Results 141 to 150 of about 52,251 (235)
EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier
The FEBS Journal, EarlyView.Cell‐surface CLDN‐5 protein levels can be evaluated using a probe that can bind to the extracellular domains of CLDN‐5. A probe derived from Clostridium perfringens enterotoxin allows us to isolate cells with high CLDN‐5 protein levels from a knockout cell library.
Yosuke Hashimoto +8 more
wiley +1 more source
Adherens junction proteins on the move-From the membrane to the nucleus in intestinal diseases. [PDF]
Front Cell Dev Biol, 2022 Lessey LR +3 more
europepmc +1 more source
Journal of Anatomy, EarlyView.‘Outside‐in’ expression of Fz6 across multiple layers of mouse embryo epidermis is connected to Fz6 asymmetry in the basal layer plane. Fz6 loss‐of‐function correlated with failure to: coordinate axial bias of cell long axis orientation across epidermal layers, switch axial cell long axis orientation during suprabasal layer development and establish ...
C. J. Formstone
wiley +1 more source
Pore-forming activity of S. pneumoniae pneumolysin disrupts the paracellular localization of the epithelial adherens junction protein E-cadherin. [PDF]
Infect Immun, 2023 Xu S +8 more
europepmc +1 more source
Inflammatory and Immunological Basis of Periodontal Diseases
Journal of Periodontal Research, EarlyView.The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima +3 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney +4 more
wiley +1 more source
Adherens Junctions and Cadherins in Drosophila Development
, 2012 Drosophila represents a paradigm for the analysis of the cellular, molecular and genetic mechanisms of development and is an ideal model system to study the contribution of Adherens Junctions (AJs) and their major components, cadherins, to morphogenesis.
Letizia, Annalisa, Llimargas, Marta
openaire +3 more sources
The Journal of Physiology, EarlyView.Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley +1 more source
The complex of Fas-associated factor 1 with Hsp70 stabilizes the adherens junction integrity by suppressing RhoA activation. [PDF]
J Mol Cell Biol, 2022 Song S +9 more
europepmc +1 more source
Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 678-687, March 2026.Vascular leakage and its associated phenomena vasodilation and endothelial activation are pathophysiological features of various diseases. Multiple drug candidates targeting these phenomena are in development, necessitating translational models to demonstrate proof‐of‐pharmacology and proof‐of‐mechanism in early‐phase clinical trials.
Marella Cornelia Elizabeth van Ruissen +10 more
wiley +1 more source