Results 91 to 100 of about 52,241 (196)

Insights into the molecular mechanism of Sjogren's syndrome [PDF]

, 2017
Sjogren’s syndrome (SS) is a chronic autoimmune disease, that affects primarily salivary and lacrimal glands, leading to increased morbidity. Recent studies indicate that loss of salivary gland function is associated with defective cell polarity ...
Langara, Hans A.
core  

Rab7a is required to degrade select blood-brain barrier junctional proteins after ischemic stroke

Acta Neuropathologica Communications
The integrity of adherens and tight junctions is critical for blood-brain barrier (BBB) function in the healthy brain. Disassembly of cell junctions due to degradation of adherens and tight junction-associated proteins leads to acute BBB dysfunction ...
Azzurra Cottarelli, Danny Jamoul, Mary Claire Tuohy, Sanjid Shahriar, Michael Glendinning, Grace Prochilo, Aimee L. Edinger, Ahmet Arac, Dritan Agalliu   +8 more
doaj   +1 more source

The T-type voltage-gated Ca2+ channel CaV3.1 involves in the disruption of respiratory epithelial barrier induced by Pasteurella multocida toxin

Virulence
Pasteurella multocida toxin (PMT) is an exotoxin produced by several members of the zoonotic respiratory pathogen P. multocida. The role of PMT in disrupting the mammalian respiratory barrier remains to be elucidated.
Haixin Bi, Fei Wang, Lin Lin, Dajun Zhang, Menghan Chen, Yuyao Shang, Lin Hua, Huanchun Chen, Bin Wu, Zhong Peng   +9 more
doaj   +1 more source

The polarized expression of Na+,K+-ATPase in epithelia depends on the association between beta-subunits located in neighboring cells [PDF]

, 2005
The polarized distribution of Na+,K+-ATPase plays a paramount physiological role, because either directly or through coupling with co- and countertransporters, it is responsible for the net movement of, for example, glucose, amino acids, Ca2+, K+, Cl ...
Balda, MS, Cereijido, M, Contreras, RG, Lazaro, A, Matter, K, Moreno, J, Roldan, ML, Shoshani, L   +7 more
core  

Contact inhibition of locomotion and mechanical cross-talk between cell-cell and cell-substrate adhesion determines the pattern of junctional tension in epithelial cell aggregates

, 2016
We generated a computational approach to analyze the biomechanics of epithelial cell aggregates, either island or stripes or entire monolayers, that combines both vertex and contact-inhibition-of-locomotion models to include both cell-cell and cell ...
Caldwell, Benjamin J., Coburn, Luke, Gomez, Guillermo A., Lobaskin, Vladimir, Lopez, Hender, Moussa, Elliott, Neufeld, Zoltan, Noppe, Adrian, Priya, Rashmi, Roberts, Anthony P., Yap, Alpha S., Yap, Chloe   +11 more
core   +1 more source

Actin filament association at adherens junctions

The Journal of Medical Investigation, 2017
The adherens junction (AJ) is a cadherin-based and actin filament associated cell-to-cell junction. AJs can contribute to tissue morphogenesis and homeostasis and their association with actin filaments is crucial for the functions. There are three types of AJs in terms of the mode of actin filament/AJ association.
openaire   +3 more sources

PKCα and CPI-17 expression and spatial-temporal distribution with activation in pig stomach antrum and fundus [PDF]

, 2010
Smooth muscle contraction is a complicated process coordinated by contractile, regulatory and cytoskeletal proteins. The force generation depends on the phosphorylation of Myosin Regulatory Light Chain (MLC20). Myosin Light Chain Kinase (MLCK) and Myosin
Zhang, Yu
core   +1 more source

Distinct ligand binding sites in integrin alpha3beta1 regulate matrix adhesion and cell-cell contact. [PDF]

, 2003
The integrin alpha3beta1 mediates cellular adhesion to the matrix ligand laminin-5. A second integrin ligand, the urokinase receptor (uPAR), associates with alpha3beta1 via a surface loop within the alpha3 beta-propeller (residues 242-246) but outside ...
Chapman, Harold A, Ching, Tsui-Ting, Kreidberg, Jordan A, Kugler, Matthias C, Tom, Clifford C, Wei, Ying, Zhang, Feng   +6 more
core  

Adherens Junctions and Cadherins in Drosophila Development

, 2012
Drosophila represents a paradigm for the analysis of the cellular, molecular and genetic mechanisms of development and is an ideal model system to study the contribution of Adherens Junctions (AJs) and their major components, cadherins, to morphogenesis.
Letizia, Annalisa, Llimargas, Marta
openaire   +3 more sources

The components of an electrical synapse as revealed by expansion microscopy of a single synaptic contact

eLife
Most nervous systems combine both transmitter-mediated and direct cell–cell communication, known as ‘chemical’ and ‘electrical’ synapses, respectively. Chemical synapses can be identified by their multiple structural components.
Sandra P Cárdenas-García, Sundas Ijaz, Alberto E Pereda   +2 more
doaj   +1 more source