Origin and Evolution of the Multifaceted Adherens Junction Component Plekha7 [PDF]
Frontiers in Cell and Developmental Biology, 2022 Plekha7 is a key adherens junction component involved in numerous functions in mammalian cells. Plekha7 is the most studied member of the PLEKHA protein family, which includes eight members with diverse functions.
Antonis Kourtidis +4 more
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Transcriptome analysis of adherens junction pathway-related genes after peripheral nerve injury [PDF]
Neural Regeneration Research, 2018 The neural regeneration process is driven by a wide range of molecules and pathways. Adherens junctions are critical cellular junctions for the integrity of peripheral nerves.
Sheng Yi, Xing-Hui Wang, Ling-Yan Xing
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Actin-dependent α-catenin oligomerization contributes to adherens junction assembly [PDF]
Nature CommunicationsClassic cadherins, specifically E-cadherin in most epithelial cells, are transmembrane adhesion receptors, whose intracellular region interacts with proteins, termed catenins, forming the cadherin-catenin complex (CCC).
Regina B. Troyanovsky +2 more
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Repeat DNA methylation is modulated by adherens junction signaling [PDF]
Communications BiologyThrough its involvement in gene transcription and heterochromatin formation, DNA methylation regulates how cells interact with their environment. Nevertheless, the extracellular signaling cues that modulate the distribution of this central chromatin ...
Lisa-Marie Brenner +8 more
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Comparative study of in vitro effects of different nanoparticles at non-cytotoxic concentration on the adherens junction of human vascular endothelial cells [PDF]
International Journal of Nanomedicine, 2019 Tao Wen,1,* Aiyun Yang,1,* Lingyu Piao,2 Suisui Hao,1 Lifan Du,1 Jie Meng,1 Jian Liu,1 Haiyan Xu11Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, People’s Republic of ...
Wen T +7 more
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p120ctn and P-cadherin but not E-cadherin regulate cell motility and invasion of DU145 prostate cancer cells. [PDF]
PLoS ONE, 2010 Adherens junctions consist of transmembrane cadherins, which interact intracellularly with p120ctn, beta-catenin and alpha-catenin. p120ctn is known to regulate cell-cell adhesion by increasing cadherin stability, but the effects of other adherens ...
Sandra Kümper, Anne J Ridley
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Effects of acute and chronic disease on cell junctions in mouse liver
EXCLI Journal : Experimental and Clinical Sciences, 2023 Cell junctions, including anchoring, occluding and communicating junctions, play an indispensable role in tissue architecture and homeostasis. Consequently, malfunctioning of cell junctions is linked with a wide range of disorders, including in liver ...
Raf Van Campenhout +2 more
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Role of spectraplakin in Drosophila photoreceptor morphogenesis. [PDF]
PLoS ONE, 2011 BACKGROUND:Crumbs (Crb), a cell polarity gene, has been shown to provide a positional cue for the apical membrane domain and adherens junction during Drosophila photoreceptor morphogenesis.
Uyen Ngoc Mui +2 more
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Scattering of MCF7 cells by heregulin ß-1 depends on the MEK and p38 MAP kinase pathway. [PDF]
PLoS ONE, 2013 Heregulin (HRG) β1 signaling promotes scattering of MCF7 cells by inducing breakdown of adherens and tight junctions. Here, we show that stimulation with HRG-β1 causes the F-actin backbone of junctions to destabilize prior to the loss of adherent ...
Rintaro Okoshi +3 more
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Sorbin and SH3 domain-containing protein 2 (SORBS2) is a component of the acto-myosin ring at the apical junctional complex in epithelial cells. [PDF]
PLoS ONE, 2017 SORBS2 is a scaffolding protein associated with Abl/Arg non-receptor tyrosine kinase pathways and is known to interact with actin and several other cytoskeletal proteins in various cell types.
Karin Fredriksson-Lidman +3 more
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