp-ATPases. Streptomycetes, producers of a plethora of secondary metabolites, encode up to five different ClpP homologs, and the composition of their unusually complex Clp ...
Laura Reinhardt +7 more
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Kırgızistan’da Manevi ve Kültürel Değerler Eğitimi Olarak “Adep Sabagı”
Dini Araştırmalar, 2021 Bu çalışma Kırgızistan’da milli ve manevi değerleri gelecek nesle aktarma çabası olarak görülen Adep dersinin mahiyetini ortaya koymayı amaçlamaktadır.
Kubatali Topchubaev
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TÜRKİYE’DE AİLE EĞİTİMİ UYGULAMALARI: AİLEDE DİN EĞİTİMİ PROGRAMI (ADEP) ÖRNEĞİ
Diyanet İlmi Dergi, 2022 Değişen aile yapısı, uyarıcıların farklılaşması, ailelerin bütün çevre etkenlerini kuşatmakta zorlanması, destek alabilecekleri kurum ve kuruluşlara ihtiyaç hissetmesi ebeveynlere yönelik eğitimleri gerekli hale getirmektedir. Bu
Gülsüm Pehlivan Ağırakça
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Frontiers in Molecular Biosciences, 2021 Rising antibiotic resistance urgently calls for the discovery and evaluation of novel antibiotic classes and unique antibiotic targets. The caseinolytic protease Clp emerged as an unprecedented target for antibiotic therapy 15 years ago when it was ...
Heike Brötz-Oesterhelt +2 more
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A Conformationally Constrained Cyclic Acyldepsipeptide Is Highly Effective in Mice Infected with Methicillin-Susceptible and -Resistant Staphylococcus aureus. [PDF]
PLoS ONE, 2016 Cyclic acyldepsipeptides (ADEPs) are a novel class of antibacterial agents, some of which (e.g., ADEP 4) are highly active against Gram-positive bacteria.
Marios Arvanitis +7 more
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South African Journal of Chemical Engineering, 2023 Natural zeolite (NZ) from desilication and activation was prepared to support the Ni catalyst. The catalyst was utilized for the hydrodeoxygenation (HDO) of the palm fatty acid distillate (PFAD) into green diesel.
Isalmi Aziz +3 more
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Cell Division Protein FtsZ Is Unfolded for N-Terminal Degradation by Antibiotic-Activated ClpP
mBio, 2020 Antibiotic acyldepsipeptides (ADEPs) deregulate ClpP, the proteolytic core of the bacterial Clp protease, thereby inhibiting its native functions and concomitantly activating it for uncontrolled proteolysis of nonnative substrates.
Nadine Silber +5 more
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Pillaring of bentonite clay with Zr, Ti, and Ti/Zr by ultrasonic technique for biodiesel production
South African Journal of Chemical Engineering, 2023 The current study concentrated on employing metal pillared bentonite catalysts to transform waste cooking oil. The goal of this research was to create pillared bentonite catalyst for effective low temperature conversion. The ultrasonic technique was used
Egi Agustian +3 more
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Progression of the late-stage divisome is unaffected by the depletion of the cytoplasmic FtsZ pool
Communications Biology, 2021 Silber, Mayer, and colleagues examine how the depletion of the cytoplasmic FtsZ pool, triggered by ADEP antibiotics, affects the different stages of divisome formation and progression in Bacillus subtilis.
Nadine Silber +3 more
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